CONTEXT: The aerosol components responsible for the adverse health effects of the exposure to particulate matter (PM) have not been conclusively identified, and there is especially little information on the role of particulate organic compounds (POC). OBJECTIVE: This study evaluated the role of PM and POC with regard to daily symptoms. METHODS: One hundred and fifty-three myocardial infarction survivors from Augsburg, Germany, recorded daily occurrence of different symptoms in winter 2003/2004. Ambient concentrations of PM with a diameter <2.5 μm (PM(2.5)), particle number concentration (PNC), PM(2.5)-bound hopanes, and polycyclic aromatic hydrocarbons (PAH) were quantified. Data were analyzed using generalized estimating equations adjusting for meteorological and other time-variant confounders. RESULTS: The odds for avoidance of physically demanding activities due to heart problems increased immediately associated with most POC measures (e.g. 5% per 1.08 ng/m(3) increase in benzo[a]pyrene, 95%-confidence interval (CI):1-9%) and tended to a delayed decrease. After a 2-day delayed decrease associated with hopanes, the odds for shortness of breath increased consistently after 3 days with almost all POC measures (e.g. 4% per 0.21 ng/m(3) increase in 17α(H), 21β(H)-hopane, CI: 1-8%). The odds for heart palpitations marginally increased immediately in association with PNC (8% per 8146 cm(-3) increase in PNC, CI: 0-16%). CONCLUSIONS: The study showed an association between PM, particle-bound POC, and daily symptoms. The organic compounds may be causally related with cardiovascular health or act rather as indicators for traffic- and combustion-related particles.
CONTEXT: The aerosol components responsible for the adverse health effects of the exposure to particulate matter (PM) have not been conclusively identified, and there is especially little information on the role of particulate organic compounds (POC). OBJECTIVE: This study evaluated the role of PM and POC with regard to daily symptoms. METHODS: One hundred and fifty-three myocardial infarction survivors from Augsburg, Germany, recorded daily occurrence of different symptoms in winter 2003/2004. Ambient concentrations of PM with a diameter <2.5 μm (PM(2.5)), particle number concentration (PNC), PM(2.5)-bound hopanes, and polycyclic aromatic hydrocarbons (PAH) were quantified. Data were analyzed using generalized estimating equations adjusting for meteorological and other time-variant confounders. RESULTS: The odds for avoidance of physically demanding activities due to heart problems increased immediately associated with most POC measures (e.g. 5% per 1.08 ng/m(3) increase in benzo[a]pyrene, 95%-confidence interval (CI):1-9%) and tended to a delayed decrease. After a 2-day delayed decrease associated with hopanes, the odds for shortness of breath increased consistently after 3 days with almost all POC measures (e.g. 4% per 0.21 ng/m(3) increase in 17α(H), 21β(H)-hopane, CI: 1-8%). The odds for heart palpitations marginally increased immediately in association with PNC (8% per 8146 cm(-3) increase in PNC, CI: 0-16%). CONCLUSIONS: The study showed an association between PM, particle-bound POC, and daily symptoms. The organic compounds may be causally related with cardiovascular health or act rather as indicators for traffic- and combustion-related particles.
Authors: Dongni Ye; Mitchel Klein; Howard H Chang; Jeremy A Sarnat; James A Mulholland; Eric S Edgerton; Andrea Winquist; Paige E Tolbert; Stefanie Ebelt Sarnat Journal: Epidemiology Date: 2017-03 Impact factor: 4.822
Authors: Joey S Stevens; Stephanie Padilla; David M DeMarini; Deborah L Hunter; W Kyle Martin; Leslie C Thompson; M Ian Gilmour; Mehdi S Hazari; Aimen K Farraj Journal: Toxicol Sci Date: 2018-02-01 Impact factor: 4.849
Authors: Osnat Wine; Alvaro Osornio Vargas; Sandra M Campbell; Vahid Hosseini; Charles Robert Koch; Mahdi Shahbakhti Journal: Int J Environ Res Public Health Date: 2022-01-28 Impact factor: 3.390
Authors: Marianthi-Anna Kioumourtzoglou; Antonella Zanobetti; Joel D Schwartz; Brent A Coull; Francesca Dominici; Helen H Suh Journal: Environ Health Date: 2013-08-27 Impact factor: 5.984