BACKGROUND: Endometrial polyps commonly affect premenopausal and postmenopausal women and carry a small risk of cancer. Consensus guidelines to direct the management of women with endometrial polyps are lacking. We examined the risk of malignancy in symptomatic and asymptomatic women with endometrial polyps. METHODS: Institutional databases were analyzed to identify women with pathologically confirmed endometrial polyps diagnosed from 2002 to 2007. Demographic, clinical, and pathologic outcomes were reviewed. The most significant pathologic diagnosis was recorded for each subject. Endometrial hyperplasia and cancer were characterized as arising in the polyp or the adjacent endometrium. Factors associated with atypical hyperplasia and cancer were analyzed. RESULTS: A total of 1011 women with endometrial polyps were identified. On pathology review, 964 (95.4%) polyps were reported as benign, 13 (1.3%) as hyperplasia without atypia, 5 (0.5%) as hyperplasia with atypia, and 13 (1.3%) as endometrial cancer. The only clinical or demographic factor associated with atypical hyperplasia and cancer was menopausal status (P = .02). Among premenopausal women the risk of cancer or atypical hyperplasia was 0.9% in patients without bleeding and 1.0% in women with bleeding. In postmenopausal women cancer or atypical hyperplasia was found in 1.9% of patients without bleeding and in 3.8% of women with bleeding. CONCLUSIONS: The risk of endometrial cancer in women with endometrial polyps is 1.3%, while cancers confined to a polyp were found in only 0.3%. The risk is greatest in postmenopausal women with vaginal bleeding.
BACKGROUND:Endometrial polyps commonly affect premenopausal and postmenopausal women and carry a small risk of cancer. Consensus guidelines to direct the management of women with endometrial polyps are lacking. We examined the risk of malignancy in symptomatic and asymptomatic women with endometrial polyps. METHODS: Institutional databases were analyzed to identify women with pathologically confirmed endometrial polyps diagnosed from 2002 to 2007. Demographic, clinical, and pathologic outcomes were reviewed. The most significant pathologic diagnosis was recorded for each subject. Endometrial hyperplasia and cancer were characterized as arising in the polyp or the adjacent endometrium. Factors associated with atypical hyperplasia and cancer were analyzed. RESULTS: A total of 1011 women with endometrial polyps were identified. On pathology review, 964 (95.4%) polyps were reported as benign, 13 (1.3%) as hyperplasia without atypia, 5 (0.5%) as hyperplasia with atypia, and 13 (1.3%) as endometrial cancer. The only clinical or demographic factor associated with atypical hyperplasia and cancer was menopausal status (P = .02). Among premenopausal women the risk of cancer or atypical hyperplasia was 0.9% in patients without bleeding and 1.0% in women with bleeding. In postmenopausal womencancer or atypical hyperplasia was found in 1.9% of patients without bleeding and in 3.8% of women with bleeding. CONCLUSIONS: The risk of endometrial cancer in women with endometrial polyps is 1.3%, while cancers confined to a polyp were found in only 0.3%. The risk is greatest in postmenopausal women with vaginal bleeding.
Authors: Andrea Ciavattini; Jacopo DI Giuseppe; Nicolò Clemente; Lorenzo Moriconi; Giovanni Delli Carpini; Nina Montik; Laura Mazzanti Journal: Oncol Lett Date: 2016-02-04 Impact factor: 2.967
Authors: Megan A Clarke; Beverly J Long; Arena Del Mar Morillo; Marc Arbyn; Jamie N Bakkum-Gamez; Nicolas Wentzensen Journal: JAMA Intern Med Date: 2018-09-01 Impact factor: 21.873
Authors: Jesus S Jiménez-Lopez; Ana Granado-San Miguel; Alvaro Tejerizo-Garcia; Jose L Muñoz-Gonzalez; Gregorio Lopez-Gonzalez Journal: BMC Womens Health Date: 2015-02-22 Impact factor: 2.809
Authors: Navya Nair; Olga Camacho-Vanegas; Dmitry Rykunov; Matthew Dashkoff; Sandra Catalina Camacho; Cassie A Schumacher; Jonathan C Irish; Timothy T Harkins; Elijah Freeman; Isaac Garcia; Elena Pereira; Sviatoslav Kendall; Rachel Belfer; Tamara Kalir; Robert Sebra; Boris Reva; Peter Dottino; John A Martignetti Journal: PLoS Med Date: 2016-12-27 Impact factor: 11.069