Literature DB >> 21625949

Acoschimperoside P, 2'-acetate: a Hedgehog signaling inhibitory constituent from Vallaris glabra.

Yusnita Rifai1, Midori A Arai, Takashi Koyano, Thaworn Kowithayakorn, Masami Ishibashi.   

Abstract

Complete (1)H and (13)C NMR assignments of acoschimperoside P, 2'-acetate (1) and a new cardiac glycoside (2), isolated from the leaves of Vallaris glabra, are described. Compound 1 was active in the assay for Hedgehog signaling inhibition. In further experiments, this compound showed a strong cytotoxicity against human pancreatic (PANC1) and human prostate (DU145) cancer cells. The expression of GLI-related proteins (PTCH and BCL-2) in a dose-dependent manner was also inhibited by 1.

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Year:  2011        PMID： 21625949     DOI： 10.1007/s11418-011-0530-1

Source DB:  PubMed          Journal:  J Nat Med        ISSN： 1340-3443            Impact factor:   2.343


  10 in total

1.  Terpenoids and a flavonoid glycoside from Acacia pennata leaves as hedgehog/GLI-mediated transcriptional inhibitors.

Authors:  Yusnita Rifai; Midori A Arai; Takashi Koyano; Thaworn Kowithayakorn; Masami Ishibashi
Journal:  J Nat Prod       Date:  2010-05-28       Impact factor: 4.050

Review 2.  Hedgehog signalling in cancer formation and maintenance.

Authors:  Marina Pasca di Magliano; Matthias Hebrok
Journal:  Nat Rev Cancer       Date:  2003-12       Impact factor: 60.716

3.  [THE GLYCOSIDES OF THE SEEDS OF VALLARIS SOLANACEA (ROTH) O.K. CLARIFICATION OF STRUCTURE. GLYCOSIDES AND AGLYCONES, 264].

Authors:  H KAUFMANN
Journal:  Helv Chim Acta       Date:  1965-01-02       Impact factor: 2.164

Review 4.  Targeting the Hedgehog pathway in cancer.

Authors:  Lee L Rubin; Frederic J de Sauvage
Journal:  Nat Rev Drug Discov       Date:  2006-12       Impact factor: 84.694

5.  New Hedgehog/GLI signaling inhibitors from Excoecaria agallocha.

Authors:  Yusnita Rifai; Midori A Arai; Samir K Sadhu; Firoj Ahmed; Masami Ishibashi
Journal:  Bioorg Med Chem Lett       Date:  2010-12-05       Impact factor: 2.823

6.  Naturally occurring small-molecule inhibitors of hedgehog/GLI-mediated transcription.

Authors:  Takahiro Hosoya; Midori A Arai; Takashi Koyano; Thaworn Kowithayakorn; Masami Ishibashi
Journal:  Chembiochem       Date:  2008-05-05       Impact factor: 3.164

7.  [6-desoxy-L-idose, 6-desoxy-L-sorbose, and 6-desoxy-L-psicose].

Authors:  H Kaufmann; T Reichstein
Journal:  Helv Chim Acta       Date:  1967-12-11       Impact factor: 2.164

8.  Hedgehog/GLI-mediated transcriptional inhibitors from Zizyphus cambodiana.

Authors:  Midori A Arai; Chikashi Tateno; Takahiro Hosoya; Takashi Koyano; Thaworn Kowithayakorn; Masami Ishibashi
Journal:  Bioorg Med Chem       Date:  2008-09-24       Impact factor: 3.641

9.  Identification and quantitation of the rice aroma compound, 2-acetyl-1-pyrroline, in bread flowers (Vallaris glabra Ktze).

Authors:  Sugunya Wongpornchai; Tinakorn Sriseadka; Suppachai Choonvisase
Journal:  J Agric Food Chem       Date:  2003-01-15       Impact factor: 5.279

10.  Laboratory determination of chemotherapeutic drug resistance in tumor cells from patients with leukemia, using a fluorometric microculture cytotoxicity assay (FMCA).

Authors:  R Larsson; J Kristensen; C Sandberg; P Nygren
Journal:  Int J Cancer       Date:  1992-01-21       Impact factor: 7.396
  10 in total
  4 in total

1.  Hedgehog/GLI-mediated transcriptional activity inhibitors from Crinum asiaticum.

Authors:  Midori A Arai; Ryuta Akamine; Samir K Sadhu; Firoj Ahmed; Masami Ishibashi
Journal:  J Nat Med       Date:  2015-05-31       Impact factor: 2.343

2.  Characterization and stability evaluation of nanoencapsulated epoxylignans.

Authors:  Yusnita Rifai; Radhia Riski; Gemini Alam; Magdalena Litaay; Latifah Rahman
Journal:  F1000Res       Date:  2018-03-01

3.  Three new cardiac glycosides obtained from the roots of Streblus asper Lour. and their cytotoxic and melanogenesis-inhibitory activities.

Authors:  Dan Miao; Tengqian Zhang; Jian Xu; Congyu Ma; Wenyuan Liu; Takashi Kikuchi; Toshihiro Akihisa; Masahiko Abe; Feng Feng; Jie Zhang
Journal:  RSC Adv       Date:  2018-05-29       Impact factor: 4.036

4.  Antiproliferative activity of Vallaris glabra Kuntze (Apocynaceae).

Authors:  Siu Kuin Wong; Yau Yan Lim; Sui Kiong Ling; Eric Wei Chiang Chan
Journal:  Pharmacogn Mag       Date:  2014-04       Impact factor: 1.085
  4 in total

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