Literature DB >> 21676426

Determinants of the HIV-1 core assembly pathway.

Claudia S López1, Jacob D Eccles, Amelia Still, Rachel E Sloan, Robin Lid Barklis, Seyram M Tsagli, Eric Barklis.   

Abstract

Based on structural information, we have analyzed the mechanism of mature HIV-1 core assembly and the contributions of structural elements to the assembly process. Through the use of several in vitro assembly assay systems, we have examined details of how capsid (CA) protein helix 1, ß-hairpin and cyclophilin loop elements impact assembly-dependent protein interactions, and we present evidence for a contribution of CA helix 6 to the mature assembly-competent conformation of CA. Additional experiments with mixtures of proteins in assembly reactions provide novel analyses of the mature core assembly mechanism. Our results support a model in which initial assembly products serve as scaffolds for further assembly by converting incoming subunits to assembly proficient conformations, while mutant subunits increase the probability of assembly termination events.
Copyright © 2011 Elsevier Inc. All rights reserved.

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Year:  2011        PMID： 21676426      PMCID： PMC3152690          DOI： 10.1016/j.virol.2011.05.011

Source DB:  PubMed          Journal:  Virology        ISSN： 0042-6822            Impact factor:   3.616


  64 in total

1.  Structures of the HIV-1 capsid protein dimerization domain at 2.6 A resolution.

Authors:  D K Worthylake; H Wang; S Yoo; W I Sundquist; C P Hill
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  1999-01-01

2.  Head-to-tail dimers and interdomain flexibility revealed by the crystal structure of HIV-1 capsid protein (p24) complexed with a monoclonal antibody Fab.

Authors:  C Berthet-Colominas; S Monaco; A Novelli; G Sibaï; F Mallet; S Cusack
Journal:  EMBO J       Date:  1999-03-01       Impact factor: 11.598

3.  The HIV-1 capsid protein C-terminal domain in complex with a virus assembly inhibitor.

Authors:  François Ternois; Jana Sticht; Stéphane Duquerroy; Hans-Georg Kräusslich; Félix A Rey
Journal:  Nat Struct Mol Biol       Date:  2005-07-24       Impact factor: 15.369

4.  Assembly of human immunodeficiency virus precursor gag proteins.

Authors:  Doug Huseby; Robin Lid Barklis; Ayna Alfadhli; Eric Barklis
Journal:  J Biol Chem       Date:  2005-02-25       Impact factor: 5.157

5.  Human immunodeficiency virus type 1 Gag polyprotein multimerization requires the nucleocapsid domain and RNA and is promoted by the capsid-dimer interface and the basic region of matrix protein.

Authors:  M T Burniston; A Cimarelli; J Colgan; S P Curtis; J Luban
Journal:  J Virol       Date:  1999-10       Impact factor: 5.103

6.  Identification of human immunodeficiency virus type 1 Gag protein domains essential to membrane binding and particle assembly.

Authors:  P Spearman; J J Wang; N Vander Heyden; L Ratner
Journal:  J Virol       Date:  1994-05       Impact factor: 5.103

7.  Mapping of functionally important residues of a cysteine-histidine box in the human immunodeficiency virus type 1 nucleocapsid protein.

Authors:  T Dorfman; J Luban; S P Goff; W A Haseltine; H G Göttlinger
Journal:  J Virol       Date:  1993-10       Impact factor: 5.103

8.  Identification of a membrane-binding domain within the amino-terminal region of human immunodeficiency virus type 1 Gag protein which interacts with acidic phospholipids.

Authors:  W Zhou; L J Parent; J W Wills; M D Resh
Journal:  J Virol       Date:  1994-04       Impact factor: 5.103

9.  The spacer peptide between human immunodeficiency virus capsid and nucleocapsid proteins is essential for ordered assembly and viral infectivity.

