Literature DB >> 27144097

Human cytomegalovirus infection of human adipose-derived stromal/stem cells restricts differentiation along the adipogenic lineage.

K J Zwezdaryk1, M B Ferris1, A L Strong2, C A Morris1, B A Bunnell3, N V Dhurandhar4, J M Gimble5, D E Sullivan6.   

Abstract

Human adipose-derived stromal/stem cells (ASCs) display potential to be used in regenerative stem cell therapies and as treatments for inflammatory and autoimmune disorders. Despite promising use of ASCs as therapeutics, little is known about their susceptibility to infectious agents. In this study, we demonstrate that ASCs are highly susceptible to human cytomegalovirus (HCMV) infection and permissive for replication leading to release of infectious virions. Additionally, many basic ASC functions are inhibited during HCMV infection, such as differentiation and immunomodulatory potential. To our knowledge this is the first study examining potential adverse effects of HCMV infection on ASC biology. Our results suggest, that an active HCMV infection during ASC therapy may result in a poor clinical outcome due to interference by the virus.

Entities:  

Keywords:  Adipogenesis; adipose stem cell; cytomegalovirus; herpesvirus

Year:  2015        PMID： 27144097      PMCID： PMC4836472          DOI： 10.1080/21623945.2015.1119957

Source DB:  PubMed          Journal:  Adipocyte        ISSN： 2162-3945            Impact factor:   4.534


  51 in total

1.  Action at a distance: systemically administered adult stem/progenitor cells (MSCs) reduce inflammatory damage to the cornea without engraftment and primarily by secretion of TNF-α stimulated gene/protein 6.

Authors:  Gavin W Roddy; Joo Youn Oh; Ryang Hwa Lee; Thomas J Bartosh; Joni Ylostalo; Katie Coble; Robert H Rosa; Darwin J Prockop
Journal:  Stem Cells       Date:  2011-10       Impact factor: 6.277

Review 2.  Adipose-derived stem cells: characterization and current application in orthopaedic tissue repair.

Authors:  Hazel Tapp; Edward N Hanley; Joshua C Patt; Helen E Gruber
Journal:  Exp Biol Med (Maywood)       Date:  2009-01

3.  Human cytomegalovirus infection of human embryonic stem cell-derived primitive neural stem cells is restricted at several steps but leads to the persistence of viral DNA.

Authors:  Jean-Philippe Belzile; Thomas J Stark; Gene W Yeo; Deborah H Spector
Journal:  J Virol       Date:  2014-01-22       Impact factor: 5.103

4.  Presence of cytomegalovirus in brown fat. Study in a rat model.

Authors:  C A Bruggeman; J H Bruning; G Grauls; A E van den Bogaard; F Bosman
Journal:  Intervirology       Date:  1987       Impact factor: 1.763

5.  Mesenchymal stem cells are susceptible to human herpesviruses, but viral DNA cannot be detected in the healthy seropositive individual.

Authors:  M Sundin; C Orvell; I Rasmusson; B Sundberg; O Ringdén; K Le Blanc
Journal:  Bone Marrow Transplant       Date:  2006-06       Impact factor: 5.483

6.  Activation of EGFR on monocytes is required for human cytomegalovirus entry and mediates cellular motility.

Authors:  Gary Chan; Maciej T Nogalski; Andrew D Yurochko
Journal:  Proc Natl Acad Sci U S A       Date:  2009-12-11       Impact factor: 11.205

7.  Platelet-derived growth factor-alpha receptor activation is required for human cytomegalovirus infection.

Authors:  Liliana Soroceanu; Armin Akhavan; Charles S Cobbs
Journal:  Nature       Date:  2008-08-13       Impact factor: 49.962

8.  Stromal cells from the adipose tissue-derived stromal vascular fraction and culture expanded adipose tissue-derived stromal/stem cells: a joint statement of the International Federation for Adipose Therapeutics and Science (IFATS) and the International Society for Cellular Therapy (ISCT).

