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Literature DB >> 21670165

The regulation and physiology of mitochondrial proton leak.

Abstract

Mitochondria couple respiration to ATP synthesis through an electrochemical proton gradient. Proton leak across the inner membrane allows adjustment of the coupling efficiency. The aim of this review is threefold: 1) introduce the unfamiliar reader to proton leak and its physiological significance, 2) review the role and regulation of uncoupling proteins, and 3) outline the prospects of proton leak as an avenue to treat obesity, diabetes, and age-related disease.

Entities: Chemical Disease

Mesh：

Substances：

Year: 2011 PMID： 21670165 DOI： 10.1152/physiol.00046.2010

Source DB: PubMed Journal: Physiology (Bethesda) ISSN： 1548-9221

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Cited

157 in total

Review 1. Mitochondrial membrane potential.

Authors: Ljubava D Zorova; Vasily A Popkov; Egor Y Plotnikov; Denis N Silachev; Irina B Pevzner; Stanislovas S Jankauskas; Valentina A Babenko; Savva D Zorov; Anastasia V Balakireva; Magdalena Juhaszova; Steven J Sollott; Dmitry B Zorov
Journal: Anal Biochem Date: 2017-07-12 Impact factor: 3.365

Review 2. Physiological and pathological roles of mitochondrial SLC25 carriers.

Authors: Manuel Gutiérrez-Aguilar; Christopher P Baines
Journal: Biochem J Date: 2013-09-15 Impact factor: 3.857

3. The growth factor receptor ERBB2 regulates mitochondrial activity on a signaling time scale.

Authors: Nirav Patel; Antoni Barrientos; Ralf Landgraf
Journal: J Biol Chem Date: 2013-10-18 Impact factor: 5.157

4. UCP2 overexpression worsens mitochondrial dysfunction and accelerates disease progression in a mouse model of amyotrophic lateral sclerosis.

Authors: Pablo M Peixoto; Hyun-Jeong Kim; Brittany Sider; Anatoly Starkov; Tamas L Horvath; Giovanni Manfredi
Journal: Mol Cell Neurosci Date: 2013-10-17 Impact factor: 4.314

5. Pyruvate dehydrogenase complex and nicotinamide nucleotide transhydrogenase constitute an energy-consuming redox circuit.

Authors: Kelsey H Fisher-Wellman; Chien-Te Lin; Terence E Ryan; Lauren R Reese; Laura A A Gilliam; Brook L Cathey; Daniel S Lark; Cody D Smith; Deborah M Muoio; P Darrell Neufer
Journal: Biochem J Date: 2015-04-15 Impact factor: 3.857

6. A switch in the source of ATP production and a loss in capacity to perform glycolysis are hallmarks of hepatocyte failure in advance liver disease.

Authors: Taichiro Nishikawa; Nadège Bellance; Aaron Damm; Han Bing; Zhen Zhu; Kan Handa; Mladen I Yovchev; Vasudha Sehgal; Tyler J Moss; Michael Oertel; Prahlad T Ram; Iraklis I Pipinos; Alejandro Soto-Gutierrez; Ira J Fox; Deepak Nagrath
Journal: J Hepatol Date: 2014-02-26 Impact factor: 25.083

The regulation and physiology of mitochondrial proton leak.

Review 1. Mitochondrial membrane potential.

Review 2. Physiological and pathological roles of mitochondrial SLC25 carriers.

3. The growth factor receptor ERBB2 regulates mitochondrial activity on a signaling time scale.

4. UCP2 overexpression worsens mitochondrial dysfunction and accelerates disease progression in a mouse model of amyotrophic lateral sclerosis.

5. Pyruvate dehydrogenase complex and nicotinamide nucleotide transhydrogenase constitute an energy-consuming redox circuit.

6. A switch in the source of ATP production and a loss in capacity to perform glycolysis are hallmarks of hepatocyte failure in advance liver disease.

Review 7. Integration of cellular bioenergetics with mitochondrial quality control and autophagy.

8. Reduced hepatic mitochondrial respiration following acute high-fat diet is prevented by PGC-1α overexpression.

9. Preliminary observations of mitochondrial dysfunction in Prader-Willi syndrome.

10. Mechanism of fatty-acid-dependent UCP1 uncoupling in brown fat mitochondria.