| Literature DB >> 21619045 |
Jean J K Bankeu1, Rustamova Khayala, Bruno N Lenta, Didérot T Noungoué, Silvère A Ngouela, Sufyan A Mustafa, Khalid Asaad, Mohammed I Choudhary, Sean T Prigge, Ralphreed Hasanov, Augustin E Nkengfack, Etienne Tsamo, Muhammad S Ali.
Abstract
Phytochemical investigation of the figs of Ficus mucuso led to the isolation of three new isoflavone dimer derivatives, mucusisoflavones A-C (1-3), together with 16 known compounds. Some of the isolates were tested in vitro for their inhibitory properties toward β-glucuronidase and Plasmodium falciparum enoyl-ACP reductase (PfENR) enzymes. Compound 1 (IC₅₀) 0.68 μM) showed inhibitory activity on β-glucuronidase enzyme, while 3 (IC₅₀) 7.69 μM) exhibited a weak inhibitory activity against P. falciparum enoyl-ACP reductase (PfENR).Entities:
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Year: 2011 PMID： 21619045 DOI： 10.1021/np100896w
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050