| Literature DB >> 2165866 |
R Offringa1, S Gebel, H van Dam, M Timmers, A Smits, R Zwart, B Stein, J L Bos, A van der Eb, P Herrlich.
Abstract
Adenovirus E1a represses transcription of the collagenase gene via the phorbol ester-responsive element (collTRE). The mechanism involves inhibition of the trans-activating function of the transcription factor AP-1 without reduction of its synthesis and without any apparent change in DNA binding or composition. The ability of E1a to downmodulate AP-1 is a unique property among dominant oncogenes. This repression depends on conserved region 1, one of the transforming domains of E1a, indicating that it is an integral feature of adenovirus transformation.Entities:
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Year: 1990 PMID： 2165866 DOI： 10.1016/0092-8674(90)90017-9
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582