| Literature DB >> 12762800 |
Philip G Williams1, Wesley Y Yoshida, Michael K Quon, Richard E Moore, Valerie J Paul.
Abstract
Ulongapeptin (1), a cyclic depsipeptide, was isolated from a Palauan marine cyanobacterium Lyngbya sp. The gross structure was elucidated through one-dimensional TOCSY experiments and other spectroscopic techniques. The absolute and relative stereochemistry of the beta-amino acid, 3-amino-2-methyl-7-octynoic acid (AMO), in 1 was determined by synthesis of the saturated alpha-alkyl-beta-amino acid and Marfey's analysis of the acid hydrolysate of tetrahydro-1. Ulongapeptin (1) was cytotoxic against KB cells at an IC(50) value of 0.63 microM.Entities:
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Year: 2003 PMID： 12762800 DOI： 10.1021/np030050s
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050