Literature DB >> 21665987

Effect of a combined treatment with growth hormone and melatonin in the cardiological aging on male SAMP8 mice.

Katherine Forman1, Elena Vara, Cruz García, Roman Kireev, Sara Cuesta, Germaine Escames, J A F Tresguerres.   

Abstract

The effect of a chronic combined treatment with growth hormone (GH) plus melatonin (Mel) on different age-related processes in cytosolic and nuclear fractions of hearts from SAMP8 mice (2 and 10 months) has been investigated. The parameters studied have been messenger RNA expressions of IL-1, IL-10, NFkBp50, NFkBp52, TNFα, eNOS, iNOS, HO-1, HO-2, BAD, BAX, and Bcl2 and protein expressions of iNOS, eNOS, TNFα, IL-1, IL-10, NFkBp50, NFKbp52, and caspase activity (3 and 9). Our results supported the existence of a proapoptotic and oxidative status together with inflammatory processes in the heart of old mice, with increases of inflammatory cytokines, caspase activity, HO-1, BAX, NFkBp50, and NFkBp52 and decreases of eNOS and Bcl2. Also, we were able to observe the translocation of NFkB to nuclei. The combined treatment was able to partially reduce the incidence of these deleterious changes, showing differences with the separated treatments with GH and Mel as were investigated in previous articles from our group.

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Year:  2011        PMID： 21665987     DOI： 10.1093/gerona/glr083

Source DB:  PubMed          Journal:  J Gerontol A Biol Sci Med Sci        ISSN： 1079-5006            Impact factor:   6.053


  22 in total

1.  Disruption of Nrf2 signaling impairs angiogenic capacity of endothelial cells: implications for microvascular aging.

Authors:  M Noa Valcarcel-Ares; Tripti Gautam; Junie P Warrington; Lora Bailey-Downs; Danuta Sosnowska; Rafael de Cabo; Gyorgy Losonczy; William E Sonntag; Zoltan Ungvari; Anna Csiszar
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2012-01-04       Impact factor: 6.053

2.  Effect of long-term treatment with melatonin on vascular markers of oxidative stress/inflammation and on the anticontractile activity of perivascular fat in aging mice.

Authors:  Claudia Agabiti-Rosei; Gaia Favero; Carolina De Ciuceis; Claudia Rossini; Enzo Porteri; Luigi Fabrizio Rodella; Lorenzo Franceschetti; Anna Maria Sarkar; Enrico Agabiti-Rosei; Damiano Rizzoni; Rita Rezzani
Journal:  Hypertens Res       Date:  2016-08-18       Impact factor: 3.872

Review 3.  Melatonin, mitochondria, and the metabolic syndrome.

Authors:  Daniel P Cardinali; Daniel E Vigo
Journal:  Cell Mol Life Sci       Date:  2017-08-17       Impact factor: 9.261

4.  Aging-induced dysregulation of dicer1-dependent microRNA expression impairs angiogenic capacity of rat cerebromicrovascular endothelial cells.

Authors:  Zoltan Ungvari; Zsuzsanna Tucsek; Danuta Sosnowska; Peter Toth; Tripti Gautam; Andrej Podlutsky; Agnes Csiszar; Gyorgy Losonczy; M Noa Valcarcel-Ares; William E Sonntag; Anna Csiszar
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2012-12-13       Impact factor: 6.053

Review 5.  Interleukin 4: Its Role in Hypertension, Atherosclerosis, Valvular, and Nonvalvular Cardiovascular Diseases.

Authors:  Kamal M Kassem; Mahboob Ali; Nour-Eddine Rhaleb
Journal:  J Cardiovasc Pharmacol Ther       Date:  2019-08-11       Impact factor: 2.457

6.  Growth hormone and IGF-1 deficiency exacerbate high-fat diet-induced endothelial impairment in obese Lewis dwarf rats: implications for vascular aging.

Authors:  Lora C Bailey-Downs; Danuta Sosnowska; Peter Toth; Matthew Mitschelen; Tripti Gautam; Jim C Henthorn; Praveen Ballabh; Akos Koller; Julie A Farley; William E Sonntag; Anna Csiszar; Zoltan Ungvari
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2011-11-10       Impact factor: 6.053

Review 7.  The emerging role of IGF-1 deficiency in cardiovascular aging: recent advances.

Authors:  Zoltan Ungvari; Anna Csiszar
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2012-03-26       Impact factor: 6.053

8.  Liver-specific knockdown of IGF-1 decreases vascular oxidative stress resistance by impairing the Nrf2-dependent antioxidant response: a novel model of vascular aging.

Authors:  Lora C Bailey-Downs; Matthew Mitschelen; Danuta Sosnowska; Peter Toth; John T Pinto; Praveen Ballabh; M Noa Valcarcel-Ares; Julie Farley; Akos Koller; Jim C Henthorn; Caroline Bass; William E Sonntag; Zoltan Ungvari; Anna Csiszar
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2011-10-21       Impact factor: 6.053

9.  Circulating factors induced by caloric restriction in the nonhuman primate Macaca mulatta activate angiogenic processes in endothelial cells.

Authors:  Anna Csiszar; Danuta Sosnowska; Zsuzsanna Tucsek; Tripti Gautam; Peter Toth; Gyorgy Losonczy; Ricki J Colman; Richard Weindruch; Rozalyn M Anderson; William E Sonntag; Zoltan Ungvari
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2012-08-17       Impact factor: 6.053

10.  Autologous Bone Marrow Mononuclear Cell Transplantation Delays Progression of Carotid Atherosclerosis in Rabbits.

Authors:  Kefei Cui; Xiao Ma; Lie Yu; Chao Jiang; Chao Fu; Xiaojie Fu; Xiaofang Yu; Yuanjing Huang; Suyun Hou; Caifeng Si; Zhengguang Chen; Jing Yu; Jieru Wan; Jian Wang
Journal:  Mol Neurobiol       Date:  2015-08-02       Impact factor: 5.590
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