BACKGROUND AND OBJECTIVES: The purpose of this study was to investigate the role of the standardized uptake values (SUV), a semi-quantitative assessment of tumor FDG uptake, as a prognosticator for advanced signet ring cell carcinoma (SRC). METHODS: We reviewed the files of 41 patients who underwent curative gastrectomy for advanced SRC and who had an FDG-PET at initial presentation between September 2003 and December 2007. RESULTS: The median follow-up period was 30.9 months (range: 4.0-70.3). We found a correlation between the SUVmax and TNM stage. When the patients were divided into two groups (low vs. high SUVmax) based on a median SUVmax of 3.80, the high-SUVmax group showed more aggressive tumor behavior than did the low SUVmax group. In addition, the high SUVmax group showed more postoperative recurrence (P = 0.028), shorter relapse-free survival (P = 0.004), and lower 30-month cancer-specific survival rates (40.0% vs. 69.3%, P = 0.008). However, in multivariate analysis, SUVmax failed to be an independent predictor of overall survival. CONCLUSIONS: Although SUVmax of initial PET scan was not an independent predictor of patient outcomes after curative surgery, higher SUVmax is associated with more advanced stage and indicates more aggressive tumor biology in advanced SRC.
BACKGROUND AND OBJECTIVES: The purpose of this study was to investigate the role of the standardized uptake values (SUV), a semi-quantitative assessment of tumorFDG uptake, as a prognosticator for advanced signet ring cell carcinoma (SRC). METHODS: We reviewed the files of 41 patients who underwent curative gastrectomy for advanced SRC and who had an FDG-PET at initial presentation between September 2003 and December 2007. RESULTS: The median follow-up period was 30.9 months (range: 4.0-70.3). We found a correlation between the SUVmax and TNM stage. When the patients were divided into two groups (low vs. high SUVmax) based on a median SUVmax of 3.80, the high-SUVmax group showed more aggressive tumor behavior than did the low SUVmax group. In addition, the high SUVmax group showed more postoperative recurrence (P = 0.028), shorter relapse-free survival (P = 0.004), and lower 30-month cancer-specific survival rates (40.0% vs. 69.3%, P = 0.008). However, in multivariate analysis, SUVmax failed to be an independent predictor of overall survival. CONCLUSIONS: Although SUVmax of initial PET scan was not an independent predictor of patient outcomes after curative surgery, higher SUVmax is associated with more advanced stage and indicates more aggressive tumor biology in advanced SRC.
Authors: Nikolaos Charalampakis; Lianchun Xiao; Elena Elimova; Roopma Wadhwa; Hironori Shiozaki; Yusuke Shimodaira; Mariela A Blum; Venkatram Planjery; Jane E Rogers; Aurelio Matamoros; Tara Sagebiel; Prajnan Das; Jeffrey H Lee; Manoop S Bhutani; Brian Weston; Jeannelyn S Estrella; Brian D Badgwell; Jaffer A Ajani Journal: Oncology Date: 2015-09-23 Impact factor: 2.935
Authors: Ji Soo Park; Nare Lee; Seung Hoon Beom; Hyo Song Kim; Choong-Kun Lee; Sun Young Rha; Hyun Cheol Chung; Mijin Yun; Arthur Cho; Minkyu Jung Journal: Gastric Cancer Date: 2017-06-22 Impact factor: 7.370
Authors: Jae Yun Lim; Sun Och Yoon; So Young Seol; Soon Won Hong; Jong Won Kim; Seung Ho Choi; Jae Yong Cho Journal: World J Gastroenterol Date: 2012-08-14 Impact factor: 5.742
Authors: Kazuto Harada; Madhavi Patnana; Xuemei Wang; Masaaki Iwatsuki; Mariela A Blum Murphy; Meina Zhao; Prajnan Das; Bruce D Minsky; Brian Weston; Jeffrey H Lee; Manoop S Bhutani; Jeannelyn S Estrella; Namita Shanbhag; Naruhiko Ikoma; Brian D Badgwell; Jaffer A Ajani Journal: Surg Today Date: 2020-05-14 Impact factor: 2.540