Literature DB >> 2168150

Specific inhibitors of herpes simplex virus thymidine kinase diminish reactivation of latent virus from explanted murine ganglia.

D A Leib1, K L Ruffner, C Hildebrand, P A Schaffer, G E Wright, D M Coen.   

Abstract

Two specific inhibitors of herpes simplex virus thymidine kinase, N2-phenyl-2'-deoxyguanosine and N2-(m-trifluoromethylphenyl)guanine, were tested for their ability to inhibit the reactivation of virus from explant cultures of latently infected murine trigeminal ganglia. Both compounds significantly diminished the frequency of reactivation compared with that of untreated controls.

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Year:  1990        PMID： 2168150      PMCID： PMC171804          DOI： 10.1128/AAC.34.6.1285

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  17 in total

1.  MUTANT STRAINS OF HERPES SIMPLEX DEFICIENT IN THYMIDINE KINASE-INDUCING ACTIVITY.

Authors:  D R DUBBS; S KIT
Journal:  Virology       Date:  1964-04       Impact factor: 3.616

2.  Herpes simplex virus thymidine kinase expression in infection of the trigeminal ganglion.

Authors:  R B Tenser; M E Dunstan
Journal:  Virology       Date:  1979-12       Impact factor: 3.616

3.  Collaborative complementation study of temperature-sensitive mutants of herpes simplex virus types 1 and 2.

Authors:  P A Schaffer; V C Carter; M C Timbury
Journal:  J Virol       Date:  1978-09       Impact factor: 5.103

4.  Structure-activity relationships of N2-substituted guanines as inhibitors of HSV1 and HSV2 thymidine kinases.

Authors:  C Hildebrand; D Sandoli; F Focher; J Gambino; G Ciarrocchi; S Spadari; G Wright
Journal:  J Med Chem       Date:  1990-01       Impact factor: 7.446

5.  The role of herpes simplex virus type 1 thymidine kinase in pathogenesis.

Authors:  S Efstathiou; S Kemp; G Darby; A C Minson
Journal:  J Gen Virol       Date:  1989-04       Impact factor: 3.891

6.  The pathogenicity of thymidine kinase-deficient mutants of herpes simplex virus in mice.

Authors:  H J Field; P Wildy
Journal:  J Hyg (Lond)       Date:  1978-10

7.  Induction of both thymidine and deoxycytidine kinase activity by herpes viruses.

Authors:  A T Jamieson; G A Gentry; J H Subak-Sharpe
Journal:  J Gen Virol       Date:  1974-09       Impact factor: 3.891

8.  Thymidine kinase-negative herpes simplex virus mutants establish latency in mouse trigeminal ganglia but do not reactivate.

Authors:  D M Coen; M Kosz-Vnenchak; J G Jacobson; D A Leib; C L Bogard; P A Schaffer; K L Tyler; D M Knipe
Journal:  Proc Natl Acad Sci U S A       Date:  1989-06       Impact factor: 11.205

9.  A herpes simplex virus ribonucleotide reductase deletion mutant is defective for productive acute and reactivatable latent infections of mice and for replication in mouse cells.

Authors:  J G Jacobson; D A Leib; D J Goldstein; C L Bogard; P A Schaffer; S K Weller; D M Coen
Journal:  Virology       Date:  1989-11       Impact factor: 3.616

10.  Herpes simplex virus type 1 ICP27 is an essential regulatory protein.

Authors:  W R Sacks; C C Greene; D P Aschman; P A Schaffer
Journal:  J Virol       Date:  1985-09       Impact factor: 5.103
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  13 in total

1.  Comparison of herpes simplex virus reactivation in ganglia in vivo and in explants demonstrates quantitative and qualitative differences.

Authors:  N M Sawtell; R L Thompson
Journal:  J Virol       Date:  2004-07       Impact factor: 5.103

2.  Prodrugs of herpes simplex thymidine kinase inhibitors.

Authors:  Milka Yanachkova; Wei-Chu Xu; Sofya Dvoskin; Edward J Dix; Ivan B Yanachkov; Federico Focher; Lida Savi; M Dulfary Sanchez; Timothy P Foster; George E Wright
Journal:  Antivir Chem Chemother       Date:  2015-10-13

3.  Herpes simplex virus thymidine kinase and specific stages of latency in murine trigeminal ganglia.

Authors:  J G Jacobson; K L Ruffner; M Kosz-Vnenchak; C B Hwang; K K Wobbe; D M Knipe; D M Coen
Journal:  J Virol       Date:  1993-11       Impact factor: 5.103

4.  Uracil in OriS of herpes simplex 1 alters its specific recognition by origin binding protein (OBP): does virus induced uracil-DNA glycosylase play a key role in viral reactivation and replication?

Authors:  F Focher; A Verri; S Verzeletti; P Mazzarello; S Spadari
Journal:  Chromosoma       Date:  1992       Impact factor: 4.316

5.  Evidence for a novel regulatory pathway for herpes simplex virus gene expression in trigeminal ganglion neurons.

Authors:  M Kosz-Vnenchak; J Jacobson; D M Coen; D M Knipe
Journal:  J Virol       Date:  1993-09       Impact factor: 5.103

6.  Herpes simplex virus type 1 uracil-DNA glycosylase: isolation and selective inhibition by novel uracil derivatives.

Authors:  F Focher; A Verri; S Spadari; R Manservigi; J Gambino; G E Wright
Journal:  Biochem J       Date:  1993-06-15       Impact factor: 3.857

7.  Lack of stereospecificity of suid pseudorabies virus thymidine kinase.

Authors:  G Maga; A Verri; L Bonizzi; W Ponti; G Poli; A Garbesi; D Niccolai; S Spadari; F Focher
Journal:  Biochem J       Date:  1993-09-01       Impact factor: 3.857

8.  Assessment of a selective inhibitor of herpes simplex virus thymidine kinase (L-653,180) as therapy for experimental recurrent genital herpes.

Authors:  N Bourne; F J Bravo; W T Ashton; L C Meurer; R L Tolman; J D Karkas; L R Stanberry
Journal:  Antimicrob Agents Chemother       Date:  1992-09       Impact factor: 5.191

9.  Human thymidine kinase can functionally replace herpes simplex virus type 1 thymidine kinase for viral replication in mouse sensory ganglia and reactivation from latency upon explant.

Authors:  S H Chen; W J Cook; K L Grove; D M Coen
Journal:  J Virol       Date:  1998-08       Impact factor: 5.103

Review 10.  History and genomic sequence analysis of the herpes simplex virus 1 KOS and KOS1.1 sub-strains.

Authors:  Robert C Colgrove; Xueqiao Liu; Anthony Griffiths; Priya Raja; Neal A Deluca; Ruchi M Newman; Donald M Coen; David M Knipe
Journal:  Virology       Date:  2015-11-05       Impact factor: 3.616
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