AIM: To investigate the diagnostic accuracy of hepatobiliary scintigraphy (HBS) in detecting biliary strictures in living donor liver transplantation (LDLT) patients. METHODS: We retrospectively reviewed 104 adult LDLT recipients of the right hepatic lobe with duct-to-duct anastomosis, who underwent HBS and cholangiography. The HBS results were categorized as normal, parenchymal dysfunction, biliary obstruction, or bile leakage without re-interpretation. The presence of biliary strictures was determined by percutaneous cholangiography or endoscopic retrograde cholangiopancreatography (ERCP). RESULTS: In 89 patients with biliary strictures, HBS showed biliary obstruction in 50 and no obstruction in 39, for a sensitivity of 56.2%. Of 15 patients with no biliary strictures, HBS showed no obstruction in 11, for a specificity of 73.3%. The positive predictive value (PPV) was 92.6% (50/54) and the negative predictive value (NPV) was 22% (11/50). We also analyzed the diagnostic accuracy of the change in bile duct size. The sensitivity, NPV, specificity, and PPV were 65.2%, 27.9%, 80% and 95%, respectively. CONCLUSION: The absence of biliary obstruction on HBS is not reliable. Thus, when post-LDLT biliary strictures are suspected, early ERCP may be considered.
AIM: To investigate the diagnostic accuracy of hepatobiliary scintigraphy (HBS) in detecting biliary strictures in living donor liver transplantation (LDLT) patients. METHODS: We retrospectively reviewed 104 adult LDLT recipients of the right hepatic lobe with duct-to-duct anastomosis, who underwent HBS and cholangiography. The HBS results were categorized as normal, parenchymal dysfunction, biliary obstruction, or bile leakage without re-interpretation. The presence of biliary strictures was determined by percutaneous cholangiography or endoscopic retrograde cholangiopancreatography (ERCP). RESULTS: In 89 patients with biliary strictures, HBS showed biliary obstruction in 50 and no obstruction in 39, for a sensitivity of 56.2%. Of 15 patients with no biliary strictures, HBS showed no obstruction in 11, for a specificity of 73.3%. The positive predictive value (PPV) was 92.6% (50/54) and the negative predictive value (NPV) was 22% (11/50). We also analyzed the diagnostic accuracy of the change in bile duct size. The sensitivity, NPV, specificity, and PPV were 65.2%, 27.9%, 80% and 95%, respectively. CONCLUSION: The absence of biliary obstruction on HBS is not reliable. Thus, when post-LDLT biliary strictures are suspected, early ERCP may be considered.
Authors: Jae Hyuck Chang; In Seok Lee; Jong Young Choi; Seung Kyoo Yoon; Dong Goo Kim; Young Kyoung You; Ho Jong Chun; Dong Ki Lee; Myung-Gyu Choi; In-Sik Chung Journal: Gut Liver Date: 2010-06-16 Impact factor: 4.519
Authors: M M Linhares; A M Gonzalez; S M Goldman; R D S Coelho; N Y Sato; R M A M Moura; M H G Silva; V P Lanzoni; A Salzedas; C B Serra; T Succi; G D'Ippolito; J Szejnfeld; T Triviño Journal: Transplant Proc Date: 2004-05 Impact factor: 1.066
Authors: M S Al Sofayan; A Ibrahim; A Helmy; M I Al Saghier; M I Al Sebayel; M M Abozied Journal: Transplant Proc Date: 2009 Jan-Feb Impact factor: 1.066
Authors: Eric J Monroe; David S Shin; Victoria A Young; Jeffrey Forris Beecham Chick; Kevin S H Koo; Andrew Woerner; Christopher R Ingraham Journal: Pediatr Radiol Date: 2021-10-29