Literature DB >> 21682322

Synthesis of substituted pyrazoles via tandem cross-coupling/electrocyclization of enol triflates and diazoacetates.

David J Babinski1, Hector R Aguilar, Raymond Still, Doug E Frantz.   

Abstract

The synthesis of 3,4,5-trisubstituted pyrazoles via a tandem catalytic cross-coupling/electrocyclization of enol triflates and diazoacetates is presented. The initial scope of this methodology is demonstrated on a range of differentially substituted acyclic and cyclic enol triflates as well as an elaborated set of diazoacetates to provide the corresponding pyrazoles with a high degree of structural complexity.

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Year:  2011        PMID： 21682322      PMCID： PMC3155889          DOI： 10.1021/jo201042c

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  27 in total

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Journal:  J Org Chem       Date:  2008-04-30       Impact factor: 4.354

7.  Stereoselective synthesis of acetoacetate-derived enol triflates.

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Journal:  Org Lett       Date:  2008-06-10       Impact factor: 6.005

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10.  Design of annulated pyrazoles as inhibitors of HIV-1 reverse transcriptase.

Authors:  Zachary K Sweeney; Seth F Harris; Seth F Arora; Hassan Javanbakht; Yu Li; Jennifer Fretland; James P Davidson; J Roland Billedeau; Shelley K Gleason; Donald Hirschfeld; Joshua J Kennedy-Smith; Taraneh Mirzadegan; Ralf Roetz; Mark Smith; Sarah Sperry; Judy M Suh; Jeffrey Wu; Stan Tsing; Armando G Villaseñor; Amber Paul; Guoping Su; Gabrielle Heilek; Julie Q Hang; Amy S Zhou; Jesper A Jernelius; Fang-Jie Zhang; Klaus Klumpp
Journal:  J Med Chem       Date:  2008-12-11       Impact factor: 7.446
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4.  Synthesis of highly functionalized tri- and tetrasubstituted alkenes via Pd-catalyzed 1,2-hydrovinylation of terminal 1,3-dienes.

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