Literature DB >> 21660660

Cysteine peptidases of kinetoplastid parasites.

Conor R Caffrey1, Ana-Paula Lima, Dietmar Steverding.   

Abstract

We review Clan CA Family C1 peptidases of kinetoplastid parasites (Trypanosoma and Leishmania) with respect to biochemical and genetic diversity, genomic organization and stage-specificity and control of expression. We discuss their contributions to parasite metabolism, virulence and pathogenesis and modulation of the host's immune response. Their applications as vaccine candidates and diagnostic markers as well as their chemical and genetic validation as drug targets are also summarized.

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Year:  2011        PMID： 21660660     DOI： 10.1007/978-1-4419-8414-2_6

Source DB:  PubMed          Journal:  Adv Exp Med Biol        ISSN： 0065-2598            Impact factor:   2.622


  11 in total

Review 1.  Recent developments in drug discovery for leishmaniasis and human African trypanosomiasis.

Authors:  Advait S Nagle; Shilpi Khare; Arun Babu Kumar; Frantisek Supek; Andriy Buchynskyy; Casey J N Mathison; Naveen Kumar Chennamaneni; Nagendar Pendem; Frederick S Buckner; Michael H Gelb; Valentina Molteni
Journal:  Chem Rev       Date:  2014-11-03       Impact factor: 60.622

Review 2.  Microbial inhibitors of cysteine proteases.

Authors:  Mateusz Kędzior; Rafał Seredyński; Jan Gutowicz
Journal:  Med Microbiol Immunol       Date:  2016-04-05       Impact factor: 3.402

3.  Analysis of a novel cathepsin B circulating antigen and its response to drug treatment in Trichinella-infected mice.

Authors:  Jian-hua Zhan; Jian-ping Yao; Wei Liu; Xu-chu Hu; Zhong-dao Wu; Xing-wang Zhou
Journal:  Parasitol Res       Date:  2013-07-05       Impact factor: 2.289

4.  Reversible cysteine protease inhibitors show promise for a Chagas disease cure.

Authors:  Momar Ndao; Christian Beaulieu; W Cameron Black; Elise Isabel; Fabio Vasquez-Camargo; Milli Nath-Chowdhury; Frédéric Massé; Christophe Mellon; Nathalie Methot; Deborah A Nicoll-Griffith
Journal:  Antimicrob Agents Chemother       Date:  2013-12-09       Impact factor: 5.191

5.  Cure of hookworm infection with a cysteine protease inhibitor.

Authors:  Jon J Vermeire; Lorine D Lantz; Conor R Caffrey
Journal:  PLoS Negl Trop Dis       Date:  2012-07-03

6.  Target-based vs. phenotypic screenings in Leishmania drug discovery: A marriage of convenience or a dialogue of the deaf?

Authors:  Rosa M Reguera; Estefanía Calvo-Álvarez; Raquel Alvarez-Velilla; Rafael Balaña-Fouce
Journal:  Int J Parasitol Drugs Drug Resist       Date:  2014-05-22       Impact factor: 4.077

Review 7.  Cysteine proteases in protozoan parasites.

Authors:  Jair L Siqueira-Neto; Anjan Debnath; Laura-Isobel McCall; Jean A Bernatchez; Momar Ndao; Sharon L Reed; Philip J Rosenthal
Journal:  PLoS Negl Trop Dis       Date:  2018-08-23

8.  Predicting the proteins of Angomonas deanei, Strigomonas culicis and their respective endosymbionts reveals new aspects of the trypanosomatidae family.

Authors:  Maria Cristina Machado Motta; Allan Cezar de Azevedo Martins; Silvana Sant'Anna de Souza; Carolina Moura Costa Catta-Preta; Rosane Silva; Cecilia Coimbra Klein; Luiz Gonzaga Paula de Almeida; Oberdan de Lima Cunha; Luciane Prioli Ciapina; Marcelo Brocchi; Ana Cristina Colabardini; Bruna de Araujo Lima; Carlos Renato Machado; Célia Maria de Almeida Soares; Christian Macagnan Probst; Claudia Beatriz Afonso de Menezes; Claudia Elizabeth Thompson; Daniella Castanheira Bartholomeu; Daniela Fiori Gradia; Daniela Parada Pavoni; Edmundo C Grisard; Fabiana Fantinatti-Garboggini; Fabricio Klerynton Marchini; Gabriela Flávia Rodrigues-Luiz; Glauber Wagner; Gustavo Henrique Goldman; Juliana Lopes Rangel Fietto; Maria Carolina Elias; Maria Helena S Goldman; Marie-France Sagot; Maristela Pereira; Patrícia H Stoco; Rondon Pessoa de Mendonça-Neto; Santuza Maria Ribeiro Teixeira; Talles Eduardo Ferreira Maciel; Tiago Antônio de Oliveira Mendes; Turán P Ürményi; Wanderley de Souza; Sergio Schenkman; Ana Tereza Ribeiro de Vasconcelos
Journal:  PLoS One       Date:  2013-04-03       Impact factor: 3.240

9.  Identification of semicarbazones, thiosemicarbazones and triazine nitriles as inhibitors of Leishmania mexicana cysteine protease CPB.

Authors:  Jörg Schröder; Sandra Noack; Richard J Marhöfer; Jeremy C Mottram; Graham H Coombs; Paul M Selzer
Journal:  PLoS One       Date:  2013-10-16       Impact factor: 3.240

10.  Odanacatib, a Cathepsin K Cysteine Protease Inhibitor, Kills Hookworm In Vivo.

Authors:  Jon J Vermeire; Brian M Suzuki; Conor R Caffrey
Journal:  Pharmaceuticals (Basel)       Date:  2016-07-04
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