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Literature DB >> 21709101

Coresistance to isoniazid and ethionamide maps to mycothiol biosynthetic genes in Mycobacterium bovis.

Catherine Vilchèze¹, Yossef Av-Gay, S Whitney Barnes, Michelle H Larsen, John R Walker, Richard J Glynne, William R Jacobs.

Abstract

A search to identify new mechanisms of isoniazid resistance in Mycobacterium bovis led to the isolation of mutants defective in mycothiol biosynthesis due to mutations in genes coding for the glycosyltransferase (mshA) or the cysteine ligase (mshC). These mutants showed low-level resistance to isoniazid but were highly resistant to ethionamide. This study further illustrates that mutations in mycothiol biosynthesis genes may contribute to isoniazid or ethionamide resistance across mycobacterial species.

Entities: Chemical Species

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Year: 2011 PMID： 21709101 PMCID： PMC3165297 DOI： 10.1128/AAC.00564-11

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

15 in total

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Journal: Antimicrob Agents Chemother Date: 2006-08 Impact factor: 5.191

3. Mycothiol-deficient Mycobacterium smegmatis mutants are hypersensitive to alkylating agents, free radicals, and antibiotics.

Authors: Mamta Rawat; Gerald L Newton; Mary Ko; Gladys J Martinez; Robert C Fahey; Yossef Av-Gay
Journal: Antimicrob Agents Chemother Date: 2002-11 Impact factor: 5.191

4. Altered NADH/NAD+ ratio mediates coresistance to isoniazid and ethionamide in mycobacteria.

Authors: Catherine Vilchèze; Torin R Weisbrod; Bing Chen; Laurent Kremer; Manzour H Hazbón; Feng Wang; David Alland; James C Sacchettini; William R Jacobs
Journal: Antimicrob Agents Chemother Date: 2005-02 Impact factor: 5.191

5. Ethionamide activation and sensitivity in multidrug-resistant Mycobacterium tuberculosis.

Authors: A E DeBarber; K Mdluli; M Bosman; L G Bekker; C E Barry
Journal: Proc Natl Acad Sci U S A Date: 2000-08-15 Impact factor: 11.205

6. Activation of the pro-drug ethionamide is regulated in mycobacteria.

Authors: A R Baulard; J C Betts; J Engohang-Ndong; S Quan; R A McAdam; P J Brennan; C Locht; G S Besra
Journal: J Biol Chem Date: 2000-09-08 Impact factor: 5.157

7. Multicenter study of MTT and resazurin assays for testing susceptibility to first-line anti-tuberculosis drugs.

Authors: A Martin; N Morcillo; D Lemus; E Montoro; M A da Silva Telles; N Simboli; M Pontino; T Porras; C León; M Velasco; L Chacon; L Barrera; V Ritacco; F Portaels; J C Palomino
Journal: Int J Tuberc Lung Dis Date: 2005-08 Impact factor: 2.373

8. Efficacy and immunogenicity of Mycobacterium bovis DeltaRD1 against aerosol M. bovis infection in neonatal calves.

Authors: W Ray Waters; Mitchell V Palmer; Brian J Nonnecke; Tyler C Thacker; Charles F Capinos Scherer; D Mark Estes; R Glyn Hewinson; H Martin Vordermeier; S Whitney Barnes; Glenn C Federe; John R Walker; Richard J Glynne; Tsungda Hsu; Brian Weinrick; Karolin Biermann; Michelle H Larsen; William R Jacobs
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9. Genetic Manipulation of Mycobacterium tuberculosis.

Authors: Michelle H Larsen; Karolin Biermann; Steven Tandberg; Tsugunda Hsu; William R Jacobs
Journal: Curr Protoc Microbiol Date: 2007-08

10. Mycothiol biosynthesis is essential for ethionamide susceptibility in Mycobacterium tuberculosis.

Authors: Catherine Vilchèze; Yossef Av-Gay; Rodgoun Attarian; Zhen Liu; Manzour H Hazbón; Roberto Colangeli; Bing Chen; Weijun Liu; David Alland; James C Sacchettini; William R Jacobs
Journal: Mol Microbiol Date: 2008-07-21 Impact factor: 3.501

8 in total

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Journal: Antimicrob Agents Chemother Date: 2018-03-27 Impact factor: 5.191

2. Targeting Mycobacterium tuberculosis Sensitivity to Thiol Stress at Acidic pH Kills the Bacterium and Potentiates Antibiotics.

Authors: Garry B Coulson; Benjamin K Johnson; Huiqing Zheng; Christopher J Colvin; Robert J Fillinger; Elizabeth R Haiderer; Neal D Hammer; Robert B Abramovitch
Journal: Cell Chem Biol Date: 2017-08-03 Impact factor: 8.116

3. Enhanced respiration prevents drug tolerance and drug resistance in Mycobacterium tuberculosis.

Authors: Catherine Vilchèze; Travis Hartman; Brian Weinrick; Paras Jain; Torin R Weisbrod; Lawrence W Leung; Joel S Freundlich; William R Jacobs
Journal: Proc Natl Acad Sci U S A Date: 2017-04-10 Impact factor: 11.205

4. An upstream truncation of the furA-katG operon confers high-level isoniazid resistance in a Mycobacterium tuberculosis clinical isolate with no known resistance-associated mutations.

Authors: Gilman Kit Hang Siu; Wing Cheong Yam; Ying Zhang; Richard Y T Kao
Journal: Antimicrob Agents Chemother Date: 2014-08-04 Impact factor: 5.191