Literature DB >> 26877609

Glucose metabolism in gastric cancer: The cutting-edge.

Lian-Wen Yuan1, Hiroharu Yamashita1, Yasuyuki Seto1.   

Abstract

Glucose metabolism in gastric cancer cells differs from that of normal epithelial cells. Upregulated aerobic glycolysis (Warburg effect) in gastric cancer meeting the demands of cell proliferation is associated with genetic mutations, epigenetic modification and proteomic alteration. Understanding the mechanisms of aerobic glycolysis may contribute to our knowledge of gastric carcinogenesis. Metabolomic studies offer novel, convenient and practical tools in the search for new biomarkers for early detection, diagnosis, prognosis, and chemosensitivity prediction of gastric cancer. Interfering with the process of glycolysis in cancer cells may provide a new and promising therapeutic strategy for gastric cancer. In this article, we present a brief review of recent studies of glucose metabolism in gastric cancer, with primary focus on the clinical applications of new biomarkers and their potential therapeutic role in gastric cancer.

Entities:  

Keywords:  Biomarker; Gastric cancer; Glucose metabolism; Metabolomics; Therapy; Warburg effect

Mesh：

Substances：

Year:  2016        PMID： 26877609      PMCID： PMC4726677          DOI： 10.3748/wjg.v22.i6.2046

Source DB:  PubMed          Journal:  World J Gastroenterol        ISSN： 1007-9327            Impact factor:   5.742


  139 in total

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4.  Quantitative two-dimensional HRMAS 1H-NMR spectroscopy-based metabolite profiling of human cancer cell lines and response to chemotherapy.

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7.  Urinary metabonomic study on colorectal cancer.

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Journal:  Neoplasma       Date:  1987       Impact factor: 2.575

9.  18F-FDG uptake in primary gastric malignant lymphoma correlates with glucose transporter 1 expression and histologic malignant potential.

Authors:  Yuko Watanabe; Hiroaki Suefuji; Yasumitsu Hirose; Hayato Kaida; Gen Suzuki; Jun Uozumi; Etsuyo Ogo; Mayumi Miura; Konomi Takasu; Kanoko Miyazaki; Keita Nakahara; Masatoshi Ishibashi; Takashi Okamura; Koichi Ohshima; Naofumi Hayabuchi
Journal:  Int J Hematol       Date:  2012-12-02       Impact factor: 2.490

10.  The influence of changes in tumor hypoxia on dose-painting treatment plans based on 18F-FMISO positron emission tomography.

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  35 in total

1.  Sulfite Oxidase Is a Novel Prognostic Biomarker of Advanced Gastric Cancer.

Authors:  Yuta Yano; Jun Akiba; Yoshiki Naito; Eiji Sadashima; Haruhiko Cho; Tsunekazu Hishima; Hirohisa Yano
Journal:  In Vivo       Date:  2021 Jan-Feb       Impact factor: 2.155

2.  Helicobacter pylori infection promotes Aquaporin 3 expression via the ROS-HIF-1α-AQP3-ROS loop in stomach mucosa: a potential novel mechanism for cancer pathogenesis.

Authors:  Jianfei Wen; Yao Wang; Cheng Gao; Guoxin Zhang; Qiang You; Weiming Zhang; Zhihong Zhang; Shoulin Wang; Guangyong Peng; Lizong Shen
Journal:  Oncogene       Date:  2018-03-22       Impact factor: 9.867

3.  Metabolomics of Gastric Cancer.

Authors:  Wroocha Kadam; Bowen Wei; Feng Li
Journal:  Adv Exp Med Biol       Date:  2021       Impact factor: 2.622

4.  A novel metabolism-related prognostic gene development and validation in gastric cancer.

Authors:  Xingxing Zhang; Xu Chen; Jiayun Liu; Yaqi Li; Jian Wu; Menglin Chen; Ruijuan Zhang; Xintian Xu; Tianyi Xu; Qingmin Sun
Journal:  Clin Transl Oncol       Date:  2022-09-27       Impact factor: 3.340

Review 5.  Gastric cancer: a comprehensive review of current and future treatment strategies.

Authors:  Rachel E Sexton; Mohammed Najeeb Al Hallak; Maria Diab; Asfar S Azmi
Journal:  Cancer Metastasis Rev       Date:  2020-09-07       Impact factor: 9.264

6.  DLX6 Antisense RNA 1 Modulates Glucose Metabolism and Cell Growth in Gastric Cancer by Targeting microRNA-4290.

Authors:  Yan Qian; Wei Song; Xu Wu; Guowei Hou; Haixiao Wang; Xiao Hang; Tianfang Xia
Journal:  Dig Dis Sci       Date:  2020-04-01       Impact factor: 3.199

Review 7.  Impacts and mechanisms of metabolic reprogramming of tumor microenvironment for immunotherapy in gastric cancer.

Authors:  Lin Zhao; Yuanyuan Liu; Simiao Zhang; Lingyu Wei; Hongbing Cheng; Jinsheng Wang; Jia Wang
Journal:  Cell Death Dis       Date:  2022-04-20       Impact factor: 9.685

Review 8.  Dietary phytochemicals and cancer chemoprevention: a review of the clinical evidence.

Authors:  Ritesh Kotecha; Akiyoshi Takami; J Luis Espinoza
Journal:  Oncotarget       Date:  2016-08-09

9.  Overexpression of MPC1 inhibits the proliferation, migration, invasion, and stem cell-like properties of gastric cancer cells.

Authors:  Xiang Zhou; Zhu-Juan Xiong; Shuo-Meng Xiao; Jin Zhou; Zhi Ding; Ling-Chao Tang; Xiao-Dong Chen; Rui Xu; Ping Zhao
Journal:  Onco Targets Ther       Date:  2017-10-24       Impact factor: 4.147

Review 10.  Gastric Cancer Stem Cells: A Glimpse on Metabolic Reprogramming.

Authors:  Martina Addeo; Giuseppina Di Paola; Henu Kumar Verma; Simona Laurino; Sabino Russi; Pietro Zoppoli; Geppino Falco; Pellegrino Mazzone
Journal:  Front Oncol       Date:  2021-06-16       Impact factor: 6.244
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