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Literature DB >> 21717030

Kinetic discrimination in recognition of DNA quadruplex targets by guanine-rich heteroquadruplex-forming PNA probes.

Subhadeep Roy¹, Kimberly J Zanotti, Connor T Murphy, Farial A Tanious, W David Wilson, Danith H Ly, Bruce A Armitage.

Abstract

Guanine-rich peptide nucleic acid probes hybridize to DNA G quadruplex targets with high affinity, forming PNA-DNA heteroquadruplexes. We report a surprising degree of kinetic discrimination for PNA heteroquadruplex formation with a series of DNA targets. The fastest hybridization is observed for targets folded into parallel morphologies. This journal is © The Royal Society of Chemistry 2011

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Year: 2011 PMID： 21717030 PMCID： PMC3163151 DOI： 10.1039/c1cc12805a

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

20 in total

1. Hybridization of PNA to structured DNA targets: quadruplex invasion and the overhang effect.

Authors: B Datta; B A Armitage
Journal: J Am Chem Soc Date: 2001-10-03 Impact factor: 15.419

2. Formation of a PNA2-DNA2 hybrid quadruplex.

Authors: Bhaskar Datta; Christoph Schmitt; Bruce A Armitage
Journal: J Am Chem Soc Date: 2003-04-09 Impact factor: 15.419

3. Engineering the quadruplex fold: nucleoside conformation determines both folding topology and molecularity in guanine quadruplexes.

Authors: Chung-Fei Tang; Richard H Shafer
Journal: J Am Chem Soc Date: 2006-05-03 Impact factor: 15.419

4. Solution structure of the biologically relevant G-quadruplex element in the human c-MYC promoter. Implications for G-quadruplex stabilization.

Authors: Attila Ambrus; Ding Chen; Jixun Dai; Roger A Jones; Danzhou Yang
Journal: Biochemistry Date: 2005-02-15 Impact factor: 3.162

5. RNA guanine quadruplex invasion by complementary and homologous PNA probes.

Authors: Violeta L Marin; Bruce A Armitage
Journal: J Am Chem Soc Date: 2005-06-08 Impact factor: 15.419

6. An intramolecular G-quadruplex structure with mixed parallel/antiparallel G-strands formed in the human BCL-2 promoter region in solution.

Authors: Jixun Dai; Thomas S Dexheimer; Ding Chen; Megan Carver; Attila Ambrus; Roger A Jones; Danzhou Yang
Journal: J Am Chem Soc Date: 2006-02-01 Impact factor: 15.419

7. Hybridization of complementary and homologous peptide nucleic acid oligomers to a guanine quadruplex-forming RNA.

Authors: Violeta L Marin; Bruce A Armitage
Journal: Biochemistry Date: 2006-02-14 Impact factor: 3.162

8. Propeller-type parallel-stranded G-quadruplexes in the human c-myc promoter.

Authors: Anh Tuân Phan; Yasha S Modi; Dinshaw J Patel
Journal: J Am Chem Soc Date: 2004-07-21 Impact factor: 15.419

9. Loop and backbone modifications of peptide nucleic acid improve g-quadruplex binding selectivity.

Authors: Sabrina Lusvarghi; Connor T Murphy; Subhadeep Roy; Farial A Tanious; Iulia Sacui; W David Wilson; Danith H Ly; Bruce A Armitage
Journal: J Am Chem Soc Date: 2009-12-30 Impact factor: 15.419

10. Human telomeric sequence forms a hybrid-type intramolecular G-quadruplex structure with mixed parallel/antiparallel strands in potassium solution.

Authors: Attila Ambrus; Ding Chen; Jixun Dai; Tiffanie Bialis; Roger A Jones; Danzhou Yang
Journal: Nucleic Acids Res Date: 2006-05-19 Impact factor: 16.971

4 in total