Authors:  Philippe Bourin; Bruce A Bunnell; Louis Casteilla; Massimo Dominici; Adam J Katz; Keith L March; Heinz Redl; J Peter Rubin; Kotaro Yoshimura; Jeffrey M Gimble
Journal:  Cytotherapy       Date:  2013-04-06       Impact factor: 5.414

9.  New concepts on the immune modulation mediated by mesenchymal stem cells.

Authors:  Bruce A Bunnell; Aline M Betancourt; Deborah E Sullivan
Journal:  Stem Cell Res Ther       Date:  2010-11-11       Impact factor: 6.832

10.  Is adipose tissue a place for Mycobacterium tuberculosis persistence?

Authors:  Olivier Neyrolles; Rogelio Hernández-Pando; France Pietri-Rouxel; Paul Fornès; Ludovic Tailleux; Jorge Alberto Barrios Payán; Elisabeth Pivert; Yann Bordat; Diane Aguilar; Marie-Christine Prévost; Caroline Petit; Brigitte Gicquel
Journal:  PLoS One       Date:  2006-12-20       Impact factor: 3.240
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  11 in total

Review 1.  HIV Persistence in Adipose Tissue Reservoirs.

Authors:  Jacob Couturier; Dorothy E Lewis
Journal:  Curr HIV/AIDS Rep       Date:  2018-02       Impact factor: 5.071

2.  Mesenteric injection of adipose-derived mesenchymal stem cells relieves experimentally-induced colitis in rats by regulating Th17/Treg cell balance.

Authors:  Zheng-Wei Fu; Zhen-Yu Zhang; Hai-Yan Ge
Journal:  Am J Transl Res       Date:  2018-01-15       Impact factor: 4.060

Review 3.  Bone Marrow Adipocyte Developmental Origin and Biology.

Authors:  Joanna Bukowska; Trivia Frazier; Stanley Smith; Theodore Brown; Robert Bender; Michelle McCarthy; Xiying Wu; Bruce A Bunnell; Jeffrey M Gimble
Journal:  Curr Osteoporos Rep       Date:  2018-06       Impact factor: 5.096

Review 4.  Tissue Immunometabolism: Development, Physiology, and Pathobiology.

Authors:  Kevin Man; Vassily I Kutyavin; Ajay Chawla
Journal:  Cell Metab       Date:  2016-09-29       Impact factor: 27.287

5.  Life-long control of cytomegalovirus (CMV) by T resident memory cells in the adipose tissue results in inflammation and hyperglycemia.

Authors:  Nico A Contreras; Katarzyna M Sitnik; Ilija Jeftic; Christopher Patrick Coplen; Luka Čičin-Šain; Janko Nikolich-Žugich
Journal:  PLoS Pathog       Date:  2019-06-20       Impact factor: 6.823

6.  Single-cell analysis shows that adipose tissue of persons with both HIV and diabetes is enriched for clonal, cytotoxic, and CMV-specific CD4+ T cells.

Authors:  Celestine N Wanjalla; Wyatt J McDonnell; Ramesh Ram; Abha Chopra; Rama Gangula; Shay Leary; Mona Mashayekhi; Joshua D Simmons; Christian M Warren; Samuel Bailin; Curtis L Gabriel; Liang Guo; Briana D Furch; Morgan C Lima; Beverly O Woodward; LaToya Hannah; Mark A Pilkinton; Daniela T Fuller; Kenji Kawai; Renu Virmani; Aloke V Finn; Alyssa H Hasty; Simon A Mallal; Spyros A Kalams; John R Koethe
Journal:  Cell Rep Med       Date:  2021-02-16

Review 7.  Is Adipose Tissue a Reservoir for Viral Spread, Immune Activation, and Cytokine Amplification in Coronavirus Disease 2019?

Authors:  Paul MacDaragh Ryan; Noel M Caplice
Journal:  Obesity (Silver Spring)       Date:  2020-05-31       Impact factor: 9.298

8.  Isolation, Characterization, Differentiation and Immunomodulatory Capacity of Mesenchymal Stromal/Stem Cells from Human Perirenal Adipose Tissue.

Authors:  Patrick C Baer; Benjamin Koch; Elena Hickmann; Ralf Schubert; Jindrich Cinatl; Ingeborg A Hauser; Helmut Geiger
Journal:  Cells       Date:  2019-10-29       Impact factor: 6.600

9.  The Thrombopoietin Receptor Agonist Eltrombopag Inhibits Human Cytomegalovirus Replication Via Iron Chelation.

Authors:  Jens-Uwe Vogel; Sophie Schmidt; Daniel Schmidt; Florian Rothweiler; Benjamin Koch; Patrick Baer; Holger Rabenau; Detlef Michel; Thomas Stamminger; Martin Michaelis; Jindrich Cinatl
Journal:  Cells       Date:  2019-12-20       Impact factor: 6.600

Review 10.  Pathways to Severe COVID-19 for People with Obesity.

Authors:  Robert W O'Rourke; Carey N Lumeng
Journal:  Obesity (Silver Spring)       Date:  2021-04       Impact factor: 9.298
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