Literature DB >> 8834902

Mode of action of GR122222X, a novel inhibitor of bacterial DNA gyrase.

M Oram1, B Dosanjh, N A Gormley, C V Smith, L M Fisher, A Maxwell, K Duncan.   

Abstract

GR122222X is a potent inhibitor of the supercoiling reaction of bacterial DNA gyrase. We show that this compound binds stoichiometrically to inactivate the ATPase activity of a 43-kDa N-terminal fragment of the B subunit and competitively inhibits the binding of a radiolabelled coumarin drug to N-terminal fragments of GyrB. These and other data suggest that GR122222X has a mode of action similar, but not identical, to that of coumarin antibiotics.

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Year:  1996        PMID： 8834902      PMCID： PMC163138     

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  27 in total

1.  gyrB mutations which confer coumarin resistance also affect DNA supercoiling and ATP hydrolysis by Escherichia coli DNA gyrase.

Authors:  A Contreras; A Maxwell
Journal:  Mol Microbiol       Date:  1992-06       Impact factor: 3.501

Review 2.  The molecular basis of quinolone action.

Authors:  A Maxwell
Journal:  J Antimicrob Chemother       Date:  1992-10       Impact factor: 5.790

Review 3.  Inhibitors of DNA gyrase.

Authors:  K Drlica; S Coughlin
Journal:  Pharmacol Ther       Date:  1989       Impact factor: 12.310

4.  Clerocidin, a terpenoid antibiotic, inhibits bacterial DNA gyrase.

Authors:  J E McCullough; M T Muller; A J Howells; A Maxwell; J O'Sullivan; R S Summerill; W L Parker; J S Wells; D P Bonner; P B Fernandes
Journal:  J Antibiot (Tokyo)       Date:  1993-03       Impact factor: 2.649

5.  The 43-kilodalton N-terminal fragment of the DNA gyrase B protein hydrolyzes ATP and binds coumarin drugs.

Authors:  J A Ali; A P Jackson; A J Howells; A Maxwell
Journal:  Biochemistry       Date:  1993-03-16       Impact factor: 3.162

Review 6.  The interaction between coumarin drugs and DNA gyrase.

Authors:  A Maxwell
Journal:  Mol Microbiol       Date:  1993-08       Impact factor: 3.501

7.  Crystallization of inhibitor complexes of an N-terminal 24 kDa fragment of the DNA gyrase B protein.

Authors:  R J Lewis; O M Singh; C V Smith; A Maxwell; T Skarzynski; A J Wonacott; D B Wigley
Journal:  J Mol Biol       Date:  1994-08-05       Impact factor: 5.469

8.  The 24 kDa N-terminal sub-domain of the DNA gyrase B protein binds coumarin drugs.

Authors:  E J Gilbert; A Maxwell
Journal:  Mol Microbiol       Date:  1994-05       Impact factor: 3.501

9.  Biological characterization of cyclothialidine, a new DNA gyrase inhibitor.

Authors:  N Nakada; H Shimada; T Hirata; Y Aoki; T Kamiyama; J Watanabe; M Arisawa
Journal:  Antimicrob Agents Chemother       Date:  1993-12       Impact factor: 5.191

Review 10.  Cyclothialidine and its congeners: a new class of DNA gyrase inhibitors.

Authors:  E Goetschi; P Angehrn; H Gmuender; P Hebeisen; H Link; R Masciadri; J Nielsen
Journal:  Pharmacol Ther       Date:  1993-11       Impact factor: 12.310
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  2 in total

1.  Gene expression changes triggered by exposure of Haemophilus influenzae to novobiocin or ciprofloxacin: combined transcription and translation analysis.

Authors:  H Gmuender; K Kuratli; C P Gray; W Keck; S Evers
Journal:  Genome Res       Date:  2001-01       Impact factor: 9.043

Review 2.  Exploiting bacterial DNA gyrase as a drug target: current state and perspectives.

Authors:  Frédéric Collin; Shantanu Karkare; Anthony Maxwell
Journal:  Appl Microbiol Biotechnol       Date:  2011-09-09       Impact factor: 4.813
  2 in total

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