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Literature DB >> 21706027

A pharmacological approach to first aid treatment for snakebite.

Megan E Saul¹, Paul A Thomas, Peter J Dosen, Geoffrey K Isbister, Margaret A O'Leary, Ian M Whyte, Sally A McFadden, Dirk F van Helden.

Abstract

Snake venom toxins first transit the lymphatic system before entering the bloodstream. Ointment containing a nitric oxide donor, which impedes the intrinsic lymphatic pump, prolonged lymph transit time in rats and humans and also increased rat survival time after injection of venom. This pharmacological approach should give snakebite victims more time to obtain medical care and antivenom treatment.

Entities: Chemical Species

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Year: 2011 PMID： 21706027 DOI： 10.1038/nm.2382

Source DB: PubMed Journal: Nat Med ISSN： 1078-8956 Impact factor: 53.440

15 in total

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16 in total

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5. Winner of the society for biomaterials young investigator award for the annual meeting of the society for biomaterials, April 11-14, 2018, Atlanta, GA: S-nitrosated poly(propylene sulfide) nanoparticles for enhanced nitric oxide delivery to lymphatic tissues.

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