Literature DB >> 2164775

High incidence of Epstein-Barr virus genomes in Hodgkin's disease.

H Herbst1, G Niedobitek, M Kneba, M Hummel, T Finn, I Anagnostopoulos, M Bergholz, G Krieger, H Stein.   

Abstract

Tissue specimens from 198 cases of Hodgkin's disease and 151 non-Hodgkin lymphomas, as well as 34 nonmalignant lymph node biopsies were examined for the presence of Epstein-Barr virus (EBV) DNA by polymerase chain reaction. Epstein-Barr virus-specific DNA sequences were detected in DNA extracts from frozen and/or paraffin-embedded tissues of 58% of Hodgkin's disease cases. High and low grade non-Hodgkin lymphomas as well as chronic lymphocytic leukemia biopsies contained EBV DNA in 26%, 14%, and 7% of the cases, respectively. Ten percent of the control lymph nodes with normal histology were EBV positive. In Hodgkin's disease biopsies, subsequent in situ hybridization revealed an exclusive localization of the viral DNA in the tumor cells. These findings suggest an involvement of EBV in the pathogenesis of Hodgkin's disease in a substantial proportion of cases.

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Year:  1990        PMID： 2164775      PMCID： PMC1877694     

Source DB:  PubMed          Journal:  Am J Pathol        ISSN： 0002-9440            Impact factor:   4.307


  18 in total

1.  Epstein-Barr viral DNA in tissues of Hodgkin's disease.

Authors:  L M Weiss; J G Strickler; R A Warnke; D T Purtilo; J Sklar
Journal:  Am J Pathol       Date:  1987-10       Impact factor: 4.307

2.  Antibody to Epstein-Barr virus and cellular immunity in Hodgkin's disease and chronic lymphatic leukemia.

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Journal:  Int J Cancer       Date:  1973-01-15       Impact factor: 7.396

3.  EBV DNA in biopsies of Burkitt tumours and anaplastic carcinomas of the nasopharynx.

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Journal:  Nature       Date:  1970-12-12       Impact factor: 49.962

4.  Epstein-Barr virus (EBV)-associated antibody patterns in malignant lymphoma and leukemia. I. Hodgkin's disease.

Authors:  B Johansson; G Klein; W Henle; G Henle
Journal:  Int J Cancer       Date:  1970-11-15       Impact factor: 7.396

Review 5.  Epidemiology of Hodgkin's disease.

Authors:  N Gutensohn; P Cole
Journal:  Semin Oncol       Date:  1980-06       Impact factor: 4.929

6.  Long internal direct repeat in Epstein-Barr virus DNA.

Authors:  A Cheung; E Kieff
Journal:  J Virol       Date:  1982-10       Impact factor: 5.103

7.  Identification of Epstein-Barr virus-infected cells in tonsils of acute infectious mononucleosis by in situ hybridization.

Authors:  G Niedobitek; S Hamilton-Dutoit; H Herbst; T Finn; M Vetner; G Pallesen; H Stein
Journal:  Hum Pathol       Date:  1989-08       Impact factor: 3.466

8.  Demonstration of monoclonal EBV genomes in Hodgkin's disease and Ki-1-positive anaplastic large cell lymphoma by combined Southern blot and in situ hybridization.

Authors:  I Anagnostopoulos; H Herbst; G Niedobitek; H Stein
Journal:  Blood       Date:  1989-08-01       Impact factor: 22.113

9.  A complete set of overlapping cosmid clones of M-ABA virus derived from nasopharyngeal carcinoma and its similarity to other Epstein-Barr virus isolates.

Authors:  A Polack; G Hartl; U Zimber; U K Freese; G Laux; K Takaki; B Hohn; L Gissmann; G W Bornkamm
Journal:  Gene       Date:  1984-03       Impact factor: 3.688

10.  Lymphoproliferative disorders in cardiac transplant recipients are multiclonal lymphomas.

Authors:  M L Cleary; J Sklar
Journal:  Lancet       Date:  1984-09-01       Impact factor: 79.321
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  37 in total

1.  Detection of Epstein-Barr virus genome in Ki-1 (CD30)-positive, large-cell anaplastic lymphomas using the polymerase chain reaction.

Authors:  C W Ross; J A Schlegelmilch; T M Grogan; L M Weiss; B Schnitzer; C A Hanson
Journal:  Am J Pathol       Date:  1992-08       Impact factor: 4.307

2.  Expression of Epstein-Barr virus genes and of lymphocyte activation molecules in undifferentiated nasopharyngeal carcinomas.

Authors:  G Niedobitek; L S Young; C K Sam; L Brooks; U Prasad; A B Rickinson
Journal:  Am J Pathol       Date:  1992-04       Impact factor: 4.307

Review 3.  The molecular biology of B-cell lymphoma: clinicopathologic implications.

Authors:  P M Kluin; J H van Krieken
Journal:  Ann Hematol       Date:  1991-04       Impact factor: 3.673

4.  Epstein-Barr virus and Hodgkin's disease. A correlative in situ hybridization and polymerase chain reaction study.

Authors:  L M Weiss; Y Y Chen; X F Liu; D Shibata
Journal:  Am J Pathol       Date:  1991-12       Impact factor: 4.307

Review 5.  Control of viral disease: the development of Epstein-Barr virus vaccines.

Authors:  A J Morgan
Journal:  Springer Semin Immunopathol       Date:  1991

6.  Epstein-Barr viral genome in lymph nodes from patients with Hodgkin's disease may not be specific to Reed-Sternberg cells.

Authors:  A Masih; D Weisenburger; M Duggan; J Armitage; R Bashir; D Mitchell; R Wickert; D T Purtilo
Journal:  Am J Pathol       Date:  1991-07       Impact factor: 4.307

7.  Biochemical characterization of Epstein-Barr virus nuclear antigen 2A.

Authors:  F A Grässer; P Haiss; S Göttel; N Mueller-Lantzsch
Journal:  J Virol       Date:  1991-07       Impact factor: 5.103

8.  Absence of Epstein-Barr virus in testicular germ cell tumours: a study of 21 cases using in situ hybridisation.

Authors:  N J Trendell-Smith; A Agathanggelou; H Herbst; C M Collins; N Rooney; G Niedobitek
Journal:  Clin Mol Pathol       Date:  1995-04

9.  Epstein-Barr virus latent membrane protein expression in Hodgkin and Reed-Sternberg cells.

Authors:  H Herbst; F Dallenbach; M Hummel; G Niedobitek; S Pileri; N Müller-Lantzsch; H Stein
Journal:  Proc Natl Acad Sci U S A       Date:  1991-06-01       Impact factor: 11.205

Review 10.  Epidemiology of Hodgkin's disease and non-Hodgkin's lymphoma.

Authors:  A J Swerdlow
Journal:  Eur J Nucl Med Mol Imaging       Date:  2003-05-07       Impact factor: 9.236
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