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Literature DB >> 21686238

Evolution of synthetic polymers.

Abstract

A strategy for the enrichment of a DNA template that encodes a functionalized PNA oligomer is discussed. The method relies on iterated cycles of chemical translation (of the template into PNA), selection (for function), and amplification (of the survivors). Potential restrictions and future perspectives are considered.

Entities: Chemical

Year: 2010 PMID： 21686238 PMCID： PMC3116572 DOI： 10.4161/adna.1.2.13501

Source DB: PubMed Journal: Artif DNA PNA XNA ISSN： 1949-095X

Keyword Cloud
References

19 in total

1. Crystal structure of a partly self-complementary peptide nucleic acid (PNA) oligomer showing a duplex-triplex network.

Authors: Britt Petersson; Bettina Bryde Nielsen; Hanne Rasmussen; Ingrid Kjøller Larsen; Michael Gajhede; Peter E Nielsen; Jette Sandholm Kastrup
Journal: J Am Chem Soc Date: 2005-02-09 Impact factor: 15.419

2. As fast and selective as enzymatic ligations: unpaired nucleobases increase the selectivity of DNA-controlled native chemical PNA ligation.

Authors: Simon Ficht; Christian Dose; Oliver Seitz
Journal: Chembiochem Date: 2005-11 Impact factor: 3.164

3. Gamma-substituted peptide nucleic acids constructed from L-lysine are a versatile scaffold for multifunctional display.

Authors: Ethan A Englund; Daniel H Appella
Journal: Angew Chem Int Ed Engl Date: 2007 Impact factor: 15.336

4. Nucleic acid templated reactions: consequences of probe reactivity and readout strategy for amplified signaling and sequence selectivity.

Authors: Tom N Grossmann; Oliver Seitz
Journal: Chemistry Date: 2009-07-06 Impact factor: 5.236

Evolution of synthetic polymers.

1. Crystal structure of a partly self-complementary peptide nucleic acid (PNA) oligomer showing a duplex-triplex network.

2. As fast and selective as enzymatic ligations: unpaired nucleobases increase the selectivity of DNA-controlled native chemical PNA ligation.

3. Gamma-substituted peptide nucleic acids constructed from L-lysine are a versatile scaffold for multifunctional display.

4. Nucleic acid templated reactions: consequences of probe reactivity and readout strategy for amplified signaling and sequence selectivity.

5. RNA-peptide fusions for the in vitro selection of peptides and proteins.

6. Molding a peptide into an RNA site by in vivo peptide evolution.

7. Template switching between PNA and RNA oligonucleotides.

Review 8. An introduction to peptide nucleic acid.

9. An in vitro translation, selection and amplification system for peptide nucleic acids.

Review 10. Recent progress toward the templated synthesis and directed evolution of sequence-defined synthetic polymers.