Literature DB >> 21625978

Human cytomegalovirus latency-associated protein LUNA is expressed during HCMV infections in vivo.

Mariana G Bego1, Lisa R Keyes, Jarek Maciejewski, Stephen C St Jeor.   

Abstract

Human cytomegalovirus (HCMV) latency is poorly understood. We previously described a novel HCMV latency-associated transcript, UL81-82ast, coding for a protein designated LUNA (latency unique natural antigen). The aim of this study was to confirm the presence of LUNA in HCMV-seropositive donors. Standard co-immunoprecipitation and ELISA assays were used to detect antibodies against the LUNA protein in the sera of HCMV-seropositive donors. Specific antibodies against LUNA were detected in all HCMV-seropositive donors but in none of the seronegative donors. These data confirm that LUNA is expressed during in vivo infections and is capable of eliciting an immune response.

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Year:  2011        PMID： 21625978     DOI： 10.1007/s00705-011-1027-7

Source DB:  PubMed          Journal:  Arch Virol        ISSN： 0304-8608            Impact factor:   2.574


  12 in total

1.  A myeloid progenitor cell line capable of supporting human cytomegalovirus latency and reactivation, resulting in infectious progeny.

Authors:  Christine M O'Connor; Eain A Murphy
Journal:  J Virol       Date:  2012-07-03       Impact factor: 5.103

Review 2.  Human cytomegalovirus persistence.

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Journal:  Cell Microbiol       Date:  2012-03-08       Impact factor: 3.715

3.  Tale of a tegument transactivator: the past, present and future of human CMV pp71.

Authors:  Rhiannon R Penkert; Robert F Kalejta
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4.  Host microRNA regulation of human cytomegalovirus immediate early protein translation promotes viral latency.

Authors:  Christine M O'Connor; Jiri Vanicek; Eain A Murphy
Journal:  J Virol       Date:  2014-03-05       Impact factor: 5.103

5.  The loss of binary: Pushing the herpesvirus latency paradigm.

Authors:  Donna Collins-McMillen; Felicia D Goodrum
Journal:  Curr Clin Microbiol Rep       Date:  2017-08-15

6.  Cis and trans acting factors involved in human cytomegalovirus experimental and natural latent infection of CD14 (+) monocytes and CD34 (+) cells.

Authors:  Cyprian C Rossetto; Margaret Tarrant-Elorza; Gregory S Pari
Journal:  PLoS Pathog       Date:  2013-05-23       Impact factor: 6.823

Review 7.  Functional annotation of human cytomegalovirus gene products: an update.

Authors:  Ellen Van Damme; Marnix Van Loock
Journal:  Front Microbiol       Date:  2014-05-19       Impact factor: 5.640

8.  Glucocorticosteroids trigger reactivation of human cytomegalovirus from latently infected myeloid cells and increase the risk for HCMV infection in D+R+ liver transplant patients.

Authors:  Ellen Van Damme; Sarah Sauviller; Betty Lau; Bart Kesteleyn; Paul Griffiths; Andrew Burroughs; Vincent Emery; John Sinclair; Marnix Van Loock
Journal:  J Gen Virol       Date:  2014-10-13       Impact factor: 3.891

9.  HCMV Displays a Unique Transcriptome of Immunomodulatory Genes in Primary Monocyte-Derived Cell Types.

Authors:  Ellen Van Damme; Kim Thys; Marianne Tuefferd; Carl Van Hove; Jeroen Aerssens; Marnix Van Loock
Journal:  PLoS One       Date:  2016-10-19       Impact factor: 3.240

10.  HCMV protein LUNA is required for viral reactivation from latently infected primary CD14⁺ cells.

Authors:  Lisa R Keyes; Danna Hargett; Melisa Soland; Mariana G Bego; Cyprian C Rossetto; Graca Almeida-Porada; Stephen St Jeor
Journal:  PLoS One       Date:  2012-12-26       Impact factor: 3.240
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