| Literature DB >> 21712145 |
Afsheen Arshad1, Hasnah Osman, Mark C Bagley, Chan Kit Lam, Suriyati Mohamad, Anis Safirah Mohd Zahariluddin.
Abstract
Two novel series of hydrazinyl thiazolyl coumarin derivatives have been synthesized and fully characterized by IR, (1)H NMR, (13)C NMR, elemental analysis and mass spectral data. The structures of some compounds were further confirmed by X-ray crystallography. All of these derivatives, 10a-d and 15a-h, were screened in vitro for antimicrobial activity against various bacteria species including Mycobacterium tuberculosis and Candida albicans. The compounds 10c, 10d and 15e exhibited very good activities against all of the tested microbial strains.Entities:
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Year: 2011 PMID： 21712145 DOI： 10.1016/j.ejmech.2011.05.044
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514