Literature DB >> 21704212

Effects of metformin in adolescents with polycystic ovary syndrome undertaking lifestyle therapy: a pilot randomized double-blind study.

Gwinnett Ladson1, William C Dodson, Stephanie D Sweet, Anthony E Archibong, Allen R Kunselman, Laurence M Demers, Peter A Lee, Nancy I Williams, Ponjola Coney, Richard S Legro.   

Abstract

Our small study does not support the addition of metformin to the lifestyle of adolescents. Although there are favorable trends toward hyperandrogenism with metformin, these must be balanced against the increased rate of gastrointestinal side effects. However, other treatments were associated with an improved quality of life.
Copyright © 2011. Published by Elsevier Inc.

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Year:  2011        PMID： 21704212      PMCID： PMC3783023          DOI： 10.1016/j.fertnstert.2011.05.048

Source DB:  PubMed          Journal:  Fertil Steril        ISSN： 0015-0282            Impact factor:   7.329


  19 in total

1.  Impact of overweight on the risk of developing common chronic diseases during a 10-year period.

Authors:  A E Field; E H Coakley; A Must; J L Spadano; N Laird; W H Dietz; E Rimm; G A Colditz
Journal:  Arch Intern Med       Date:  2001-07-09

2.  Polycystic ovaries are common in women with hyperandrogenic chronic anovulation but do not predict metabolic or reproductive phenotype.

Authors:  Richard S Legro; Percy Chiu; Allen R Kunselman; Christina M Bentley; William C Dodson; Andrea Dunaif
Journal:  J Clin Endocrinol Metab       Date:  2005-02-15       Impact factor: 5.958

3.  Abdominal fat and insulin resistance in normal and overweight women: Direct measurements reveal a strong relationship in subjects at both low and high risk of NIDDM.

Authors:  D G Carey; A B Jenkins; L V Campbell; J Freund; D J Chisholm
Journal:  Diabetes       Date:  1996-05       Impact factor: 9.461

4.  The effects of metformin with lifestyle therapy in polycystic ovary syndrome: a randomized double-blind study.

Authors:  Gwinnett Ladson; William C Dodson; Stephanie D Sweet; Anthony E Archibong; Allen R Kunselman; Laurence M Demers; Nancy I Williams; Ponjola Coney; Richard S Legro
Journal:  Fertil Steril       Date:  2010-12-30       Impact factor: 7.329

5.  Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin.

Authors:  William C Knowler; Elizabeth Barrett-Connor; Sarah E Fowler; Richard F Hamman; John M Lachin; Elizabeth A Walker; David M Nathan
Journal:  N Engl J Med       Date:  2002-02-07       Impact factor: 91.245

6.  Hirsutism: implications, etiology, and management.

Authors:  R Hatch; R L Rosenfield; M H Kim; D Tredway
Journal:  Am J Obstet Gynecol       Date:  1981-08-01       Impact factor: 8.661

7.  Development of a health-related quality-of-life questionnaire (PCOSQ) for women with polycystic ovary syndrome (PCOS).

Authors:  L Cronin; G Guyatt; L Griffith; E Wong; R Azziz; W Futterweit; D Cook; A Dunaif
Journal:  J Clin Endocrinol Metab       Date:  1998-06       Impact factor: 5.958

8.  Insulin sensitization for girls with precocious pubarche and with risk for polycystic ovary syndrome: effects of prepubertal initiation and postpubertal discontinuation of metformin treatment.

Authors:  Lourdes Ibáñez; Carme Valls; Maria Victoria Marcos; Ken Ong; David B Dunger; Francis De Zegher
Journal:  J Clin Endocrinol Metab       Date:  2004-09       Impact factor: 5.958

Review 9.  Ultrasound assessment of the polycystic ovary: international consensus definitions.

Authors:  Adam H Balen; Joop S E Laven; Seang-Lin Tan; Didier Dewailly
Journal:  Hum Reprod Update       Date:  2003 Nov-Dec       Impact factor: 15.610

10.  A randomized, 48-week, placebo-controlled trial of intensive lifestyle modification and/or metformin therapy in overweight women with polycystic ovary syndrome: a pilot study.

Authors:  Kathleen M Hoeger; Lynda Kochman; Nellie Wixom; Kimberly Craig; Richard K Miller; David S Guzick
Journal:  Fertil Steril       Date:  2004-08       Impact factor: 7.329
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  10 in total

Review 1.  Depression and Anxiety in Polycystic Ovary Syndrome: Etiology and Treatment.

Authors:  Laura G Cooney; Anuja Dokras
Journal:  Curr Psychiatry Rep       Date:  2017-09-20       Impact factor: 5.285

Review 2.  Contemporary approaches to the management of polycystic ovary syndrome.

Authors:  Renato Pasquali
Journal:  Ther Adv Endocrinol Metab       Date:  2018-02-07       Impact factor: 3.565

3.  Metformin versus the combined oral contraceptive pill for hirsutism, acne, and menstrual pattern in polycystic ovary syndrome.

Authors:  Eloise Fraison; Elena Kostova; Lisa J Moran; Sophia Bilal; Carolyn C Ee; Christos Venetis; Michael F Costello
Journal:  Cochrane Database Syst Rev       Date:  2020-08-13

4.  Metabolic syndrome in obesity: treatment success and adverse pregnancy outcomes with ovulation induction in polycystic ovary syndrome.

Authors:  Sushila Arya; Karl R Hansen; Jennifer D Peck; Robert A Wild
Journal:  Am J Obstet Gynecol       Date:  2021-04-20       Impact factor: 10.693

5.  Effect of lifestyle intervention on the reproductive endocrine profile in women with polycystic ovarian syndrome: a systematic review and meta-analysis.

Authors:  Liza Haqq; James McFarlane; Gudrun Dieberg; Neil Smart
Journal:  Endocr Connect       Date:  2014-02-28       Impact factor: 3.335

Review 6.  Mental health and physical activity in women with polycystic ovary syndrome: a brief review.

Authors:  Francesca Conte; Lauren Banting; Helena J Teede; Nigel K Stepto
Journal:  Sports Med       Date:  2015-04       Impact factor: 11.136

7.  Diagnosis and treatment of polycystic ovary syndrome: an Endocrine Society clinical practice guideline.

Authors:  Richard S Legro; Silva A Arslanian; David A Ehrmann; Kathleen M Hoeger; M Hassan Murad; Renato Pasquali; Corrine K Welt
Journal:  J Clin Endocrinol Metab       Date:  2013-10-22       Impact factor: 5.958

Review 8.  Measures of health-related quality of life in PCOS women: a systematic review.

Authors:  Zahra Behboodi Moghadam; Bita Fereidooni; Mohsen Saffari; Ali Montazeri
Journal:  Int J Womens Health       Date:  2018-08-01

9.  Exercise, or exercise and diet for the management of polycystic ovary syndrome: a systematic review and meta-analysis.

Authors:  Chris Kite; Ian M Lahart; Islam Afzal; David R Broom; Harpal Randeva; Ioannis Kyrou; James E Brown
Journal:  Syst Rev       Date:  2019-02-12

10.  Effect of lifestyle modifications on anthropometric, clinical, and biochemical parameters in adolescent girls with polycystic ovary syndrome: a systematic review and meta-analysis.

Authors:  Somayeh Abdolahian; Fahimeh Ramezani Tehrani; Mina Amiri; Delaram Ghodsi; Razieh Bidhendi Yarandi; Mahdi Jafari; Hamid Alavi Majd; Fatemeh Nahidi
Journal:  BMC Endocr Disord       Date:  2020-05-19       Impact factor: 2.763
  10 in total

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