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Literature DB >> 30830525

Maintenance of Intestinal Epithelial Homeostasis by Zinc Transporters.

Wakana Ohashi¹, Takafumi Hara², Teruhisa Takagishi², Koji Hase³, Toshiyuki Fukada^4,5,6.

Abstract

Zinc is an essential micronutrient for normal organ function, and dysregulation of zinc metabolism has been implicated in a wide range of diseases. Emerging evidence has revealed that zinc transporters play diverse roles in cellular homeostasis and function by regulating zinc trafficking via organelles or the plasma membrane. In the gastrointestinal tract, zinc deficiency leads to diarrhea and dysfunction of intestinal epithelial cells. Studies also showed that zinc transporters are very important in intestinal epithelial homeostasis. In this review, we describe the physiological roles of zinc transporters in intestinal epithelial functions and relevance of zinc transporters in gastrointestinal diseases.

Entities: Disease

Keywords: Cancer; Inflammatory bowel disease; Intestinal epithelial cells; Zinc; Zinc transporter

Year: 2019 PMID： 30830525 DOI： 10.1007/s10620-019-05561-2

Source DB: PubMed Journal: Dig Dis Sci ISSN： 0163-2116 Impact factor: 3.199

170 in total

Review 1. Acrodermatitis enteropathica.

Authors: V N Sehgal; S Jain
Journal: Clin Dermatol Date: 2000 Nov-Dec Impact factor: 3.541

2. Secretion of microbicidal alpha-defensins by intestinal Paneth cells in response to bacteria.

Authors: T Ayabe; D P Satchell; C L Wilson; W C Parks; M E Selsted; A J Ouellette
Journal: Nat Immunol Date: 2000-08 Impact factor: 25.606

Review 3. The multifaceted Paneth cell.

Authors: E M Porter; C L Bevins; D Ghosh; T Ganz
Journal: Cell Mol Life Sci Date: 2002-01 Impact factor: 9.261

4. Identification of SLC39A4, a gene involved in acrodermatitis enteropathica.

Authors: Sébastien Küry; Brigitte Dréno; Stéphane Bézieau; Stéphanie Giraudet; Monia Kharfi; Ridha Kamoun; Jean-Paul Moisan
Journal: Nat Genet Date: 2002-06-17 Impact factor: 38.330

Review 5. Human zinc deficiency.

Authors: M Hambidge
Journal: J Nutr Date: 2000-05 Impact factor: 4.798

6. Differential regulation of zinc transporter 1, 2, and 4 mRNA expression by dietary zinc in rats.

Authors: J P Liuzzi; R K Blanchard; R J Cousins
Journal: J Nutr Date: 2001-01 Impact factor: 4.798

7. A novel member of a zinc transporter family is defective in acrodermatitis enteropathica.

Authors: Kun Wang; Bing Zhou; Yien-Ming Kuo; Jason Zemansky; Jane Gitschier
Journal: Am J Hum Genet Date: 2002-05-24 Impact factor: 11.025

Review 8. Zinc and intestinal function.

Authors: C E Semrad
Journal: Curr Gastroenterol Rep Date: 1999-10

9. Enhanced expression of transforming growth factor (TGF) -alpha precursor and TGF-beta1 during Paneth cell regeneration.

Authors: H Seno; M Sawada; H Fukuzawa; Y Morita; S Takaishi; H Hiai; T Chiba
Journal: Dig Dis Sci Date: 2001-05 Impact factor: 3.199

10. Osteopenia and male-specific sudden cardiac death in mice lacking a zinc transporter gene, Znt5.

Authors: Koichi Inoue; Koichi Matsuda; Makoto Itoh; Hiroshi Kawaguchi; Hitonobu Tomoike; Teruhiko Aoyagi; Ryozo Nagai; Masatsugu Hori; Yusuke Nakamura; Toshihiro Tanaka
Journal: Hum Mol Genet Date: 2002-07-15 Impact factor: 6.150

5 in total

Review 1. The role of labile Zn²⁺ and Zn²⁺-transporters in the pathophysiology of mitochondria dysfunction in cardiomyocytes.

Authors: Belma Turan; Erkan Tuncay
Journal: Mol Cell Biochem Date: 2020-11-22 Impact factor: 3.396

2. The ZIP8/SIRT1 axis regulates alveolar progenitor cell renewal in aging and idiopathic pulmonary fibrosis.

Authors: Jiurong Liang; Guanling Huang; Xue Liu; Forough Taghavifar; Ningshan Liu; Yizhou Wang; Nan Deng; Changfu Yao; Ting Xie; Vrishika Kulur; Kristy Dai; Ankita Burman; Simon C Rowan; S Samuel Weigt; John Belperio; Barry Stripp; William C Parks; Dianhua Jiang; Paul W Noble
Journal: J Clin Invest Date: 2022-06-01 Impact factor: 19.456

Maintenance of Intestinal Epithelial Homeostasis by Zinc Transporters.

Review 1. Acrodermatitis enteropathica.

2. Secretion of microbicidal alpha-defensins by intestinal Paneth cells in response to bacteria.

Review 3. The multifaceted Paneth cell.

4. Identification of SLC39A4, a gene involved in acrodermatitis enteropathica.

Review 5. Human zinc deficiency.

6. Differential regulation of zinc transporter 1, 2, and 4 mRNA expression by dietary zinc in rats.

7. A novel member of a zinc transporter family is defective in acrodermatitis enteropathica.

Review 8. Zinc and intestinal function.

9. Enhanced expression of transforming growth factor (TGF) -alpha precursor and TGF-beta1 during Paneth cell regeneration.

10. Osteopenia and male-specific sudden cardiac death in mice lacking a zinc transporter gene, Znt5.

Review 1. The role of labile Zn²⁺ and Zn²⁺-transporters in the pathophysiology of mitochondria dysfunction in cardiomyocytes.

2. The ZIP8/SIRT1 axis regulates alveolar progenitor cell renewal in aging and idiopathic pulmonary fibrosis.

Review 3. Role of ion channels in gastrointestinal cancer.

Review 4. Zinc is an important inter-kingdom signal between the host and microbe.

Review 5. Zinc as a countermeasure for cadmium toxicity.

Review 1. Acrodermatitis enteropathica.

Review 3. The multifaceted Paneth cell.

Review 5. Human zinc deficiency.

Review 8. Zinc and intestinal function.

Review 1. The role of labile Zn2+ and Zn2+-transporters in the pathophysiology of mitochondria dysfunction in cardiomyocytes.

Review 3. Role of ion channels in gastrointestinal cancer.

Review 4. Zinc is an important inter-kingdom signal between the host and microbe.

Review 5. Zinc as a countermeasure for cadmium toxicity.

Review 1. The role of labile Zn²⁺ and Zn²⁺-transporters in the pathophysiology of mitochondria dysfunction in cardiomyocytes.