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Literature DB >> 2165018

Primary structure of the deoxyguanosine triphosphate triphosphohydrolase-encoding gene (dgt) of Escherichia coli.

Abstract

The complete nucleotide sequence has been determined for a 2027-bp region that encompasses the structural gene (dgt) encoding deoxyguanosine triphosphate triphosphohydrolase (dGTPase) from Escherichia coli. The gene resides between the htrA and dapD loci at 3.75-3.8' on the bacterial chromosome. Using homologous recombination in a recD recipient, a dgt- bacterial strain was constructed that was deficient in producing functional dGTPase. Comparison of dGTP pools in this and other strains revealed that dGTPase synthesized in vivo does to some degree modulate the level of dGTP in the bacterial cell, yet the magnitude of this modulation may be insufficient to explain the physiological function of dGTPase.

Entities: Chemical Disease Gene Species

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Year: 1990 PMID： 2165018 DOI： 10.1016/0378-1119(90)90200-b

Source DB: PubMed Journal: Gene ISSN： 0378-1119 Impact factor: 3.688

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Cited

12 in total

1. A novel mutator of Escherichia coli carrying a defect in the dgt gene, encoding a dGTP triphosphohydrolase.

Authors: Damian Gawel; Michael D Hamilton; Roel M Schaaper
Journal: J Bacteriol Date: 2008-09-05 Impact factor: 3.490

2. Synthetic lethality with the dut defect in Escherichia coli reveals layers of DNA damage of increasing complexity due to uracil incorporation.

Authors: Helen Ting; Elena A Kouzminova; Andrei Kuzminov
Journal: J Bacteriol Date: 2008-06-27 Impact factor: 3.490

10. The mutT defect does not elevate chromosomal fragmentation in Escherichia coli because of the surprisingly low levels of MutM/MutY-recognized DNA modifications.

Authors: Ella Rotman; Andrei Kuzminov
Journal: J Bacteriol Date: 2007-07-06 Impact factor: 3.490

Primary structure of the deoxyguanosine triphosphate triphosphohydrolase-encoding gene (dgt) of Escherichia coli.

1. A novel mutator of Escherichia coli carrying a defect in the dgt gene, encoding a dGTP triphosphohydrolase.

2. Synthetic lethality with the dut defect in Escherichia coli reveals layers of DNA damage of increasing complexity due to uracil incorporation.

3. Folding-based suppression of extracytoplasmic toxicity conferred by processing-defective LamB.

Review 4. Linkage map of Escherichia coli K-12, edition 10: the traditional map.

5. The dgt gene of Escherichia coli facilitates thymine utilization in thymine-requiring strains.

6. Structure of Escherichia coli dGTP triphosphohydrolase: a hexameric enzyme with DNA effector molecules.

7. Elevated Levels of DNA Strand Breaks Induced by a Base Analog in the Human Cell Line with the P32T ITPA Variant.

8. dGTP triphosphohydrolase, a unique enzyme confined to members of the family Enterobacteriaceae.

Review 9. Functions of the gene products of Escherichia coli.

10. The mutT defect does not elevate chromosomal fragmentation in Escherichia coli because of the surprisingly low levels of MutM/MutY-recognized DNA modifications.