Literature DB >> 2170805

Different mechanisms of Ca2+ entry induced by depolarization and muscarinic receptor stimulation in SH-SY5Y human neuroblastoma cells.

D G Lambert1, E M Whitham, J G Baird, S R Nahorski.   

Abstract

Depolarization by elevated K+ and stimulation of muscarinic M3 receptors evoke rises in [Ca2+]i in Fura 2-loaded SH-SY5Y human neuroblastoma cells. The response to K+ (30 and 60 mM) could be inhibited by the dihydropyridine L-channel antagonist +PN 200-110 and totally suppressed by Ni2+, the N-channel blocker omega-conotoxin reduced the response to 60 mM K+. Carbachol-stimulated increase in [Ca2+]i was blocked by atropine and Ni2+ but was totally resistant to the L- and N-channel blockers. This study reveals the presence of L- and N-type voltage-sensitive Ca2+ channels on undifferentiated SH-SY5Y cells that are opened by K+ depolarization but not by muscarinic stimulation.

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Year:  1990        PMID： 2170805     DOI： 10.1016/0169-328x(90)90026-a

Source DB:  PubMed          Journal:  Brain Res Mol Brain Res        ISSN： 0169-328X


  13 in total

1.  Elevation of cytosolic calcium by cholinoceptor agonists in SH-SY5Y human neuroblastoma cells: estimation of the contribution of voltage-dependent currents.

Authors:  I D Forsythe; D G Lambert; S R Nahorski; P Lindsdell
Journal:  Br J Pharmacol       Date:  1992-09       Impact factor: 8.739

2.  Accumulation and metabolism of Ins(1,4,5)P3 and Ins(1,3,4,5)P4 in muscarinic-receptor-stimulated SH-SY5Y neuroblastoma cells.

Authors:  D G Lambert; R A Challiss; S R Nahorski
Journal:  Biochem J       Date:  1991-02-01       Impact factor: 3.857

3.  Characterization of two components of the N-like, high-threshold-activated calcium channel current in differentiated SH-SY5Y cells.

Authors:  E P Seward; G Henderson
Journal:  Pflugers Arch       Date:  1990-10       Impact factor: 3.657

4.  Effects of chronic drug treatments on increases in intracellular calcium mediated by nicotinic acetylcholine receptors in SH-SY5Y cells.

Authors:  Diana L Ridley; Jukka Pakkanen; Susan Wonnacott
Journal:  Br J Pharmacol       Date:  2002-02       Impact factor: 8.739

5.  Complex relationship between Ins(1,4,5)P3 accumulation and Ca2+ -signalling in a human neuroblastoma reveled by cellular differentiation.

Authors:  A K Martin; S R Nahorski; G B Willars
Journal:  Br J Pharmacol       Date:  1999-04       Impact factor: 8.739

6.  Activation of phospholipase C in SH-SY5Y neuroblastoma cells by potassium-induced calcium entry.

Authors:  D Smart; A Wandless; D G Lambert
Journal:  Br J Pharmacol       Date:  1995-09       Impact factor: 8.739

7.  Time-dependent effects of lithium on the agonist-stimulated accumulation of second messenger inositol 1,4,5-trisphosphate in SH-SY5Y human neuroblastoma cells.

Authors:  G V Los; I P Artemenko; L E Hokin
Journal:  Biochem J       Date:  1995-10-01       Impact factor: 3.857

8.  Studies on the mechanism of [3H]-noradrenaline release from SH-SY5Y cells: the role of Ca2+ and cyclic AMP.

Authors:  R Atcheson; D G Lambert; R A Hirst; D J Rowbotham
Journal:  Br J Pharmacol       Date:  1994-03       Impact factor: 8.739

9.  Mu-opioids activate phospholipase C in SH-SY5Y human neuroblastoma cells via calcium-channel opening.

Authors:  D Smart; G Smith; D G Lambert
Journal:  Biochem J       Date:  1995-01-15       Impact factor: 3.857

10.  Mechanistic and functional changes in Ca2+ entry after retinoic acid-induced differentiation of neuroblastoma cells.

Authors:  Anna M Brown; Fiona C Riddoch; Andrew Robson; Christopher P F Redfern; Timothy R Cheek
Journal:  Biochem J       Date:  2005-06-15       Impact factor: 3.857
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