Literature DB >> 21670513

Characterization of 2-octenoyl-CoA carboxylase/reductase utilizing pteB from Streptomyce avermitilis.

Hye-Gyeong Yoo1, So-Yeon Kwon, Suji Kim, Suman Karki, Zee-Yong Park, Hyung-Jin Kwon.   

Abstract

The filipin biosynthetic gene cluster of Streptomyces avermitilis contains pteB, a homolog of crotonyl-CoA carboxylase/reductase. PteB was predicted to be 2-octenoyl-CoA carboxylase/reductase, supplying hexylmalonyl-CoA to filipin biosynthesis. Recombinant PteB displayed selective reductase activity toward 2-octenoyl-CoA while generating a broad range of alkylmalonyl-CoAs in the presence of bicarbonate.

Entities:  

Mesh：

Substances：

Year:  2011        PMID： 21670513     DOI： 10.1271/bbb.110003

Source DB:  PubMed          Journal:  Biosci Biotechnol Biochem        ISSN： 0916-8451            Impact factor:   2.043


  9 in total

Review 1.  Carboxylases in natural and synthetic microbial pathways.

Authors:  Tobias J Erb
Journal:  Appl Environ Microbiol       Date:  2011-10-14       Impact factor: 4.792

2.  Engineering the Substrate Specificity of a Modular Polyketide Synthase for Installation of Consecutive Non-Natural Extender Units.

Authors:  Edward Kalkreuter; Jared M CroweTipton; Andrew N Lowell; David H Sherman; Gavin J Williams
Journal:  J Am Chem Soc       Date:  2019-01-24       Impact factor: 15.419

3.  Unusual carbon fixation gives rise to diverse polyketide extender units.

Authors:  Nick Quade; Liujie Huo; Shwan Rachid; Dirk W Heinz; Rolf Müller
Journal:  Nat Chem Biol       Date:  2011-12-04       Impact factor: 15.040

Review 4.  Recent advances in the biosynthesis of unusual polyketide synthase substrates.

Authors:  Lauren Ray; Bradley S Moore
Journal:  Nat Prod Rep       Date:  2016-02       Impact factor: 13.423

5.  Direct evidence for a covalent ene adduct intermediate in NAD(P)H-dependent enzymes.

Authors:  Raoul G Rosenthal; Marc-Olivier Ebert; Patrick Kiefer; Dominik M Peter; Julia A Vorholt; Tobias J Erb
Journal:  Nat Chem Biol       Date:  2013-11-17       Impact factor: 15.040

6.  Roles of the crotonyl-CoA carboxylase/reductase homologues in acetate assimilation and biosynthesis of immunosuppressant FK506 in Streptomyces tsukubaensis.

Authors:  Marko Blažič; Gregor Kosec; Špela Baebler; Kristina Gruden; Hrvoje Petković
Journal:  Microb Cell Fact       Date:  2015-10-14       Impact factor: 5.328

7.  A crotonyl-CoA reductase-carboxylase independent pathway for assembly of unusual alkylmalonyl-CoA polyketide synthase extender units.

Authors:  Lauren Ray; Timothy R Valentic; Takeshi Miyazawa; David M Withall; Lijiang Song; Jacob C Milligan; Hiroyuki Osada; Shunji Takahashi; Shiou-Chuan Tsai; Gregory L Challis
Journal:  Nat Commun       Date:  2016-12-21       Impact factor: 14.919

8.  Phosphate effect on filipin production and morphological differentiation in Streptomyces filipinensis and the role of the PhoP transcription factor.

Authors:  Eva G Barreales; Tamara D Payero; Antonio de Pedro; Jesús F Aparicio
Journal:  PLoS One       Date:  2018-12-06       Impact factor: 3.240

9.  Functional analysis of filipin tailoring genes from Streptomyces filipinensis reveals alternative routes in filipin III biosynthesis and yields bioactive derivatives.

Authors:  Tamara D Payero; Cláudia M Vicente; Ángel Rumbero; Eva G Barreales; Javier Santos-Aberturas; Antonio de Pedro; Jesús F Aparicio
Journal:  Microb Cell Fact       Date:  2015-08-07       Impact factor: 5.328
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.