Literature DB >> 2168169

Membrane topology of microsomal cytochrome P-450: saturation transfer EPR and freeze-fracture electron microscopy studies.

D Schwarz1, J Pirrwitz, H W Meyer, M J Coon, K Ruckpaul.   

Abstract

The rotation of cytochrome P-450 LM2 (CYPIIB4) incorporated into large microsomal-like lipid vesicles was investigated by saturation transfer EPR using 15N- and 2H-substituted spin labels. In combination with rotational diffusion, the distribution and size of protein particles in the bilayer were studied by freeze-fracture electron microscopy. The data from both methods suggest an oligomeric and membrane-spanning aggregate for the topology of microsomal cytochrome P-450.

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Year:  1990        PMID： 2168169     DOI： 10.1016/0006-291x(90)91373-z

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  15 in total

1.  Interactions among cytochromes P450 in microsomal membranes: oligomerization of cytochromes P450 3A4, 3A5, and 2E1 and its functional consequences.

Authors:  Dmitri R Davydov; Nadezhda Y Davydova; Elena V Sineva; James R Halpert
Journal:  J Biol Chem       Date:  2014-12-22       Impact factor: 5.157

Review 2.  Allosteric P450 mechanisms: multiple binding sites, multiple conformers or both?

Authors:  Dmitri R Davydov; James R Halpert
Journal:  Expert Opin Drug Metab Toxicol       Date:  2008-12       Impact factor: 4.481

3.  Role of subunit interactions in P450 oligomers in the loss of homotropic cooperativity in the cytochrome P450 3A4 mutant L211F/D214E/F304W.

Authors:  Harshica Fernando; Dmitri R Davydov; Christopher C Chin; James R Halpert
Journal:  Arch Biochem Biophys       Date:  2007-01-12       Impact factor: 4.013

4.  Mobility of cytochrome P450 in the endoplasmic reticulum membrane.

Authors:  E Szczesna-Skorupa; C D Chen; S Rogers; B Kemper
Journal:  Proc Natl Acad Sci U S A       Date:  1998-12-08       Impact factor: 11.205

Review 5.  Cytochromes P450 in nanodiscs.

Authors:  Ilia G Denisov; Stephen G Sligar
Journal:  Biochim Biophys Acta       Date:  2010-06-08

6.  Electron transfer in the complex of membrane-bound human cytochrome P450 3A4 with the flavin domain of P450BM-3: the effect of oligomerization of the heme protein and intermittent modulation of the spin equilibrium.

Authors:  Dmitri R Davydov; Elena V Sineva; Srinivas Sistla; Nadezhda Y Davydova; Daniel J Frank; Stephen G Sligar; James R Halpert
Journal:  Biochim Biophys Acta       Date:  2009-12-21

Review 7.  Formation of P450 · P450 complexes and their effect on P450 function.

Authors:  James R Reed; Wayne L Backes
Journal:  Pharmacol Ther       Date:  2011-11-29       Impact factor: 12.310

8.  Heterogeneity in rabbit liver cytochrome P-450 LM2 observed by cation exchange HPLC: partial biochemical characterization of the two major LM2 subfractions.

Authors:  H A Garda; V Krüger; J Sidhu; A Stier
Journal:  Mol Cell Biochem       Date:  1994-12-07       Impact factor: 3.396

9.  Effect of glutathione on homo- and heterotropic cooperativity in cytochrome P450 3A4.

Authors:  Dmitri R Davydov; Nadezhda Y Davydova; Tamara N Tsalkova; James R Halpert
Journal:  Arch Biochem Biophys       Date:  2008-01-11       Impact factor: 4.013

10.  Domain-Swap Dimerization of Acanthamoeba castellanii CYP51 and a Unique Mechanism of Inactivation by Isavuconazole.

Authors:  Vandna Sharma; Brian Shing; Lilian Hernandez-Alvarez; Anjan Debnath; Larissa M Podust
Journal:  Mol Pharmacol       Date:  2020-10-02       Impact factor: 4.436
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