Authors:  H G Kräusslich; M Fäcke; A M Heuser; J Konvalinka; H Zentgraf
Journal:  J Virol       Date:  1995-06       Impact factor: 5.103

10.  A peptide inhibitor of HIV-1 assembly in vitro.

Authors:  Jana Sticht; Michael Humbert; Stuart Findlow; Jochen Bodem; Barbara Müller; Ursula Dietrich; Jörn Werner; Hans-Georg Kräusslich
Journal:  Nat Struct Mol Biol       Date:  2005-07-24       Impact factor: 15.369
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  13 in total

1.  Biophysical analysis of the MHR motif in folding and domain swapping of the HIV capsid protein C-terminal domain.

Authors:  Rebeca Bocanegra; Miguel Ángel Fuertes; Alicia Rodríguez-Huete; José Luis Neira; Mauricio G Mateu
Journal:  Biophys J       Date:  2015-01-20       Impact factor: 4.033

2.  Analysis of HIV-1 Matrix-Envelope Cytoplasmic Tail Interactions.

Authors:  Ayna Alfadhli; August O Staubus; Philip R Tedbury; Mariia Novikova; Eric O Freed; Eric Barklis
Journal:  J Virol       Date:  2019-10-15       Impact factor: 5.103

3.  Second site reversion of a mutation near the amino terminus of the HIV-1 capsid protein.

Authors:  Claudia S López; Seyram M Tsagli; Rachel Sloan; Jacob Eccles; Eric Barklis
Journal:  Virology       Date:  2013-09-21       Impact factor: 3.616

Review 4.  HIV-1 Capsid Inhibitors as Antiretroviral Agents.

Authors:  Suzie Thenin-Houssier; Susana T Valente
Journal:  Curr HIV Res       Date:  2016       Impact factor: 1.581

5.  Ebselen, a Small-Molecule Capsid Inhibitor of HIV-1 Replication.

Authors:  Suzie Thenin-Houssier; Ian Mitchelle S de Vera; Laura Pedro-Rosa; Angela Brady; Audrey Richard; Briana Konnick; Silvana Opp; Cindy Buffone; Jakob Fuhrmann; Smitha Kota; Blase Billack; Magdalena Pietka-Ottlik; Timothy Tellinghuisen; Hyeryun Choe; Timothy Spicer; Louis Scampavia; Felipe Diaz-Griffero; Douglas J Kojetin; Susana T Valente
Journal:  Antimicrob Agents Chemother       Date:  2016-03-25       Impact factor: 5.191

6.  Dynamic regulation of HIV-1 capsid interaction with the restriction factor TRIM5α identified by magic-angle spinning NMR and molecular dynamics simulations.

Authors:  Caitlin M Quinn; Mingzhang Wang; Matthew P Fritz; Brent Runge; Jinwoo Ahn; Chaoyi Xu; Juan R Perilla; Angela M Gronenborn; Tatyana Polenova
Journal:  Proc Natl Acad Sci U S A       Date:  2018-10-17       Impact factor: 11.205

Review 7.  Integrative structural biology of HIV-1 capsid protein assemblies: combining experiment and computation.

Authors:  Juan R Perilla; Jodi A Hadden-Perilla; Angela M Gronenborn; Tatyana Polenova
Journal:  Curr Opin Virol       Date:  2021-04-23       Impact factor: 7.121

8.  In vitro assembly of the Rous Sarcoma Virus capsid protein into hexamer tubes at physiological temperature.

Authors:  Soumeya A Jaballah; Graham D Bailey; Ambroise Desfosses; Jaekyung Hyun; Alok K Mitra; Richard L Kingston
Journal:  Sci Rep       Date:  2017-06-06       Impact factor: 4.379

9.  The maturational refolding of the β-hairpin motif of equine infectious anemia virus capsid protein extends its helix α1 at capsid assembly locus.

Authors:  Kang Chen; Grzegorz Piszczek; Carol Carter; Nico Tjandra
Journal:  J Biol Chem       Date:  2012-11-26       Impact factor: 5.157

10.  Discovery of novel 1,4-disubstituted 1,2,3-triazole phenylalanine derivatives as HIV-1 capsid inhibitors.

Authors:  Xiangyi Jiang; Gaochan Wu; Waleed A Zalloum; Megan E Meuser; Alexej Dick; Lin Sun; Chin-Ho Chen; Dongwei Kang; Lanlan Jing; Ruifang Jia; Simon Cocklin; Kuo-Hsiung Lee; Xinyong Liu; Peng Zhan
Journal:  RSC Adv       Date:  2019-09-16       Impact factor: 4.036
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