Literature DB >> 21630067

Acute myeloid leukemia (AML-M2) with translocation (8;21) (q22;q22) and abnormal eosinophilic precursors in the bone marrow--a case report.

Oneal Gupta1, Roopak Aggarwal, Rajni Prasad.   

Abstract

The translocation (8;21)(q22;q22) is frequently associated with M2 subtype of AML. The authors herein present a case of AML-M2 in a nine-year-old boy without hepatosplenomegaly, lymphadenopathy or any bleeding diathesis. Bone marrow examination revealed high number of eosinophilic precursors (60%) among the total nucleated bone marrow cells. Cytogenetic study with G- banding method showed 46, XY, t (8;21)(q22;q22). The morphological abnormalities in eosinophils observed in AML suggested that eosinophils may be a part of leukemic process.

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Year:  2011        PMID： 21630067     DOI： 10.1007/s12098-011-0481-2

Source DB:  PubMed          Journal:  Indian J Pediatr        ISSN： 0019-5456            Impact factor:   1.967


  9 in total

1.  Cryptic chromosomal anomaly in a patient with acute myeloid leukemia leading to AML1/ETO fusion with unfavorable prognostic factors.

Authors:  Yuko Ishii; Goro Sashida; Tomo-Iku Takaku; Masahiko Sumi; Akihiro Nakajima; Kazuma Ohyashiki
Journal:  Cancer Genet Cytogenet       Date:  2005-07-01

Review 2.  Molecular cytogenetic aspects of hematological malignancies: clinical implications.

Authors:  Zhong Chen; Avery A Sandberg
Journal:  Am J Med Genet       Date:  2002-10-30

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Journal:  Cancer Genet Cytogenet       Date:  1987-12

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Authors:  H Ema; K Kitano; T Suda; Y Sato; K Muroi; M Ohta; M Yoshida; S Sakamoto; M Eguchi; Y Miura
Journal:  Blood       Date:  1990-01-15       Impact factor: 22.113

5.  The Fourth International Workshop on Chromosomes in Leukemia: a prospective study of acute nonlymphocytic leukemia. Chicago, Illinois, U.S.A., September 2-7, 1982.

Authors: 
Journal:  Cancer Genet Cytogenet       Date:  1984-03

6.  8;21 translocation in acute granulocytic leukaemia: cytological, cytochemical and clinical features.

Authors:  D M Swirsky; Y S Li; J G Matthews; R J Flemans; J K Rees; F G Hayhoe
Journal:  Br J Haematol       Date:  1984-02       Impact factor: 6.998

7.  Childhood acute myeloid leukemia: an Indian perspective.

Authors:  Ketan Prasad Kulkarni; Ram Kumar Marwaha
Journal:  Pediatr Hematol Oncol       Date:  2011-01-08       Impact factor: 1.969

8.  Phenotypical characteristics of acute myelocytic leukemia associated with the t(8;21)(q22;q22) chromosomal abnormality: frequent expression of immature B-cell antigen CD19 together with stem cell antigen CD34.

Authors:  K Kita; K Nakase; H Miwa; M Masuya; K Nishii; N Morita; N Takakura; A Otsuji; S Shirakawa; T Ueda
Journal:  Blood       Date:  1992-07-15       Impact factor: 22.113

9.  Frequency of prolonged remission duration after high-dose cytarabine intensification in acute myeloid leukemia varies by cytogenetic subtype.

Authors:  C D Bloomfield; D Lawrence; J C Byrd; A Carroll; M J Pettenati; R Tantravahi; S R Patil; F R Davey; D T Berg; C A Schiffer; D C Arthur; R J Mayer
Journal:  Cancer Res       Date:  1998-09-15       Impact factor: 12.701
  9 in total

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