Literature DB >> 22451468

The emerging role of IGF-1 deficiency in cardiovascular aging: recent advances.

Zoltan Ungvari1, Anna Csiszar.   

Abstract

This review focuses on cardiovascular protective effects of insulin-like growth factor (IGF)-1, provides a landscape of molecular mechanisms involved in cardiovascular alterations in patients and animal models with congenital and adult-onset IGF-1 deficiency, and explores the link between age-related IGF-1 deficiency and the molecular, cellular, and functional changes that occur in the cardiovascular system during aging. Microvascular protection conferred by endocrine and paracrine IGF-1 signaling, its implications for the pathophysiology of cardiac failure and vascular cognitive impairment, and the role of impaired cellular stress resistance in cardiovascular aging considered here are based on emerging knowledge of the effects of IGF-1 on Nrf2-driven antioxidant response.

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Year:  2012        PMID： 22451468      PMCID： PMC3348495          DOI： 10.1093/gerona/gls072

Source DB:  PubMed          Journal:  J Gerontol A Biol Sci Med Sci        ISSN： 1079-5006            Impact factor:   6.053


  147 in total

1.  Intranasal administration of insulin-like growth factor-I bypasses the blood-brain barrier and protects against focal cerebral ischemic damage.

Authors:  X F Liu; J R Fawcett; R G Thorne; T A DeFor; W H Frey
Journal:  J Neurol Sci       Date:  2001-06-15       Impact factor: 3.181

2.  Decreased arteriolar density in endothelial nitric oxide synthase knockout mice is due to hypertension, not to the constitutive defect in endothelial nitric oxide synthase enzyme.

Authors:  Nathalie Kubis; Sandrine Besnard; Jean-Sébastien Silvestre; Michel Feletou; Paul L Huang; Bernard I Lévy; Alain Tedgui
Journal:  J Hypertens       Date:  2002-02       Impact factor: 4.844

3.  Disruption of Nrf2 signaling impairs angiogenic capacity of endothelial cells: implications for microvascular aging.

Authors:  M Noa Valcarcel-Ares; Tripti Gautam; Junie P Warrington; Lora Bailey-Downs; Danuta Sosnowska; Rafael de Cabo; Gyorgy Losonczy; William E Sonntag; Zoltan Ungvari; Anna Csiszar
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2012-01-04       Impact factor: 6.053

4.  Growth hormone increases regional coronary blood flow and capillary density in aged rats.

Authors:  A S Khan; C D Lynch; D C Sane; M C Willingham; W E Sonntag
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2001-08       Impact factor: 6.053

5.  Insulin-like growth factor-1 attenuates the detrimental impact of nonocclusive coronary artery constriction on the heart.

Authors:  B Li; M Setoguchi; X Wang; A M Andreoli; A Leri; A Malhotra; J Kajstura; P Anversa
Journal:  Circ Res       Date:  1999-05-14       Impact factor: 17.367

6.  Long-term deficiency of circulating and hippocampal insulin-like growth factor I induces depressive behavior in adult mice: a potential model of geriatric depression.

Authors:  M Mitschelen; H Yan; J A Farley; J P Warrington; S Han; C B Hereñú; A Csiszar; Z Ungvari; L C Bailey-Downs; C E Bass; W E Sonntag
Journal:  Neuroscience       Date:  2011-04-20       Impact factor: 3.590

7.  Insulin-like growth factor-1 restores erectile function in aged rats: modulation the integrity of smooth muscle and nitric oxide-cyclic guanosine monophosphate signaling activity.

Authors:  Xiao-Yong Pu; Xing-Huan Wang; Wai-Chen Gao; Zhong-Hua Yang; Shi-Lin Li; Huai-Peng Wang; Yi-Long Wu
Journal:  J Sex Med       Date:  2008-03-19       Impact factor: 3.802

8.  The impact of depressive symptoms and chronic diseases on active life expectancy in older Americans.

Authors:  Sandra L Reynolds; William E Haley; Nonna Kozlenko
Journal:  Am J Geriatr Psychiatry       Date:  2008-05       Impact factor: 4.105

Review 9.  The regulation and mechanisms of action of growth hormone and insulin-like growth factor 1 during normal ageing.

