BACKGROUND & AIMS: IL28B polymorphisms have been associated with both treatment induced and spontaneous clearance of hepatitis C virus (HCV). We previously found that LDL cholesterol levels were higher in chronic hepatitis C (CHC) patients with the CC genotype at the rs12979860 polymorphism, located proximal to the IL28 gene. Here we analyzed the association of steatosis with IL28B genotype in treatment naïve patients with CHC. METHODS: Two independent cohorts of 145 genotype 1 infected patients from an antifibrotic study and 180 genotype 1 patients from Duke were analyzed for the presence and severity of steatosis in relation to the rs12979860 polymorphism at the IL28B locus. TaqMan assay based genotyping classified three groups CC, CT, and TT. RESULTS: CC genotype was associated with a lower prevalence of steatosis. In the antifibrotic study, steatosis was found in 47.6% (50/105) of IL28B non-CC vs. 22.5% (9/40; p=0.008) in CC patients. Similarly, steatosis was found in 67.4% (89/132) of non-CC patients compared to only 39.6% (19/48; p=0.001) of CC patients in the Duke cohort. CONCLUSIONS: IL28B CC genotype is associated with less pronounced disturbances of lipid metabolism, as reflected both in serum lipoprotein levels and hepatic steatosis, in HCV infection.
BACKGROUND & AIMS:IL28B polymorphisms have been associated with both treatment induced and spontaneous clearance of hepatitis C virus (HCV). We previously found that LDL cholesterol levels were higher in chronic hepatitis C (CHC) patients with the CC genotype at the rs12979860 polymorphism, located proximal to the IL28 gene. Here we analyzed the association of steatosis with IL28B genotype in treatment naïve patients with CHC. METHODS: Two independent cohorts of 145 genotype 1 infectedpatients from an antifibrotic study and 180 genotype 1 patients from Duke were analyzed for the presence and severity of steatosis in relation to the rs12979860 polymorphism at the IL28B locus. TaqMan assay based genotyping classified three groups CC, CT, and TT. RESULTS: CC genotype was associated with a lower prevalence of steatosis. In the antifibrotic study, steatosis was found in 47.6% (50/105) of IL28B non-CC vs. 22.5% (9/40; p=0.008) in CC patients. Similarly, steatosis was found in 67.4% (89/132) of non-CC patients compared to only 39.6% (19/48; p=0.001) of CC patients in the Duke cohort. CONCLUSIONS:IL28B CC genotype is associated with less pronounced disturbances of lipid metabolism, as reflected both in serum lipoprotein levels and hepatic steatosis, in HCV infection.
Authors: E Shinohara; S Yamashita; S Kihara; K Hirano; M Ishigami; T Arai; S Nozaki; K Kameda-Takemura; S Kawata; Y Matsuzawa Journal: Hepatology Date: 1997-06 Impact factor: 17.425
Authors: David R Nelson; Yves Benhamou; Wan-Long Chuang; Eric J Lawitz; Maribel Rodriguez-Torres; Robert Flisiak; Jens W F Rasenack; Wiesław Kryczka; Chuan-Mo Lee; Vincent G Bain; Stephen Pianko; Keyur Patel; Patrick W Cronin; Erik Pulkstenis; G Mani Subramanian; John G McHutchison Journal: Gastroenterology Date: 2010-07-01 Impact factor: 22.682
Authors: Hans L Tillmann; Alex J Thompson; Keyur Patel; Manfred Wiese; Hannelore Tenckhoff; Hans D Nischalke; Yuliya Lokhnygina; Ulrike Kullig; Uwe Göbel; Emanuela Capka; Johannes Wiegand; Ingolf Schiefke; Wolfgang Güthoff; Kurt Grüngreiff; Ingrid König; Ulrich Spengler; Jeanette McCarthy; Kevin V Shianna; David B Goldstein; John G McHutchison; Jörg Timm; Jacob Nattermann Journal: Gastroenterology Date: 2010-07-14 Impact factor: 22.682
Authors: John McHutchison; Zachary Goodman; Keyur Patel; Hala Makhlouf; Maribel Rodriguez-Torres; Mitchell Shiffman; Don Rockey; Petr Husa; Wan-Long Chuang; Robert Levine; Mark Jonas; Dickens Theodore; Richard Brigandi; Alison Webster; Margaret Schultz; Helen Watson; Britt Stancil; Stephen Gardner Journal: Gastroenterology Date: 2010-02-13 Impact factor: 22.682
Authors: J H Lefkowitch; E R Schiff; G L Davis; R P Perrillo; K Lindsay; H C Bodenheimer; L A Balart; T J Ortego; J Payne; J L Dienstag Journal: Gastroenterology Date: 1993-02 Impact factor: 22.682
Authors: Jessica D Tenenbaum; Victoria Christian; Melissa A Cornish; Rowena J Dolor; Ashley A Dunham; Geoffrey S Ginsburg; Virginia B Kraus; John G McHutchison; Meredith L Nahm; L Kristin Newby; Laura P Svetkey; Krishna Udayakumar; Robert M Califf Journal: Am J Transl Res Date: 2012-07-23 Impact factor: 4.060
Authors: A J Muir; L Gong; S G Johnson; M T M Lee; M S Williams; T E Klein; K E Caudle; D R Nelson Journal: Clin Pharmacol Ther Date: 2013-10-04 Impact factor: 6.875
Authors: Melanie E Garrett; Manal F Abdelmalek; Allison Ashley-Koch; Michael A Hauser; Cynthia A Moylan; Herbert Pang; Anna Mae Diehl; Hans L Tillmann Journal: J Hepatol Date: 2012-10-11 Impact factor: 25.083
Authors: Mazen Noureddin; Elizabeth C Wright; Harvey J Alter; Shauna Clark; Emmanuel Thomas; Richard Chen; Xiongce Zhao; Cathy Conry-Cantilena; David E Kleiner; T Jake Liang; Marc G Ghany Journal: Hepatology Date: 2013-09-30 Impact factor: 17.425