Literature DB >> 2170230

Inhibition of peptidoglycan biosynthesis in Bacillus megaterium by daptomycin.

D Mengin-Lecreulx1, N E Allen, J N Hobbs, J van Heijenoort.   

Abstract

The effects of daptomycin on exponential phase cells of Bacillus megaterium were investigated. Bacteriostasis was observed for concentrations between 1 and 3 micrograms/ml and maximal rate of cell lysis at 10 micrograms/ml. At sublytic concentrations (1.5-3 micrograms/ml), the variations of the pools of UDP-N-acetylglucosamine and UDP-N-acetylmuramyl-pentapeptide, as well as the incorporation of (14C)-N-acetylglucosamine into peptidoglycan were studied. From the results it was concluded that the lethal target of daptomycin could be a metabolic step between glucosamine 6-phosphate and UDP-N-acetylglucosamine.

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Year:  1990        PMID： 2170230     DOI： 10.1016/0378-1097(90)90074-z

Source DB:  PubMed          Journal:  FEMS Microbiol Lett        ISSN： 0378-1097            Impact factor:   2.742


  11 in total

1.  Katanosin B and plusbacin A(3), inhibitors of peptidoglycan synthesis in methicillin-resistant Staphylococcus aureus.

Authors:  H Maki; K Miura; Y Yamano
Journal:  Antimicrob Agents Chemother       Date:  2001-06       Impact factor: 5.191

2.  Characterization of the N-acetyl-α-D-glucosaminyl l-malate synthase and deacetylase functions for bacillithiol biosynthesis in Bacillus anthracis .

Authors:  Derek Parsonage; Gerald L Newton; Robert C Holder; Bret D Wallace; Carleitta Paige; Chris J Hamilton; Patricia C Dos Santos; Matthew R Redinbo; Sean D Reid; Al Claiborne
Journal:  Biochemistry       Date:  2010-09-28       Impact factor: 3.162

Review 3.  Mechanisms of drug resistance: daptomycin resistance.

Authors:  Truc T Tran; Jose M Munita; Cesar A Arias
Journal:  Ann N Y Acad Sci       Date:  2015-10-23       Impact factor: 5.691

4.  Impact of Bacterial Membrane Fatty Acid Composition on the Failure of Daptomycin To Kill Staphylococcus aureus.

Authors:  Rym Boudjemaa; Clément Cabriel; Florence Dubois-Brissonnet; Nicolas Bourg; Guillaume Dupuis; Alexandra Gruss; Sandrine Lévêque-Fort; Romain Briandet; Marie-Pierre Fontaine-Aupart; Karine Steenkeste
Journal:  Antimicrob Agents Chemother       Date:  2018-06-26       Impact factor: 5.191

Review 5.  Mechanism of Action and Resistance to Daptomycin in Staphylococcus aureus and Enterococci.

Authors:  William R Miller; Arnold S Bayer; Cesar A Arias
Journal:  Cold Spring Harb Perspect Med       Date:  2016-11-01       Impact factor: 6.915

6.  Daptomycin inhibits cell envelope synthesis by interfering with fluid membrane microdomains.

Authors:  Anna Müller; Michaela Wenzel; Henrik Strahl; Fabian Grein; Terrens N V Saaki; Bastian Kohl; Tjalling Siersma; Julia E Bandow; Hans-Georg Sahl; Tanja Schneider; Leendert W Hamoen
Journal:  Proc Natl Acad Sci U S A       Date:  2016-10-24       Impact factor: 11.205

7.  Inhibition of membrane potential-dependent amino acid transport by daptomycin.

Authors:  N E Allen; W E Alborn; J N Hobbs
Journal:  Antimicrob Agents Chemother       Date:  1991-12       Impact factor: 5.191

Review 8.  Mechanisms of daptomycin resistance in Staphylococcus aureus: role of the cell membrane and cell wall.

Authors:  Arnold S Bayer; Tanja Schneider; Hans-Georg Sahl
Journal:  Ann N Y Acad Sci       Date:  2012-12-05       Impact factor: 5.691

9.  The lipopeptide antibiotic Friulimicin B inhibits cell wall biosynthesis through complex formation with bactoprenol phosphate.

Authors:  T Schneider; K Gries; M Josten; I Wiedemann; S Pelzer; H Labischinski; H-G Sahl
Journal:  Antimicrob Agents Chemother       Date:  2009-01-21       Impact factor: 5.191

10.  Ca2+-Daptomycin targets cell wall biosynthesis by forming a tripartite complex with undecaprenyl-coupled intermediates and membrane lipids.

Authors:  Fabian Grein; Anna Müller; Katharina M Scherer; Xinliang Liu; Kevin C Ludwig; Anna Klöckner; Manuel Strach; Hans-Georg Sahl; Ulrich Kubitscheck; Tanja Schneider
Journal:  Nat Commun       Date:  2020-03-19       Impact factor: 14.919
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