BACKGROUND: Multiple calcified primary central nervous system lymphoma (PCNSL) is extremely rare in childhood. METHODS: We report a 4-year-old boy suffering from multiple calcified B-cell lymphoma in the brain with immunodeficiency. RESULTS: The boy had a history of walking weakness and seizure for 4 months. The serum levels of immunoglobulin G, A and M were decreased. Brain MRI showed multiple lesions which had ring enhancement. CT showed calcification in all of the lesions. The boy was firstly misdiagnosed with multiple chronic brain abscesses. Pathological analysis of biopsy confirmed the diagnosis of anaplastic diffuse large B-cell lymphoma. CONCLUSION: PCNSL should be included in the differential diagnosis of intracranial mass with calcification.
BACKGROUND: Multiple calcified primary central nervous system lymphoma (PCNSL) is extremely rare in childhood. METHODS: We report a 4-year-old boy suffering from multiple calcified B-cell lymphoma in the brain with immunodeficiency. RESULTS: The boy had a history of walking weakness and seizure for 4 months. The serum levels of immunoglobulin G, A and M were decreased. Brain MRI showed multiple lesions which had ring enhancement. CT showed calcification in all of the lesions. The boy was firstly misdiagnosed with multiple chronic brain abscesses. Pathological analysis of biopsy confirmed the diagnosis of anaplastic diffuse large B-cell lymphoma. CONCLUSION: PCNSL should be included in the differential diagnosis of intracranial mass with calcification.
Authors: Oussama Abla; John T Sandlund; Lillian Sung; Penelope Brock; Rob Corbett; Ivan Kirov; Timothy C Griffin; Susan Blaser; Sheila Weitzman Journal: Pediatr Blood Cancer Date: 2006-12 Impact factor: 3.167
Authors: A Coulon; F Lafitte; K Hoang-Xuan; N Martin-Duverneuil; K Mokhtari; J Blustajn; J Chiras Journal: Eur Radiol Date: 2001-09-21 Impact factor: 5.315
Authors: B K Kleinschmidt-DeMasters; Denise M Damek; Kevin O Lillehei; Ahmed Dogan; Caterina Giannini Journal: J Neuropathol Exp Neurol Date: 2008-11 Impact factor: 3.685
Authors: Heike Thorer; Martin Zimmermann; Olga Makarova; Ilske Oschlies; Wolfram Klapper; Peter Lang; Arend von Stackelberg; Gudrun Fleischhack; Jennifer Worch; Heribert Juergens; Wilhelm Woessmann; Alfred Reiter; Birgit Burkhardt Journal: Haematologica Date: 2014-08-08 Impact factor: 9.941