| Literature DB >> 21705224 |
Theresa Meickle1, Sarath P Gunasekera, Yanxia Liu, Hendrik Luesch, Valerie J Paul.
Abstract
NMR-guided fractionation of a non-polar extract of a Florida Keys collection of Lyngbya sp. resulted in the isolation of two novel epimeric cyclic depsipeptides, porpoisamides A (1) and B (2). The planar structures of these compounds were determined using NMR spectroscopic techniques. The absolute configurations of amino and hydroxy acid subunits were assigned by enantioselective HPLC analysis. These compounds showed weak cytotoxicity towards HCT-116 colorectal carcinoma and U2OS osteosarcoma cells. The porpoisamides are a unique pair of cyclic depsipeptides that are epimeric at C-2 of the β-amino acid, 3-amino-2-methyloctanoic acid. Published by Elsevier Ltd.Entities:
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Year: 2011 PMID： 21705224 PMCID： PMC3197893 DOI： 10.1016/j.bmc.2011.05.051
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641