Literature DB >> 2161771

Detection of inflammatory lesions with radiolabelled immunoglobulins.

D Blok1, M von Ogtrop, J W Arndt, J A Camps, R I Feitsma, W Goedemans, E K Pauwels.   

Abstract

Previous reports on the use of radiolabelled immunoglobulins led us to undertake a pilot experiment in an animal model to investigate the potentials of Tc 99m-immunoglobulin scintigraphy in the detection of infectious foci. Mice infected in one leg with staphylococcus infection were injected with Tc 99m-immunoglobulin, Tc 99m-albumin or gallium citrate Ga 67. The results obtained by scintigraphy suggested a specific accumulation of radiolabelled immunoglobulin at the site of infection. Visualization of the infection and the image quality, especially the 6- and 24-h images, were clearly enhanced after the use of immunoglobulin preparations as compared with gallium.

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Year:  1990        PMID： 2161771     DOI： 10.1007/BF00842784

Source DB:  PubMed          Journal:  Eur J Nucl Med        ISSN： 0340-6997


  8 in total

1.  A new method for 99Tcm-labelling of proteins with an application to clot detection with an antifibrin monoclonal antibody.

Authors:  R I Feitsma; D Blok; M N Wasser; W Nieuwenhuizen; E K Pauwels
Journal:  Nucl Med Commun       Date:  1987-10       Impact factor: 1.690

2.  Inflammation: imaging with Tc-99m HMPAO-labeled leukocytes.

Authors:  M E Roddie; A M Peters; H J Danpure; S Osman; B L Henderson; J P Lavender; M J Carroll; R D Neirinckx; J D Kelly
Journal:  Radiology       Date:  1988-03       Impact factor: 11.105

3.  Comparison of 123I monoclonal granulocyte antibody and 99Tcm-HMPAO-labelled leucocytes in the detection of inflammation.

Authors:  M Vorne; K Karhunen; T Lantto; R Mokka; P Mäkelä; J Nikoskelainen; A Rajamäki
Journal:  Nucl Med Commun       Date:  1988-09       Impact factor: 1.690

4.  Specific and nonspecific imaging of localized Fisher immunotype 1 Pseudomonas aeruginosa infection with radiolabeled monoclonal antibody.

Authors:  R H Rubin; L S Young; W P Hansen; M Nedelman; R Wilkinson; M J Nelles; R Callahan; B A Khaw; H W Strauss
Journal:  J Nucl Med       Date:  1988-05       Impact factor: 10.057

5.  Imaging of inflammatory and infectious lesions after injection of radioiodinated monoclonal anti-granulocytes antibodies.

Authors:  J T Locher; K Seybold; R Y Andres; P A Schubiger; J P Mach; F Buchegger
Journal:  Nucl Med Commun       Date:  1986-09       Impact factor: 1.690

6.  Detection of acute inflammation with 111In-labeled nonspecific polyclonal IgG.

Authors:  A J Fischman; R H Rubin; B A Khaw; R J Callahan; R Wilkinson; F Keech; M Nedelman; S Dragotakes; P B Kramer; G M LaMuraglia
Journal:  Semin Nucl Med       Date:  1988-10       Impact factor: 4.446

7.  Value of indium-111 granulocyte scintigraphy in the assessment of Crohn's disease of the small intestine: prospective investigation.

Authors:  G E Crama-Bohbouth; J W Arndt; A S Peña; H W Verspaget; R T Tjon A Tham; I T Weterman; E K Pauwels; C B Lamers
Journal:  Digestion       Date:  1988       Impact factor: 3.216

8.  Clinical experience with 99mTc-hexamethylpropylene-amineoxime for labelling leucocytes and imaging inflammation.

Authors:  A M Peters; H J Danpure; S Osman; R J Hawker; B L Henderson; H J Hodgson; J D Kelly; R D Neirinckx; J P Lavender
Journal:  Lancet       Date:  1986-10-25       Impact factor: 79.321
  8 in total
  6 in total

1.  Accumulation of immunoglobulin G at focal sites of inflammation.

Authors:  M Juweid; H W Strauss; H Yaoita; R H Rubin; A J Fischman
Journal:  Eur J Nucl Med       Date:  1992

2.  Binding of 99mTc-labelled polyclonal human immunoglobulin to bacteria as a mechanism for scintigraphic detection of infection.

Authors:  W Calame; H I Feitsma; G J Ensing; J W Arndt; R van Furth; E K Pauwels
Journal:  Eur J Nucl Med       Date:  1991

Review 3.  Radiopharmaceuticals: state of the art.

Authors:  A M Verbruggen
Journal:  Eur J Nucl Med       Date:  1990

4.  99mTc-human immunoglobulin (HIG)--first results of a new agent for the localization of infection and inflammation.

Authors:  J R Buscombe; D Lui; G Ensing; R de Jong; P J Ell
Journal:  Eur J Nucl Med       Date:  1990

5.  Radionuclide imaging with human polyclonal immunoglobulin (Tc-HIG) and bone scan in patients with rheumatoid arthritis and serum-negative polyarthritis.

Authors:  G Gerasimou; E Moralidis; E Papanastasiou; G Liaros; T Aggelopoulou; E Triantafyllidou; N Lytras; L Settas; A Gotzamani-Psarrakou
Journal:  Hippokratia       Date:  2011-01       Impact factor: 0.471

6.  Optimized localization of bacterial infections with technetium-99m labelled human immunoglobulin after protein charge selection.

Authors:  M Welling; H I Feitsma; W Calame; G J Ensing; W Goedemans; E K Pauwels
Journal:  Eur J Nucl Med       Date:  1994-10
  6 in total

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