Authors:  A P D'Costa; R L Ingram; J E Lenham; W E Sonntag
Journal:  J Reprod Fertil Suppl       Date:  1993

10.  Insulin-like growth factor-I and angiographically documented coronary artery disease.

Authors:  P Spallarossa; C Brunelli; F Minuto; D Caruso; M Battistini; S Caponnetto; R Cordera
Journal:  Am J Cardiol       Date:  1996-01-15       Impact factor: 2.778
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  64 in total

1.  Vitamin D modulates the association of circulating insulin-like growth factor-1 with carotid artery intima-media thickness.

Authors:  Pietro Ameri; Marco Canepa; Patrizia Fabbi; Giovanna Leoncini; Yuri Milaneschi; Michele Mussap; Majd AlGhatrif; Manrico Balbi; Francesca Viazzi; Giovanni Murialdo; Roberto Pontremoli; Claudio Brunelli; Luigi Ferrucci
Journal:  Atherosclerosis       Date:  2014-08-12       Impact factor: 5.162

Review 2.  Novel Biomarkers of Subclinical Cardiac Dysfunction in the General Population.

Authors:  Kamal Shemisa; Anish Bhatt; Daniel Cheeran; Ian J Neeland
Journal:  Curr Heart Fail Rep       Date:  2017-08

Review 3.  Cerebral microhemorrhages: mechanisms, consequences, and prevention.

Authors:  Zoltan Ungvari; Stefano Tarantini; Angelia C Kirkpatrick; Anna Csiszar; Calin I Prodan
Journal:  Am J Physiol Heart Circ Physiol       Date:  2017-03-17       Impact factor: 4.733

4.  Growth hormone alters the glutathione S-transferase and mitochondrial thioredoxin systems in long-living Ames dwarf mice.

Authors:  Lalida Rojanathammanee; Sharlene Rakoczy; Holly M Brown-Borg
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2013-11-27       Impact factor: 6.053

5.  Circulating factors induced by caloric restriction in the nonhuman primate Macaca mulatta activate angiogenic processes in endothelial cells.

Authors:  Anna Csiszar; Danuta Sosnowska; Zsuzsanna Tucsek; Tripti Gautam; Peter Toth; Gyorgy Losonczy; Ricki J Colman; Richard Weindruch; Rozalyn M Anderson; William E Sonntag; Zoltan Ungvari
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2012-08-17       Impact factor: 6.053

6.  An experimental model of partial insulin-like growth factor-1 deficiency in mice.

Authors:  I Castilla-Cortazar; L Guerra; J E Puche; U Muñoz; R Barhoum; E Escudero; J L Lavandera
Journal:  J Physiol Biochem       Date:  2013-09-18       Impact factor: 4.158

7.  Role of 20-HETE, TRPC channels, and BKCa in dysregulation of pressure-induced Ca2+ signaling and myogenic constriction of cerebral arteries in aged hypertensive mice.

Authors:  Peter Toth; Anna Csiszar; Zsuzsanna Tucsek; Danuta Sosnowska; Tripti Gautam; Akos Koller; Michal Laniado Schwartzman; William E Sonntag; Zoltan Ungvari
Journal:  Am J Physiol Heart Circ Physiol       Date:  2013-10-04       Impact factor: 4.733

8.  IGF-1 deficiency in a critical period early in life influences the vascular aging phenotype in mice by altering miRNA-mediated post-transcriptional gene regulation: implications for the developmental origins of health and disease hypothesis.

Authors:  Stefano Tarantini; Cory B Giles; Jonathan D Wren; Nicole M Ashpole; M Noa Valcarcel-Ares; Jeanne Y Wei; William E Sonntag; Zoltan Ungvari; Anna Csiszar
Journal:  Age (Dordr)       Date:  2016-08-26

9.  Endothelin-1-induced focal cerebral ischemia in the growth hormone/IGF-1 deficient Lewis Dwarf rat.

Authors:  Han Yan; Matthew Mitschelen; Peter Toth; Nicole M Ashpole; Julie A Farley; Erik L Hodges; Junie P Warrington; Song Han; Kar-Ming Fung; Anna Csiszar; Zoltan Ungvari; William E Sonntag
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2014-08-06       Impact factor: 6.053

Review 10.  Cardiac aging and insulin resistance: could insulin/insulin-like growth factor (IGF) signaling be used as a therapeutic target?

Authors:  Sihem Boudina
Journal:  Curr Pharm Des       Date:  2013       Impact factor: 3.116
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