OBJECTIVES: Nephrogenic systemic fibrosis is a novel clinical entity encountered in subjects undergoing contrast enhanced magnetic resonance imaging (MRI). The aim of the present study is to evaluate the impact of contrast enhanced MRI exposure on lymphocyte DNA damage and serum levels of visfatin. DESIGN AND METHODS: Twenty-eight subjects undergoing contrast enhanced hypophysial MRI with omniscan were included in the study. Blood samples were drawn before MRI, after non-contrast MRI and after contrast enhanced MRI from each subject. Lymphocyte DNA damage was analyzed by the alkaline comet assay, whereas serum visfatin level was assessed with enzyme immuno assay. RESULTS: Both lymphocyte DNA damage and serum visfatin levels were statistically significantly increased in samples withdrawn after contrast enhanced MRI compared to samples withdrawn after non-contrast enhanced MRI and baseline samples (ANOVA p<0.001, for both). CONCLUSIONS: Findings of the present study revealed that the contrast enhanced MRI is associated with increased lymphocyte DNA damage and increased serum visfatin level.
OBJECTIVES:Nephrogenic systemic fibrosis is a novel clinical entity encountered in subjects undergoing contrast enhanced magnetic resonance imaging (MRI). The aim of the present study is to evaluate the impact of contrast enhanced MRI exposure on lymphocyte DNA damage and serum levels of visfatin. DESIGN AND METHODS: Twenty-eight subjects undergoing contrast enhanced hypophysial MRI with omniscan were included in the study. Blood samples were drawn before MRI, after non-contrast MRI and after contrast enhanced MRI from each subject. Lymphocyte DNA damage was analyzed by the alkaline comet assay, whereas serum visfatin level was assessed with enzyme immuno assay. RESULTS: Both lymphocyte DNA damage and serum visfatin levels were statistically significantly increased in samples withdrawn after contrast enhanced MRI compared to samples withdrawn after non-contrast enhanced MRI and baseline samples (ANOVA p<0.001, for both). CONCLUSIONS: Findings of the present study revealed that the contrast enhanced MRI is associated with increased lymphocyte DNA damage and increased serum visfatin level.
Authors: William R Critchley; Anna Reid; Julie Morris; Josephine H Naish; John P Stone; Alexandra L Ball; Triin Major; David Clark; Nick Waldron; Christien Fortune; Jakub Lagan; Gavin A Lewis; Mark Ainslie; Erik B Schelbert; Daniel M Davis; Matthias Schmitt; James E Fildes; Christopher A Miller Journal: Eur Heart J Date: 2018-01-21 Impact factor: 29.983
Authors: Theresa Reiter; Oliver Ritter; Martin R Prince; Peter Nordbeck; Christoph Wanner; Eike Nagel; Wolfgang Rudolf Bauer Journal: J Cardiovasc Magn Reson Date: 2012-05-20 Impact factor: 5.364
Authors: Michael Fiechter; Julia Stehli; Tobias A Fuchs; Svetlana Dougoud; Oliver Gaemperli; Philipp A Kaufmann Journal: Eur Heart J Date: 2013-06-21 Impact factor: 29.983
Authors: Jennifer S McDonald; Robert J McDonald; Jacob B Ekins; Anthony S Tin; Sylvain Costes; Tamara M Hudson; Dana J Schroeder; Kevin Kallmes; Scott H Kaufmann; Philip M Young; Aiming Lu; Ramanathan Kadirvel; David F Kallmes Journal: PLoS One Date: 2018-01-08 Impact factor: 3.240