| Literature DB >> 21643987 |
Shala Ghaderi Berntsson1, Carl Wibom, Sara Sjöström, Roger Henriksson, Thomas Brännström, Helle Broholm, Christoffer Johansson, Sarah J Fleming, Patricia A McKinney, Lara Bethke, Richard Houlston, Anja Smits, Ulrika Andersson, Beatrice S Melin.
Abstract
The purpose of this study was to explore the variation in DNA repair genes in adults with WHO grade II and III gliomas and their relationship to patient survival. We analysed a total of 1,458 tagging single-nucleotide polymorphisms (SNPs) that were selected to cover DNA repair genes, in 81 grade II and grade III gliomas samples, collected in Sweden and Denmark. The statistically significant genetic variants from the first dataset (P < 0.05) were taken forward for confirmation in a second dataset of 72 grade II and III gliomas from northern UK. In this dataset, eight gene variants mapping to five different DNA repair genes (ATM, NEIL1, NEIL2, ERCC6 and RPA4) which were associated with survival. Finally, these eight genetic variants were adjusted for treatment, malignancy grade, patient age and gender, leaving one variant, rs4253079, mapped to ERCC6, with a significant association to survival (OR 0.184, 95% CI 0.054-0.63, P = 0.007). We suggest a possible novel association between rs4253079 and survival in this group of patients with low-grade and anaplastic gliomas that needs confirmation in larger datasets.Entities:
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Year: 2011 PMID： 21643987 DOI： 10.1007/s11060-011-0614-5
Source DB: PubMed Journal: J Neurooncol ISSN： 0167-594X Impact factor: 4.130