Literature DB >> 21646489

Susceptibility of vertilmicin to modifications by three types of recombinant aminoglycoside-modifying enzymes.

Min Yuan1, Hui Han, Cong-Ran Li, Xin-Yi Yang, Guo-Qing Li, Shan Cen, Xi-Xiong Kang, Shu-Yi Si, Jian-Dong Jiang, Xue-Fu You.   

Abstract

The susceptibilities of vertilmicin and seven reference aminoglycosides to modifications by six recombinant aminoglycoside-modifying enzymes, AAC(6')-Ie, APH(2'')-Ia, AAC(6')-Ie-APH(2'')-Ia, ANT(2'')-Ia, AAC(6')-Ib, and AAC(6')-Ib-cr, were studied by coupled spectrophotometric assays in microtiter plates. In comparison to other aminoglycosides, the susceptibility of vertilmicin was 45.8- to 250.0-fold lower for AAC(6')-Ie acetylation, 39.2- to 116.7-fold lower for AAC(6')-Ie-APH(2'')-Ia acetylation, and 1.8- to 7.5-fold lower for ANT(2'')-Ia adenylation (except that shown by amikacin) while relatively comparable for AAC(6')-Ib acetylation, AAC(6')-Ib-cr acetylation, APH(2'')-Ia phosphorylation, and AAC(6')-Ie-APH(2'')-Ia phosphorylation.

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Year:  2011        PMID： 21646489      PMCID： PMC3147634          DOI： 10.1128/AAC.00300-11

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  20 in total

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Review 5.  Versatility of aminoglycosides and prospects for their future.

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Review 7.  Molecular genetics of aminoglycoside resistance genes and familial relationships of the aminoglycoside-modifying enzymes.

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8.  In vitro antibacterial activity of vertilmicin and its susceptibility to modifications by the recombinant AAC6'-APH2'' enzyme.

Authors:  Cong-Ran Li; Xin-Yi Yang; Ren-Hui Lou; Wei-Xin Zhang; Yue-Ming Wang; Min Yuan; Yi Li; Hui-Zhen Chen; Bin Hong; Cheng-Hang Sun; Li-Xun Zhao; Zhuo-Rong Li; Jian-Dong Jiang; Xue-Fu You
Journal:  Antimicrob Agents Chemother       Date:  2008-08-18       Impact factor: 5.191

9.  Mechanistic and structural analysis of aminoglycoside N-acetyltransferase AAC(6')-Ib and its bifunctional, fluoroquinolone-active AAC(6')-Ib-cr variant.

Authors:  Matthew W Vetting; Chi Hye Park; Subray S Hegde; George A Jacoby; David C Hooper; John S Blanchard
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10.  Mechanistic characterization of the bifunctional aminoglycoside-modifying enzyme AAC(3)-Ib/AAC(6')-Ib' from Pseudomonas aeruginosa.

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Journal:  Biochemistry       Date:  2007-04-07       Impact factor: 3.162
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  2 in total

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Journal:  Antimicrob Agents Chemother       Date:  2012-01-30       Impact factor: 5.191

2.  Genetic basis of high level aminoglycoside resistance in Acinetobacter baumannii from Beijing, China.

Authors:  Lu Nie; Yuemeng Lv; Min Yuan; Xinxin Hu; Tongying Nie; Xinyi Yang; Guoqing Li; Jing Pang; Jingpu Zhang; Congran Li; Xiukun Wang; Xuefu You
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