Xue Bian1, Hui Chen, Lianming Liao. 1. Department of Head and Neck Surgery, Military General Hospital of Beijing, Dongshiliutiao Road, Beijing, China. yexiaodan100@yahoo.cn
Abstract
BACKGROUND: Nasopharyngeal carcinoma is sensitive to radiotherapy. When there is local relapse, re-irradiation treatment is inevitably associated with serious complications and decreased quality of life. Surgical resection offers an alternative treatment option with acceptable morbidity. METHODS: Seventy-one consecutive patients with primary recurrence of nasopharyngeal carcinoma after radiation underwent nasopharyngectomy from January 1, 1990 to June 30, 2006. Follow-up ranged from 12 to 127 months. RESULTS: The actuarial 1-, 2-, 3-, and 5-year survival rates were 88.1, 62.1, 48.9, and 42.1%, respectively. The 1-, 2-, 3-, and 5-year local control rates were 74.6, 61.9, 56.3, and 53.5%, respectively. There was no surgical mortality. The 3-year overall survival rates for recurrent T1, T2, T3, and T4 disease after surgery were 56, 61.1, 30.6, and 0%, respectively; the corresponding 5-year overall survival rates were 49.1, 24.7, 0, and 0%, respectively. Other prognostic factors with a negative effect on survival include lymph node metastasis, invasion of skull base and parapharyngeal space, and positive margin. CONCLUSIONS: Advances in skull base surgery make possible the effective control of primary recurrence of nasopharyngeal carcinoma for patients with rT1 and rT2 stages, with acceptable mortality and morbidity.
BACKGROUND:Nasopharyngeal carcinoma is sensitive to radiotherapy. When there is local relapse, re-irradiation treatment is inevitably associated with serious complications and decreased quality of life. Surgical resection offers an alternative treatment option with acceptable morbidity. METHODS: Seventy-one consecutive patients with primary recurrence of nasopharyngeal carcinoma after radiation underwent nasopharyngectomy from January 1, 1990 to June 30, 2006. Follow-up ranged from 12 to 127 months. RESULTS: The actuarial 1-, 2-, 3-, and 5-year survival rates were 88.1, 62.1, 48.9, and 42.1%, respectively. The 1-, 2-, 3-, and 5-year local control rates were 74.6, 61.9, 56.3, and 53.5%, respectively. There was no surgical mortality. The 3-year overall survival rates for recurrent T1, T2, T3, and T4 disease after surgery were 56, 61.1, 30.6, and 0%, respectively; the corresponding 5-year overall survival rates were 49.1, 24.7, 0, and 0%, respectively. Other prognostic factors with a negative effect on survival include lymph node metastasis, invasion of skull base and parapharyngeal space, and positive margin. CONCLUSIONS: Advances in skull base surgery make possible the effective control of primary recurrence of nasopharyngeal carcinoma for patients with rT1 and rT2 stages, with acceptable mortality and morbidity.
Authors: A W Lee; S C Law; W Foo; Y F Poon; F K Cheung; D K Chan; S Y Tung; M Thaw; J H Ho Journal: Int J Radiat Oncol Biol Phys Date: 1993-08-01 Impact factor: 7.038
Authors: Daniel T T Chua; Jonathan S T Sham; Philip W K Kwong; Kwan-Ngai Hung; Lucullus H T Leung Journal: Int J Radiat Oncol Biol Phys Date: 2003-05-01 Impact factor: 7.038
Authors: Edward W H To; Eric C H Lai; Jack H H Cheng; Peter C W Pang; Michael D Williams; Peter M L Teo Journal: Laryngoscope Date: 2002-10 Impact factor: 3.325