Literature DB >> 2165982

ESR spin trapping detection of hydroxyl radicals in the reactions of Cr(V) complexes with hydrogen peroxide.

X L Shi1, N S Dalal.   

Abstract

Electron spin resonance (ESR) measurements provide direct evidence for the involvement of Cr(V) in the reduction of Cr(VI) by NAD(P)H. Addition of hydrogen peroxide (H2O2) to NAD(P)H-Cr(VI) reaction mixtures suppresses the Cr(V) signal and generates hydroxyl (.OH) radicals (as detected via spin trapping), suggesting that Cr(V) reacts with H2O2 to generate the .OH radicals. Reaction between H2O2 and a Cr(V)-glutathione complex, and between H2O2 and several Cr(V)-carboxylato complexes also produces .OH radicals. These results suggest that Cr(V) complexes catalyze the generation of .OH radicals from H2O2, and that .OH radicals might play a significant role in the mechanism of Cr(VI) cytotoxicity.

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Year:  1990        PMID： 2165982     DOI： 10.3109/10715769009145929

Source DB:  PubMed          Journal:  Free Radic Res Commun        ISSN： 8755-0199


  13 in total

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