CONTEXT: The introduction of genome- and epigenome-wide screening techniques has dramatically improved our understanding of the molecular mechanisms underlying the development of pancreatic cancer. There are now 3 recognized histologic precursors of pancreatic cancer: pancreatic intraepithelial neoplasia, intraductal papillary mucinous neoplasm, and mucinous cystic neoplasm. Each of these precursor lesions is associated with specific molecular alterations. OBJECTIVE: To understand the molecular characteristics of pancreatic ductal adenocarcinoma and its precursor lesions. DATA SOURCES: PubMed (US National Library of Medicine). CONCLUSIONS: In this review, we briefly summarize recent research findings on the genetics and epigenetics of pancreatic cancer. In addition, we characterize these molecular alterations in the context of the histologic subtypes of pancreatic cancer.
CONTEXT: The introduction of genome- and epigenome-wide screening techniques has dramatically improved our understanding of the molecular mechanisms underlying the development of pancreatic cancer. There are now 3 recognized histologic precursors of pancreatic cancer: pancreatic intraepithelial neoplasia, intraductal papillary mucinous neoplasm, and mucinous cystic neoplasm. Each of these precursor lesions is associated with specific molecular alterations. OBJECTIVE: To understand the molecular characteristics of pancreatic ductal adenocarcinoma and its precursor lesions. DATA SOURCES: PubMed (US National Library of Medicine). CONCLUSIONS: In this review, we briefly summarize recent research findings on the genetics and epigenetics of pancreatic cancer. In addition, we characterize these molecular alterations in the context of the histologic subtypes of pancreatic cancer.
Authors: R E Wilentz; G H Su; J L Dai; A B Sparks; P Argani; T A Sohn; C J Yeo; S E Kern; R H Hruban Journal: Am J Pathol Date: 2000-01 Impact factor: 4.307
Authors: B C Blount; M M Mack; C M Wehr; J T MacGregor; R A Hiatt; G Wang; S N Wickramasinghe; R B Everson; B N Ames Journal: Proc Natl Acad Sci U S A Date: 1997-04-01 Impact factor: 11.205
Authors: M Schutte; R H Hruban; J Geradts; R Maynard; W Hilgers; S K Rabindran; C A Moskaluk; S A Hahn; I Schwarte-Waldhoff; W Schmiegel; S B Baylin; S E Kern; J G Herman Journal: Cancer Res Date: 1997-08-01 Impact factor: 12.701
Authors: Y Sakai; A A Kupelioglu; A Yanagisawa; K Yamaguchi; E Hidaka; S Matsuya; T Ohbuchi; Y Tada; H Saisho; Y Kato Journal: Hum Pathol Date: 2000-10 Impact factor: 3.466
Authors: Bodo Brueckner; Carlo Stresemann; Ruprecht Kuner; Cora Mund; Tanja Musch; Michael Meister; Holger Sültmann; Frank Lyko Journal: Cancer Res Date: 2007-02-15 Impact factor: 12.701
Authors: Norihiro Sato; Takashi Ueki; Noriyoshi Fukushima; Christine A Iacobuzio-Donahue; Charles J Yeo; John L Cameron; Ralph H Hruban; Michael Goggins Journal: Gastroenterology Date: 2002-07 Impact factor: 22.682
Authors: Christine A Iacobuzio-Donahue; Jason Song; Giovanni Parmiagiani; Charles J Yeo; Ralph H Hruban; Scott E Kern Journal: Clin Cancer Res Date: 2004-03-01 Impact factor: 12.531
Authors: J Wu; S Liu; J Yu; G Zhou; D Rao; C M Jay; P Kumar; R Sanchez; N Templeton; N Senzer; P Maples; J Nemunaitis; F C Brunicardi Journal: Cancer Gene Ther Date: 2014-01-24 Impact factor: 5.987