Literature DB >> 2167040

In vitro inhibition of bacterial DNA gyrase by cinodine, a glycocinnamoylspermidine antibiotic.

M S Osburne1, W M Maiese, M Greenstein.   

Abstract

Cinodine, a broad-spectrum glycocinnamoylspermidine antibiotic, binds to DNA and irreversibly inhibits bacterial and phase DNA synthesis. Cinodine was found to inhibit the activity of Micrococcus luteus DNA gyrase in vitro, but it did not inhibit the activities of two other DNA-binding enzymes, namely, topoisomerase I and BamHI. Although we cannot yet conclude that DNA gyrase is an intracellular target of the drug, in vitro inhibition of the enzyme by cinodine appears to be specific.

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Year:  1990        PMID： 2167040      PMCID： PMC176000          DOI： 10.1128/AAC.34.7.1450

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  12 in total

1.  Mechanism of action of nalidixic acid: purification of Escherichia coli nalA gene product and its relationship to DNA gyrase and a novel nicking-closing enzyme.

Authors:  A Sugino; C L Peebles; K N Kreuzer; N R Cozzarelli
Journal:  Proc Natl Acad Sci U S A       Date:  1977-11       Impact factor: 11.205

2.  Energy coupling in DNA gyrase and the mechanism of action of novobiocin.

Authors:  A Sugino; N P Higgins; P O Brown; C L Peebles; N R Cozzarelli
Journal:  Proc Natl Acad Sci U S A       Date:  1978-10       Impact factor: 11.205

Review 3.  Inhibitors of DNA topoisomerases.

Authors:  K Drlica; R J Franco
Journal:  Biochemistry       Date:  1988-04-05       Impact factor: 3.162

4.  Novobiocin and coumermycin inhibit DNA supercoiling catalyzed by DNA gyrase.

Authors:  M Gellert; M H O'Dea; T Itoh; J Tomizawa
Journal:  Proc Natl Acad Sci U S A       Date:  1976-12       Impact factor: 11.205

Review 5.  DNA topoisomerases.

Authors:  M Gellert
Journal:  Annu Rev Biochem       Date:  1981       Impact factor: 23.643

6.  Escherichia coli DNA gyrase.

Authors:  R Otter; N R Cozzarelli
Journal:  Methods Enzymol       Date:  1983       Impact factor: 1.600

7.  Glycocinnamoylspermidines, a new class of antibiotics. II. Isolation, physiocochemical and biological properties of LL-BM123beta, gamma1 and gamma2.

Authors:  J H Martin; M P Kunstmann; F Barbatschi; M Hertz; G A Ellestad; M Dann; G S Redin; A C Dornbush; N A Kuck
Journal:  J Antibiot (Tokyo)       Date:  1978-05       Impact factor: 2.649

Review 8.  DNA gyrase and the supercoiling of DNA.

Authors:  N R Cozzarelli
Journal:  Science       Date:  1980-02-29       Impact factor: 47.728

9.  Nalidixic acid resistance: a second genetic character involved in DNA gyrase activity.

Authors:  M Gellert; K Mizuuchi; M H O'Dea; T Itoh; J I Tomizawa
Journal:  Proc Natl Acad Sci U S A       Date:  1977-11       Impact factor: 11.205

10.  Mechanism of action of cinodine, a glycocinnamoylspermidine antibiotic.

Authors:  M Greenstein; J L Speth; W M Maiese
Journal:  Antimicrob Agents Chemother       Date:  1981-10       Impact factor: 5.191
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  6 in total

1.  Mode of action of GR122222X, a novel inhibitor of bacterial DNA gyrase.

Authors:  M Oram; B Dosanjh; N A Gormley; C V Smith; L M Fisher; A Maxwell; K Duncan
Journal:  Antimicrob Agents Chemother       Date:  1996-02       Impact factor: 5.191

2.  Investigations of scope and mechanism of nickel-catalyzed transformations of glycosyl trichloroacetimidates to glycosyl trichloroacetamides and subsequent, atom-economical, one-step conversion to α-urea-glycosides.

Authors:  Matthew J McKay; Nathaniel H Park; Hien M Nguyen
Journal:  Chemistry       Date:  2014-06-06       Impact factor: 5.236

3.  Detection of tetracyclines and efflux pump inhibitors.

Authors:  D M Rothstein; M McGlynn; V Bernan; J McGahren; J Zaccardi; N Cekleniak; K P Bertrand
Journal:  Antimicrob Agents Chemother       Date:  1993-08       Impact factor: 5.191

4.  Mechanism of inhibition of DNA gyrase by cyclothialidine, a novel DNA gyrase inhibitor.

Authors:  N Nakada; H Gmünder; T Hirata; M Arisawa
Journal:  Antimicrob Agents Chemother       Date:  1994-09       Impact factor: 5.191

5.  Cloning and nucleotide sequence of Pseudomonas aeruginosa DNA gyrase gyrA gene from strain PAO1 and quinolone-resistant clinical isolates.

Authors:  A Kureishi; J M Diver; B Beckthold; T Schollaardt; L E Bryan
Journal:  Antimicrob Agents Chemother       Date:  1994-09       Impact factor: 5.191

Review 6.  Exploiting bacterial DNA gyrase as a drug target: current state and perspectives.

Authors:  Frédéric Collin; Shantanu Karkare; Anthony Maxwell
Journal:  Appl Microbiol Biotechnol       Date:  2011-09-09       Impact factor: 4.813
  6 in total

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