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Literature DB >> 216471

Effects of vitamin D3 metabolites on bone cell calcium transport.

Abstract

The vitamin D3 metabolite, 25-hydroxycholecalciferol, at concentrations of 0.01 to 10.0 microgram/ml, decreased calcium uptake by isolated bone cells. The effect occurred within 1 min after the simultaneous addition of metabolite and 45Ca. Lactic acid and ATP production by the cells was not affected. 24(R), 25-dihydroxycholecalciferol produced a similar decrease in calcium uptake. Vitamin D3 had no effect at concentrations from 0.01 to 10.0 micrograms/ml. No effect of 1,25-dihydroxycholecalciferol on calcium uptake was observed with concentrations from 0.1 to 100 ng/ml and various preincubation periods extending to 2 h. None of the agents had any effect on calcium efflux. The effects of 25-hydroxycholecalciferol and 24(R), 25-dihydroxycholecalciferol on calcium uptake were not seen in isolated fetal rat skin cell preparations.

Entities: Chemical Species

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Year: 1978 PMID： 216471 DOI： 10.1007/bf02013236

Source DB: PubMed Journal: Calcif Tissue Res ISSN： 0008-0594

22 in total

1. Bone resorbing activities of 24-hydroxy stereoisomers of 24-hydroxyvitamin D3 and 24,25-dihydroxyvitamin D3.

Authors: P H Stern; H F DeLuca; N Ikekawa
Journal: Biochem Biophys Res Commun Date: 1975-12-01 Impact factor: 3.575

2. Parathyromimetic effects of the ionophore, A23187, on bone cells and organ cultures.

Authors: R Dziak; P Stern
Journal: Biochem Biophys Res Commun Date: 1975-08-18 Impact factor: 3.575

3. Studies on calciferol metabolism. V. The occurrence and biological activity of 1,25-dihydroxy-vitamin D 3 in bone.

Authors: R G Wong; J F Myrtle; H C Tsai; A W Norman
Journal: J Biol Chem Date: 1972-09-25 Impact factor: 5.157

4. The metabolism of vitamin D 3 in the chick.

Authors: M R Haussler; H Rasmussen
Journal: J Biol Chem Date: 1972-04-25 Impact factor: 5.157

5. Calcium transport in isolated bone cells. III. Effects of parathyroid hormone and cyclic 3',5'-AMP.

Authors: R Dziak; P H Stern
Journal: Endocrinology Date: 1975-11 Impact factor: 4.736

6. Bone resorbing activity of vitamin D metabolites and congeners in vitro: influence of hydroxyl substituents in the A ring.

Authors: P H Stern; C L Trummel; H K Schnoes; H F Deluca
Journal: Endocrinology Date: 1975-12 Impact factor: 4.736

7. 1,25-dihydroxycholecalciferol and parathormone: effects on isolated osteoclast-like and osteoblast-like cells.

Authors: G L Wong; R A Luben; D V Cohn
Journal: Science Date: 1977-08-12 Impact factor: 47.728

8. 25-hydroxyvitamin D: autoradiographic evidence of sites of action in epiphyseal cartilage and bone.

Authors: F H Wezeman
Journal: Science Date: 1976-12-03 Impact factor: 47.728

9. The action of two metabolites of vitamin D3; 25,26-dihydroxycholecalciferol (25,26(OH)2D3) and 24, 25-dihydroxycholecalciferol (24,25(OH)2D3) on bone resorption.

Authors: M Peacock; G A Taylor; J Redel
Journal: FEBS Lett Date: 1976-03-01 Impact factor: 4.124

8. Actions of parathyroid hormone and 1,25-dihydroxycholecalciferol on citrate decarboxylation in osteoblast-like bone cells differ in calcium requirement and in sensitivity to trifluoperazine.

Authors: G L Wong
Journal: Calcif Tissue Int Date: 1983-07 Impact factor: 4.333

8 in total

Effects of vitamin D3 metabolites on bone cell calcium transport.

1. Bone resorbing activities of 24-hydroxy stereoisomers of 24-hydroxyvitamin D3 and 24,25-dihydroxyvitamin D3.

2. Parathyromimetic effects of the ionophore, A23187, on bone cells and organ cultures.

3. Studies on calciferol metabolism. V. The occurrence and biological activity of 1,25-dihydroxy-vitamin D 3 in bone.

4. The metabolism of vitamin D 3 in the chick.

5. Calcium transport in isolated bone cells. III. Effects of parathyroid hormone and cyclic 3',5'-AMP.

6. Bone resorbing activity of vitamin D metabolites and congeners in vitro: influence of hydroxyl substituents in the A ring.

7. 1,25-dihydroxycholecalciferol and parathormone: effects on isolated osteoclast-like and osteoblast-like cells.

8. 25-hydroxyvitamin D: autoradiographic evidence of sites of action in epiphyseal cartilage and bone.

9. The action of two metabolites of vitamin D3; 25,26-dihydroxycholecalciferol (25,26(OH)2D3) and 24, 25-dihydroxycholecalciferol (24,25(OH)2D3) on bone resorption.

10. Inhibition of the metabolism of 25-hydroxycholecalciferol by actinomycin D and cycloheximide.

1. In vitro effects of vitamin D3 metabolites on rat calvaria cAMP content.

2. Cell density-dependent vitamin D effects on calcium accumulation in rat osteogenic sarcoma cells (ROS 17/2).

3. Effects of vitamin D metabolites and analogs on bone collagen synthesis in vitro.

4. Ionophore A23187 promotes osteoclast formation in bone organ culture.

5. A monolog on analogs: in vitro effects of vitamin D metabolites and consideration of the mineralization question.

6. The effect of adsorbed vitamin D and K to hydroxyapatite on ALP activity of MC3T3-E1 cell.

7. Benzo(B)thiophene-2-carboxylic acid: calcium uptake and cyclic AMP production in isolated bone cells.

8. Actions of parathyroid hormone and 1,25-dihydroxycholecalciferol on citrate decarboxylation in osteoblast-like bone cells differ in calcium requirement and in sensitivity to trifluoperazine.