OBJECTIVES: We aimed to evaluate the performance of diffusion-weighted magnetic resonance imaging in differentiating malignant from benign mediastinal lesions. METHODS: Fifty-three mediastinal lesions were examined with T1- and T2-weighted (W) conventional images. Then, two diffusion-weighted images were obtained with b = 0 and 1000 s/mm² values and apparent diffusion coefficients (ADC) were calculated. The statistical significance of differences between measurements was tested using the Student-t test. RESULTS: The mean ADC of malignant lesions was significantly lower than that of the benign masses (p < 0.001). The cut-off value of ≤ 1.39 × 10(-3) mm²/s indicated a malignant lesion with a sensitivity of 95% and specificity of 87%. CONCLUSION: Diffusion-weighted imaging may be helpful in differentiating benign from malignant mediastinal masses.
OBJECTIVES: We aimed to evaluate the performance of diffusion-weighted magnetic resonance imaging in differentiating malignant from benign mediastinal lesions. METHODS: Fifty-three mediastinal lesions were examined with T1- and T2-weighted (W) conventional images. Then, two diffusion-weighted images were obtained with b = 0 and 1000 s/mm² values and apparent diffusion coefficients (ADC) were calculated. The statistical significance of differences between measurements was tested using the Student-t test. RESULTS: The mean ADC of malignant lesions was significantly lower than that of the benign masses (p < 0.001). The cut-off value of ≤ 1.39 × 10(-3) mm²/s indicated a malignant lesion with a sensitivity of 95% and specificity of 87%. CONCLUSION: Diffusion-weighted imaging may be helpful in differentiating benign from malignant mediastinal masses.
Authors: Kyung Eun Shin; Chin A Yi; Tae Sung Kim; Ho Yun Lee; Young Soo Choi; Hong Kwan Kim; Jhingook Kim Journal: Eur Radiol Date: 2013-11-01 Impact factor: 5.315
Authors: Moti Freiman; Stephan D Voss; Robert V Mulkern; Jeannette M Perez-Rossello; Michael J Callahan; Simon K Warfield Journal: Med Phys Date: 2012-08 Impact factor: 4.071