Literature DB >> 2169300

Cytomegalovirus infection of adipose tissues induces steatitis in adult mice.

P Price1, K S Eddy, J M Papadimitriou, T A Robertson, G R Shellam.   

Abstract

Young adult mice infected with MCMV were shown to develop inflammatory lesions in the peripancreatic and salivary gland adipose tissues. MCMV replication was detected by immunoperoxidase staining and electron microscopy in adipocytes, fibroblasts, endothelial cells and pericytes in brown and white adipose tissues. More infected cells were detected in C3H mice than in BALB/c, BALB.B, BALB.K or C57BL/6 mice. Peripancreatic steatitis consisted of a monocytic infiltrate surrounding focal necrosis of adipocytes, the severity of which was influenced by the route of inoculation, virus dose, and genetic susceptibility to disseminated MCMV-disease. C57BL/6 mice showed the greatest susceptibility with severe coalescing focal inflammation around areas of coagulative necrosis. Salivary gland adipose tissues exhibited lymphocytic steatitis, which was reduced in Nu/Nu mice.

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Mesh：

Year:  1990        PMID： 2169300      PMCID： PMC2002283     

Source DB:  PubMed          Journal:  Int J Exp Pathol        ISSN： 0959-9673            Impact factor:   1.925


  15 in total

1.  Splenic necrosis in mice infected with cytomegalovirus.

Authors:  C A Mims; J Gould
Journal:  J Infect Dis       Date:  1978-05       Impact factor: 5.226

2.  Functional changes in murine macrophages infected with cytomegalovirus relate to H-2-determined sensitivity to infection.

Authors:  P Price; J G Winter; S Nikoletti; J B Hudson; G R Shellam
Journal:  J Virol       Date:  1987-11       Impact factor: 5.103

3.  Steatitis in mice infected with Coxsackie virus B3.

Authors:  I Hashimoto; M Tomita; T Kohara; I Uchino; A Harasima
Journal:  Microbiol Immunol       Date:  1985       Impact factor: 1.955

4.  Presence of cytomegalovirus in brown fat. Study in a rat model.

Authors:  C A Bruggeman; J H Bruning; G Grauls; A E van den Bogaard; F Bosman
Journal:  Intervirology       Date:  1987       Impact factor: 1.763

5.  Pathogenesis of acute murine cytomegalovirus infection in resistant and susceptible strains of mice.

Authors:  J A Mercer; D H Spector
Journal:  J Virol       Date:  1986-02       Impact factor: 5.103

6.  The role of T cells in mouse cytomegalovirus myocarditis.

Authors:  C M Lawson; H O'Donoghue; W D Reed
Journal:  Immunology       Date:  1989-05       Impact factor: 7.397

7.  Variation in murine cytomegalovirus replication in fibroblasts from different mouse strains in vitro: correlation with in vivo resistance.

Authors:  G B Harnett; G R Shellam
Journal:  J Gen Virol       Date:  1982-09       Impact factor: 3.891

8.  Resistance to murine cytomegalovirus linked to the major histocompatibility complex of the mouse.

Authors:  J E Chalmer; J S Mackenzie; N F Stanley
Journal:  J Gen Virol       Date:  1977-10       Impact factor: 3.891

9.  Effect of Nu/Nu gene on genetically determined resistance to murine cytomegalovirus.

Authors:  J E Grundy; C J Melief
Journal:  J Gen Virol       Date:  1982-07       Impact factor: 3.891

10.  Host genetic factors influence murine cytomegalovirus lung infection and interstitial pneumonitis.

Authors:  J D Shanley
Journal:  J Gen Virol       Date:  1984-12       Impact factor: 3.891
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  9 in total

1.  Effect of a retroviral immunodeficiency syndrome on murine cytomegalovirus-induced hepatitis.

Authors:  C D Peacock; S D Olver; P Price
Journal:  Am J Pathol       Date:  1997-03       Impact factor: 4.307

2.  Genetic determination of cytomegalovirus-induced and age-related cardiopathy in inbred mice. Characterization of infiltrating cells.

Authors:  P Price; K S Eddy; J M Papadimitriou; D L Faulkner; G R Shellam
Journal:  Am J Pathol       Date:  1991-01       Impact factor: 4.307

3.  Human cytomegalovirus infection of human adipose-derived stromal/stem cells restricts differentiation along the adipogenic lineage.

Authors:  K J Zwezdaryk; M B Ferris; A L Strong; C A Morris; B A Bunnell; N V Dhurandhar; J M Gimble; D E Sullivan
Journal:  Adipocyte       Date:  2015-12-09       Impact factor: 4.534

Review 4.  Clinical consequences of asymptomatic cytomegalovirus in treated human immunodeficency virus infection.

Authors:  Samuel R Schnittman; Peter W Hunt
Journal:  Curr Opin HIV AIDS       Date:  2021-05-01       Impact factor: 4.283

5.  Infection and upregulation of proinflammatory cytokines in human brain vascular pericytes by human cytomegalovirus.

Authors:  Donald J Alcendor; Ashley M Charest; Wen Qin Zhu; Hollie E Vigil; Susan M Knobel
Journal:  J Neuroinflammation       Date:  2012-05-18       Impact factor: 8.322

6.  Life-long control of cytomegalovirus (CMV) by T resident memory cells in the adipose tissue results in inflammation and hyperglycemia.

Authors:  Nico A Contreras; Katarzyna M Sitnik; Ilija Jeftic; Christopher Patrick Coplen; Luka Čičin-Šain; Janko Nikolich-Žugich
Journal:  PLoS Pathog       Date:  2019-06-20       Impact factor: 6.823

7.  Polyinosinic: Polycytidylic Acid and Murine Cytomegalovirus Modulate Expression of Murine IL-10 and IL-21 in White Adipose Tissue.

Authors:  Pablo Garcia-Valtanen; Ruth Marian Guzman-Genuino; John D Hayball; Kerrilyn R Diener
Journal:  Viruses       Date:  2020-05-22       Impact factor: 5.048

Review 8.  Adipose Tissue T Cells in HIV/SIV Infection.

Authors:  Celestine N Wanjalla; Wyatt J McDonnell; John R Koethe
Journal:  Front Immunol       Date:  2018-12-03       Impact factor: 7.561

Review 9.  Specific Biological Features of Adipose Tissue, and Their Impact on HIV Persistence.

Authors:  Christine Bourgeois; Jennifer Gorwood; Aurélie Barrail-Tran; Claire Lagathu; Jacqueline Capeau; Delphine Desjardins; Roger Le Grand; Abderaouf Damouche; Véronique Béréziat; Olivier Lambotte
Journal:  Front Microbiol       Date:  2019-12-17       Impact factor: 5.640
  9 in total

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