UNLABELLED: Although the clinical applications of (18)F-FDG PET/CT and diffusion-weighted MRI (DWI) are similar to each other in head and neck cancer, the image acquisition methods in the 2 modalities are significantly different. (18)F-FDG PET/CT traces glucose metabolism, a nonspecific process essential for tumor growth. On the other hand, DWI provides information on Brownian motion of water molecules in tissues, which represents cellularity. The aim of our study was to investigate whether apparent diffusion coefficient (ADC) values at b = 1,000 (ADC(1,000)) and 2,000 (ADC(2,000)) s/mm(2) or whether the change (ADC(ratio)) of ADC values from b = 1,000 to 2,000 s/mm(2) has any significant correlation with the standardized uptake value (SUV) in patients with head and neck squamous cell carcinoma (HNSCC). METHODS: Our hospital's institutional review board approved this retrospective study. We included 47 patients (32 men and 15 women) with histopathologically proven HNSCC, who underwent both DWI (at both b = 1,000 s/mm(2) and b = 2,000 s/mm(2)) and (18)F-FDG PET/CT in the 2 wk before treatment. ADC(ratio) maps were generated using a pixel-by-pixel computation for which ADC(ratio) is (ADC(2,000)/ADC(1,000)) × 100. The mean ADC(1,000), ADC(2,000), and ADC(ratio) values were evaluated within a manually placed polygonal region of interest within the main tumor on every slice of the ADC(1,000), ADC(2,000), and ADC(ratio) maps, respectively. In addition, the maximal SUV (SUV(max)) and mean SUV (SUV(mean)) were measured for the entire tumor region of interest. Comparisons were made using Pearson correlation analysis, and partial correlation coefficients were derived. RESULTS: No significant correlation was found between the mean ADC(1,000) and SUV(mean) (r = -0.222, P = 0.1325) or the mean ADC(2,000) and SUV(mean) (r = -0.1214, P = 0.4163). However, the ADC(ratio) was significantly and positively correlated to both the SUV(mean) (r = 0.667, P < 0.001) and SUV(max) (r = 0.5855, P < 0.001). CONCLUSION: The ADC(ratio) and SUV were significantly correlated with each other in primary HNSCC patients, possibly because of a higher-cellularity region as a result of relatively increased tumor proliferation. Further studies are warranted to investigate the possible complementary role of DWI and PET/CT in various clinical settings, including staging and treatment response.
UNLABELLED: Although the clinical applications of (18)F-FDG PET/CT and diffusion-weighted MRI (DWI) are similar to each other in head and neck cancer, the image acquisition methods in the 2 modalities are significantly different. (18)F-FDG PET/CT traces glucose metabolism, a nonspecific process essential for tumor growth. On the other hand, DWI provides information on Brownian motion of water molecules in tissues, which represents cellularity. The aim of our study was to investigate whether apparent diffusion coefficient (ADC) values at b = 1,000 (ADC(1,000)) and 2,000 (ADC(2,000)) s/mm(2) or whether the change (ADC(ratio)) of ADC values from b = 1,000 to 2,000 s/mm(2) has any significant correlation with the standardized uptake value (SUV) in patients with head and neck squamous cell carcinoma (HNSCC). METHODS: Our hospital's institutional review board approved this retrospective study. We included 47 patients (32 men and 15 women) with histopathologically proven HNSCC, who underwent both DWI (at both b = 1,000 s/mm(2) and b = 2,000 s/mm(2)) and (18)F-FDG PET/CT in the 2 wk before treatment. ADC(ratio) maps were generated using a pixel-by-pixel computation for which ADC(ratio) is (ADC(2,000)/ADC(1,000)) × 100. The mean ADC(1,000), ADC(2,000), and ADC(ratio) values were evaluated within a manually placed polygonal region of interest within the main tumor on every slice of the ADC(1,000), ADC(2,000), and ADC(ratio) maps, respectively. In addition, the maximal SUV (SUV(max)) and mean SUV (SUV(mean)) were measured for the entire tumor region of interest. Comparisons were made using Pearson correlation analysis, and partial correlation coefficients were derived. RESULTS: No significant correlation was found between the mean ADC(1,000) and SUV(mean) (r = -0.222, P = 0.1325) or the mean ADC(2,000) and SUV(mean) (r = -0.1214, P = 0.4163). However, the ADC(ratio) was significantly and positively correlated to both the SUV(mean) (r = 0.667, P < 0.001) and SUV(max) (r = 0.5855, P < 0.001). CONCLUSION: The ADC(ratio) and SUV were significantly correlated with each other in primary HNSCC patients, possibly because of a higher-cellularity region as a result of relatively increased tumor proliferation. Further studies are warranted to investigate the possible complementary role of DWI and PET/CT in various clinical settings, including staging and treatment response.
Authors: Alexis Vrachimis; Lars Stegger; Christian Wenning; Benjamin Noto; Matthias Christian Burg; Julia Renate Konnert; Thomas Allkemper; Walter Heindel; Burkhard Riemann; Michael Schäfers; Matthias Weckesser Journal: Eur J Nucl Med Mol Imaging Date: 2016-04-08 Impact factor: 9.236
Authors: Marcelo A Queiroz; Martin Hüllner; Felix Kuhn; Gerhardt Huber; Christian Meerwein; Spyros Kollias; Gustav von Schulthess; Patrick Veit-Haibach Journal: Eur J Nucl Med Mol Imaging Date: 2014-08-05 Impact factor: 9.236
Authors: Lorenzo Preda; Giorgio Conte; Luke Bonello; Caterina Giannitto; Laura L Travaini; Sara Raimondi; Paul E Summers; Ansarin Mohssen; Daniela Alterio; Maria Cossu Rocca; Chiara Grana; Francesca Ruju; Massimo Bellomi Journal: Eur Radiol Date: 2016-03-10 Impact factor: 5.315
Authors: Kerstin Zwirner; Daniela Thorwarth; René M Winter; Stefan Welz; Jakob Weiss; Nina F Schwenzer; Holger Schmidt; Christian la Fougère; Konstantin Nikolaou; Daniel Zips; Sergios Gatidis Journal: Strahlenther Onkol Date: 2018-03-21 Impact factor: 3.621
Authors: Myo Min; Mark T Lee; Peter Lin; Lois Holloway; Dj Wijesekera; Dinesh Gooneratne; Robba Rai; Wei Xuan; Allan Fowler; Dion Forstner; Gary Liney Journal: Br J Radiol Date: 2015-12-09 Impact factor: 3.039