AIM: The study assessed the clinicopathological features and survival rates of inflammatory bowel disease (IBD) patients with colorectal carcinoma (CRC), which accounts for ∼ 15% of all IBD associated death. METHOD: The medical records of patients operated on for CRC in three institutions between 1992 and 2009 were reviewed, and those with Crohn's colitis (CC) and ulcerative colitis (UC) were identified. Data on age, gender, disease duration, colitis severity, surgical procedure, tumour stage and survival were retrieved. RESULTS: Fifty-three patients (40 UC and 13 CC, 27 men, mean age at operation 54 years) were found. All parameters were comparable between the groups. Mean disease duration before CRC was 22.7 years for UC and 16.6 years for CC patients (P = 0.04). CRC was diagnosed preoperatively in 43 (81%) patients. Twenty-eight patients had colon cancer, 23 had rectal cancer and two patients had more than one cancer. All malignancies were located in segments with colitis. Over one-half were diagnosed at an advanced stage (36% stage III; 17% stage IV). At a mean follow up of 56 ± 65 months, 60% were alive (54% disease free) and 40% were dead from cancer-related causes. The 5-year survival rate was 61% for the UC and 37% for the CC patients (P = NS). CONCLUSION: CRC in IBD patients is frequently diagnosed at an advanced stage, a factor that contributes to poor prognosis. The risk of CRC in CC patients is comparable to those with UC. Long-term surveillance is recommended for patients with long-standing CC and UC.
AIM: The study assessed the clinicopathological features and survival rates of inflammatory bowel disease (IBD) patients with colorectal carcinoma (CRC), which accounts for ∼ 15% of all IBD associated death. METHOD: The medical records of patients operated on for CRC in three institutions between 1992 and 2009 were reviewed, and those with Crohn's colitis (CC) and ulcerative colitis (UC) were identified. Data on age, gender, disease duration, colitis severity, surgical procedure, tumour stage and survival were retrieved. RESULTS: Fifty-three patients (40 UC and 13 CC, 27 men, mean age at operation 54 years) were found. All parameters were comparable between the groups. Mean disease duration before CRC was 22.7 years for UC and 16.6 years for CC patients (P = 0.04). CRC was diagnosed preoperatively in 43 (81%) patients. Twenty-eight patients had colon cancer, 23 had rectal cancer and two patients had more than one cancer. All malignancies were located in segments with colitis. Over one-half were diagnosed at an advanced stage (36% stage III; 17% stage IV). At a mean follow up of 56 ± 65 months, 60% were alive (54% disease free) and 40% were dead from cancer-related causes. The 5-year survival rate was 61% for the UC and 37% for the CC patients (P = NS). CONCLUSION: CRC in IBD patients is frequently diagnosed at an advanced stage, a factor that contributes to poor prognosis. The risk of CRC in CC patients is comparable to those with UC. Long-term surveillance is recommended for patients with long-standing CC and UC.
Authors: Bernhard W Renz; Wolfgang E Thasler; Gerhard Preissler; Tobias Heide; Philippe N Khalil; Michael Mikhailov; Karl-Walter Jauch; Martin E Kreis; Markus Rentsch; Axel Kleespies Journal: J Gastrointest Surg Date: 2013-03-09 Impact factor: 3.452
Authors: Francesco Roscio; Camillo Bertoglio; Antonio De Luca; Paolo Frattini; Federico Clerici; Ildo Scandroglio Journal: Updates Surg Date: 2012-06-28
Authors: D O Kavanagh; M C Carter; D Keegan; G Doherty; M J Smith; J M P Hyland; H Mulcahy; K Sheahan; P R O' Connell; D P O' Donoghue; D C Winter Journal: Tech Coloproctol Date: 2013-02-14 Impact factor: 3.781
Authors: Alexandru V Olaru; Sumitaka Yamanaka; Christine Vazquez; Yuriko Mori; Yulan Cheng; John M Abraham; Theodore M Bayless; Noam Harpaz; Florin M Selaru; Stephen J Meltzer Journal: Inflamm Bowel Dis Date: 2013-03 Impact factor: 5.325
Authors: Jochen K Lennerz; Kimberley W J van der Sloot; Long Phi Le; Julie M Batten; Jae Young Han; Kenneth C Fan; Corey A Siegel; Amitabh Srivastava; Do Youn Park; Jey-Hsin Chen; Bruce E Sands; Joshua R Korzenik; Robert D Odze; Dora Dias-Santagata; Darrell R Borger; Hamed Khalili; A John Iafrate; Gregory Y Lauwers Journal: Int J Colorectal Dis Date: 2016-03-30 Impact factor: 2.571