Literature DB >> 2161812

Modulation of c-myc expression by transforming growth factor beta 1 in human hepatoma cell lines.

N Ito1, S Kawata, S Tamura, K Takaishi, R Saitoh, S Tarui.   

Abstract

The effects of transforming growth factor beta 1 (TGF-beta 1) on cell proliferation of human hepatoma cell lines, PLC/PRF/5 and Mahlavu, were investigated under serum-free conditions. DNA synthesis was strongly inhibited in the PLC/PRF/5 cells by addition of TGF-beta 1 (0.5 to 4.0 ng/ml), but remained unchanged in the Mahlavu cells. Also the expression of c-myc mRNA was suppressed by the addition of TGF-beta 1 in the PLC/PRF/5 cells but not in the Mahlavu cells. These results indicate that TGF-beta 1 might regulate cell growth, in part, by modulating c-myc expression, although there is no direct proof that c-myc expression is really relevant to DNA synthesis mediated by TGF-beta 1.

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Year:  1990        PMID： 2161812      PMCID： PMC5918033          DOI： 10.1111/j.1349-7006.1990.tb02552.x

Source DB:  PubMed          Journal:  Jpn J Cancer Res        ISSN： 0910-5050


  28 in total

1.  Oncogene expression in human hepatoma cells PLC/PRF/5.

Authors:  Y Motoo; M Mahmoudi; K Osther; A P Bollon
Journal:  Biochem Biophys Res Commun       Date:  1986-02-26       Impact factor: 3.575

Review 2.  Peptide growth factors are multifunctional.

Authors:  M B Sporn; A B Roberts
Journal:  Nature       Date:  1988-03-17       Impact factor: 49.962

3.  Homogeneously staining chromosomal regions contain amplified copies of an abundantly expressed cellular oncogene (c-myc) in malignant neuroendocrine cells from a human colon carcinoma.

Authors:  K Alitalo; M Schwab; C C Lin; H E Varmus; J M Bishop
Journal:  Proc Natl Acad Sci U S A       Date:  1983-03       Impact factor: 11.205

4.  The expression of oncogenes in human developing liver and hepatomas.

Authors:  X K Zhang; D P Huang; D K Chiu; J F Chiu
Journal:  Biochem Biophys Res Commun       Date:  1987-02-13       Impact factor: 3.575

5.  Inhibition of DNA synthesis in rat hepatocytes by platelet-derived type beta transforming growth factor.

Authors:  B I Carr; I Hayashi; E L Branum; H L Moses
Journal:  Cancer Res       Date:  1986-05       Impact factor: 12.701

6.  Differential control by platelet factors of squamous differentiation in normal and malignant human bronchial epithelial cells.

Authors:  J F Lechner; I A McClendon; M A LaVeck; A M Shamsuddin; C C Harris
Journal:  Cancer Res       Date:  1983-12       Impact factor: 12.701

7.  Suppression of the EGF-dependent induction of c-myc proto-oncogene expression by transforming growth factor beta in a human breast carcinoma cell line.

Authors:  J A Fernandez-Pol; V D Talkad; D J Klos; P D Hamilton
Journal:  Biochem Biophys Res Commun       Date:  1987-05-14       Impact factor: 3.575

8.  Inhibition of proliferation of normal, preneoplastic, and neoplastic rat hepatocytes by transforming growth factor-beta.

Authors:  G K Wollenberg; E Semple; B A Quinn; M A Hayes
Journal:  Cancer Res       Date:  1987-12-15       Impact factor: 12.701

9.  Type beta transforming growth factor is the primary differentiation-inducing serum factor for normal human bronchial epithelial cells.

Authors:  T Masui; L M Wakefield; J F Lechner; M A LaVeck; M B Sporn; C C Harris
Journal:  Proc Natl Acad Sci U S A       Date:  1986-04       Impact factor: 11.205

Review 10.  Dysregulation of growth factor-receptor system in cellular transformation.

Authors:  M Hatakeyama; T Taniguchi
Journal:  Jpn J Cancer Res       Date:  1988-08
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  1 in total

1.  Elevated levels of plasma transforming growth factor-beta in patients with hepatocellular carcinoma.

Authors:  Y Shirai; S Kawata; N Ito; S Tamura; K Takaishi; S Kiso; H Tsushima; Y Matsuzawa
Journal:  Jpn J Cancer Res       Date:  1992-07
  1 in total

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